BRPI0810384B8 - terapia enzimática anticâncer - Google Patents

terapia enzimática anticâncer

Info

Publication number
BRPI0810384B8
BRPI0810384B8 BRPI0810384A BRPI0810384A BRPI0810384B8 BR PI0810384 B8 BRPI0810384 B8 BR PI0810384B8 BR PI0810384 A BRPI0810384 A BR PI0810384A BR PI0810384 A BRPI0810384 A BR PI0810384A BR PI0810384 B8 BRPI0810384 B8 BR PI0810384B8
Authority
BR
Brazil
Prior art keywords
enzyme therapy
anticancer
anticancer enzyme
patient
therapy
Prior art date
Application number
BRPI0810384A
Other languages
English (en)
Inventor
R Filpula David
Sapra Puja
Original Assignee
Defiante Farm S A
Enzon Pharmaceuticals Inc
Leadiant Biosciences Ltd
Sigma Tau Pharma Ltd
Sigma Tau Rare Disease Ltd
Sigma Tau Rare Diseases S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Defiante Farm S A, Enzon Pharmaceuticals Inc, Leadiant Biosciences Ltd, Sigma Tau Pharma Ltd, Sigma Tau Rare Disease Ltd, Sigma Tau Rare Diseases S A filed Critical Defiante Farm S A
Publication of BRPI0810384A2 publication Critical patent/BRPI0810384A2/pt
Publication of BRPI0810384B1 publication Critical patent/BRPI0810384B1/pt
Publication of BRPI0810384B8 publication Critical patent/BRPI0810384B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
    • C12Y305/04004—Adenosine deaminase (3.5.4.4)

Abstract

terapia enzimática anticâncer o que é proporcionado é um método para tratar um paciente que tem um tumor compreendendo administrar uma quantidade eficaz de adenosina deaminase, preferencialmente conjugada com óxido de polialquileno, a um paciente que necessita do mesmo.
BRPI0810384A 2007-04-20 2008-04-18 terapia enzimática anticâncer BRPI0810384B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91303907P 2007-04-20 2007-04-20
US60/913,039 2007-04-20
PCT/US2008/060733 WO2008131163A1 (en) 2007-04-20 2008-04-18 Enzymatic anticancer therapy

Publications (3)

Publication Number Publication Date
BRPI0810384A2 BRPI0810384A2 (pt) 2014-11-04
BRPI0810384B1 BRPI0810384B1 (pt) 2021-02-02
BRPI0810384B8 true BRPI0810384B8 (pt) 2021-05-25

Family

ID=39875909

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0810384A BRPI0810384B8 (pt) 2007-04-20 2008-04-18 terapia enzimática anticâncer

Country Status (19)

Country Link
US (1) US8741283B2 (pt)
EP (1) EP2147122B1 (pt)
JP (1) JP5595904B2 (pt)
KR (1) KR101540296B1 (pt)
CN (1) CN101680039B (pt)
BR (1) BRPI0810384B8 (pt)
CA (1) CA2684749C (pt)
CY (1) CY1117000T1 (pt)
DK (1) DK2147122T3 (pt)
ES (1) ES2507508T3 (pt)
HR (1) HRP20140947T1 (pt)
IL (1) IL201593A (pt)
MX (1) MX2009011320A (pt)
NZ (1) NZ580980A (pt)
PL (1) PL2147122T3 (pt)
PT (1) PT2147122E (pt)
SI (1) SI2147122T1 (pt)
TW (1) TWI486169B (pt)
WO (1) WO2008131163A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2534304T3 (es) 2004-11-12 2015-04-21 Asuragen, Inc. Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN
PL2147116T3 (pl) 2007-04-20 2016-08-31 Leadiant Biosciences Ltd Stabilna rekombinowana dezaminaza adenozynowa
SG192252A1 (en) * 2011-02-03 2013-09-30 Mirna Therapeutics Inc Synthetic mimics of mir-34
JP6625627B2 (ja) 2014-10-14 2019-12-25 ハロザイム インコーポレイテッド アデノシンデアミナーゼ−２（ａｄａ２）、その変異体の組成物およびそれを使用する方法
WO2016191283A2 (en) * 2015-05-22 2016-12-01 University Of Houston System Enzymatic immunomodulation of solid tumors and user thereof
EP3426299A4 (en) * 2016-03-11 2019-10-16 University of Louisville Research Foundation, Inc. METHOD AND COMPOSITIONS FOR TREATMENT OF TUMORS
KR20190141695A (ko) 2017-04-13 2019-12-24 센티 바이오사이언시스, 인코포레이티드 병용 암 면역요법
AU2019359890A1 (en) 2018-10-17 2021-06-03 Senti Biosciences, Inc. Combinatorial cancer immunotherapy
US11419898B2 (en) 2018-10-17 2022-08-23 Senti Biosciences, Inc. Combinatorial cancer immunotherapy
WO2023086931A2 (en) * 2021-11-12 2023-05-19 Georgia Tech Research Corporation Adenosine deaminase 1 compositions and methods for using same

