PL2147116T3 - Stabilna rekombinowana dezaminaza adenozynowa - Google Patents
Stabilna rekombinowana dezaminaza adenozynowaInfo
- Publication number
- PL2147116T3 PL2147116T3 PL08746255T PL08746255T PL2147116T3 PL 2147116 T3 PL2147116 T3 PL 2147116T3 PL 08746255 T PL08746255 T PL 08746255T PL 08746255 T PL08746255 T PL 08746255T PL 2147116 T3 PL2147116 T3 PL 2147116T3
- Authority
- PL
- Poland
- Prior art keywords
- adenosine deaminase
- stable recombinant
- recombinant adenosine
- stable
- deaminase
- Prior art date
Links
- 101710169336 5'-deoxyadenosine deaminase Proteins 0.000 title 1
- 102000055025 Adenosine deaminases Human genes 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
- C12Y305/04014—Deoxycytidine deaminase (3.5.4.14)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91300907P | 2007-04-20 | 2007-04-20 | |
| EP08746255.2A EP2147116B1 (en) | 2007-04-20 | 2008-04-18 | Stable recombinant adenosine deaminase |
| PCT/US2008/060805 WO2008131208A1 (en) | 2007-04-20 | 2008-04-18 | Stable recombinant adenosine deaminase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2147116T3 true PL2147116T3 (pl) | 2016-08-31 |
Family
ID=39875917
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL08746255T PL2147116T3 (pl) | 2007-04-20 | 2008-04-18 | Stabilna rekombinowana dezaminaza adenozynowa |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8071741B2 (pl) |
| EP (1) | EP2147116B1 (pl) |
| JP (1) | JP5511653B2 (pl) |
| KR (1) | KR101499095B1 (pl) |
| CN (1) | CN101688244B (pl) |
| AU (1) | AU2008242748B2 (pl) |
| BR (1) | BRPI0810383B1 (pl) |
| CA (1) | CA2684750C (pl) |
| DK (1) | DK2147116T3 (pl) |
| ES (1) | ES2569940T3