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5346823A (en) * 1984-05-29 1994-09-13 Genencor, Inc. Subtilisin modifications to enhance oxidative stability
US5122614A (en) * 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
US5324844A (en) * 1989-04-19 1994-06-28 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
US5349001A (en) * 1993-01-19 1994-09-20 Enzon, Inc. Cyclic imide thione activated polyalkylene oxides
US5643575A (en) * 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
US5605976A (en) * 1995-05-15 1997-02-25 Enzon, Inc. Method of preparing polyalkylene oxide carboxylic acids
US5919455A (en) * 1993-10-27 1999-07-06 Enzon, Inc. Non-antigenic branched polymer conjugates
US5730990A (en) * 1994-06-24 1998-03-24 Enzon, Inc. Non-antigenic amine derived polymers and polymer conjugates
US5756593A (en) * 1995-05-15 1998-05-26 Enzon, Inc. Method of preparing polyalkyene oxide carboxylic acids
CA2312975C (en) * 1997-12-17 2012-08-21 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
US6180095B1 (en) * 1997-12-17 2001-01-30 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
US6624142B2 (en) * 1997-12-30 2003-09-23 Enzon, Inc. Trimethyl lock based tetrapartate prodrugs
US5965119A (en) * 1997-12-30 1999-10-12 Enzon, Inc. Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents
US6251382B1 (en) * 1998-04-17 2001-06-26 Enzon, Inc. Biodegradable high molecular weight polymeric linkers and their conjugates
US6824766B2 (en) * 1998-04-17 2004-11-30 Enzon, Inc. Biodegradable high molecular weight polymeric linkers and their conjugates
US6153655A (en) * 1998-04-17 2000-11-28 Enzon, Inc. Terminally-branched polymeric linkers and polymeric conjugates containing the same
US6333396B1 (en) * 1998-10-20 2001-12-25 Enzon, Inc. Method for targeted delivery of nucleic acids
US20020088017A1 (en) * 1999-04-28 2002-07-04 Board Of Regents, The University Of Texas System Adenosine deaminase deficient transgenic mice and methods for the use thereof
US6579857B1 (en) * 1999-06-11 2003-06-17 Evanston Northwestern Healthcare Research Institute Combination cancer therapy comprising adenosine and deaminase enzyme inhibitors
AU7868400A (en) 1999-10-08 2001-04-23 Alza Corporation Neutral-cationic lipid for nucleic acid and drug delivery
AU2001297575A1 (en) 2000-11-08 2002-10-08 Millennium Pharmaceuticals, Inc. 38650, 28472, 5495, 65507, 81588 and 14354 methods and compositions of human proteins and uses thereof
AU2002365360A1 (en) * 2001-11-28 2003-06-10 Biopolymed Inc. Biologically active non-antigenic copolymer and conjugates thereof and methods for producing the same
WO2003050241A2 (en) 2001-12-12 2003-06-19 The Government Of The United States Of America As Represented By The Secretary, Department Of Healthand Human Services Methods for using extracellular adenosine inhibitors and adenosine receptor inhibitors to enhance immune response and inflammation
US7122189B2 (en) * 2002-08-13 2006-10-17 Enzon, Inc. Releasable polymeric conjugates based on aliphatic biodegradable linkers
US7413738B2 (en) * 2002-08-13 2008-08-19 Enzon Pharmaceuticals, Inc. Releasable polymeric conjugates based on biodegradable linkers
US7087229B2 (en) * 2003-05-30 2006-08-08 Enzon Pharmaceuticals, Inc. Releasable polymeric conjugates based on aliphatic biodegradable linkers
US20040175804A1 (en) * 2003-03-04 2004-09-09 Skonezny Paul M. Process for preparing dideoxyinosine using adenosine deaminase enzyme
US7301003B2 (en) * 2005-08-26 2007-11-27 Enzon Pharmaceuticals, Inc. Method of preparing polymers having terminal amine groups
US7601798B2 (en) * 2005-10-04 2009-10-13 Enzon Pharmaceuticals, Inc. Methods of preparing polymers having terminal amine groups using protected amine salts
US7989554B2 (en) * 2006-01-10 2011-08-02 Enzon Pharmaceuticals, Inc. Reacting polyalkylene oxide with base, tertiary alkyl haloacetate, then acid to prepare polyalkylene oxide carboxylic acid
EP2038424A2 (en) 2006-06-21 2009-03-25 Enzon Pharmaceuticals, Inc. Stabilized proteins
CN101534861B (zh) 2006-09-15 2013-10-02 安佐制药股份有限公司 具有基于位阻酯的生物可降解连接基的聚环氧烷
US20080159964A1 (en) * 2006-12-29 2008-07-03 Enzon Pharmaceuticals, Inc. Use of adenosine deaminase for treating pulmonary disease
PL2147116T3 (pl) 2007-04-20 2016-08-31 Leadiant Biosciences Ltd Stabilna rekombinowana dezaminaza adenozynowa

Also Published As

Publication number Publication date
PL2147122T3 (pl) 2015-05-29
US20090047270A1 (en) 2009-02-19
TWI486169B (zh) 2015-06-01
CN101680039A (zh) 2010-03-24
DK2147122T3 (da) 2014-10-13
NZ580980A (en) 2012-04-27
RU2009142817A (ru) 2011-05-27
US8741283B2 (en) 2014-06-03
TW200902051A (en) 2009-01-16
BRPI0810384B1 (pt) 2021-02-02
EP2147122A1 (en) 2010-01-27
EP2147122A4 (en) 2010-11-17
CY1117000T1 (el) 2017-04-05
AU2008242791A1 (en) 2008-10-30
MX2009011320A (es) 2009-12-15
IL201593A (en) 2017-07-31
KR101540296B1 (ko) 2015-07-31
KR20090130108A (ko) 2009-12-17
WO2008131163A8 (en) 2010-01-28
PT2147122E (pt) 2014-10-15
IL201593A0 (en) 2010-05-31
CA2684749A1 (en) 2008-10-30
JP5595904B2 (ja) 2014-09-24
CA2684749C (en) 2016-06-21
WO2008131163A1 (en) 2008-10-30
HRP20140947T1 (hr) 2015-02-13
ES2507508T3 (es) 2014-10-15
JP2010524968A (ja) 2010-07-22
EP2147122B1 (en) 2014-07-16
BRPI0810384A2 (pt) 2014-11-04
CN101680039B (zh) 2016-08-24
SI2147122T1 (sl) 2015-01-30

Similar Documents

Publication Publication Date Title
BRPI0810384B8 (pt) terapia enzimática anticâncer
PH12017501500A1 (en) Methods for treating non- small cell lung cancer using tor kinase inhibitor combination therapy
CY1118216T1 (el) Μεθοδοι αγωγης καρκινου
BR112015005227A2 (pt) inibidores de glicosilceramida sintase
EP4140487A8 (en) Combination therapy for treating cancer
NZ593343A (en) Combination cancer treatment conprising Abraxane and an inflamatory inhibitor
CO6670568A2 (es) Métodos de terapia combinada para tratar enfermedades profilerativas
BR112015012295A2 (pt) métodos para tratar um paciente, e, kit para identificar um paciente com câncer
BR112012024590A2 (pt) métodos de reforço da liberação de fármaco e da eficácia de agentes terapêuticos
IN2012DN02018A (pt)
ME01133B (me) Kombinovana terapija sa peptidnim epoksiketonima
BR112013004768A2 (pt) dispositivos e métodos para dilatar uma abertura de seio parasanal e para o tratamento de sinusite
MX2016007351A (es) Terapia de combinacion para tratar cancer.
ES2530462T3 (es) Combinación terapia antitumoral
BRPI0516177B8 (pt) oligorribonucleotídeos, uso dos mesmos, uso de um composto sirna eficaz para inibir 0 p53 humano e composição farmacêutica que os contém, bem como método para diminuição da expressão do gene p53
CO6531463A2 (es) Combinaciones de un inhibidor de pi3k y un inhibidor de mek
NI201200090A (es) Composiciones para tratar náusea y vómito centralmente mediados
MX2011007589A (es) Tratamiento de un cancer usando una combinacion de bendamustine y un anticuerpo anti-cd20.
MX366570B (es) Formulaciones de 5-fluorocitosina y usos de las mismas.
BR112013001838A2 (pt) formulações contendo extratos de echinacea angustifólia e zingiber officinale que são úteis na redução de inflamação e dor periférica
MX2011011596A (es) Perifosina y capecitabina como un tratamiento combinado para cancer.
BRPI0509876A (pt) métodos para controlar a angiogênese e a proliferação de células
MX2013006319A (es) Composiciones y metodos para tratar el cancer usando un inhibidor de pi3k y un inhibidor de mek.
UY32546A (es) Composiciones y metodos para tratar cancer
WO2007130501A3 (en) Combination therapy for treatment of cancer

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B25A Requested transfer of rights approved

Owner name: DEFIANTE FARMACEUTICA, S.A. (PT)

B25A Requested transfer of rights approved

Owner name: SIGMA-TAU RARE DISEASES, S.A. (PT)

B25A Requested transfer of rights approved

Owner name: SIGMA-TAU PHARMA LIMITED (GB)

B25A Requested transfer of rights approved

Owner name: SIGMA-TAU RARE DISEASE LTD. (GB)

B25D Requested change of name of applicant approved

Owner name: LEADIANT BIOSCIENCES LIMITED (GB)

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B65X Notification of requirement for priority examination of patent application
B65Y Grant of priority examination of the patent application (request complies with dec. 132/06 of 20061117)
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 02/02/2021, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 18/04/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B25A Requested transfer of rights approved

Owner name: UNIKERIS LIMITED (GB)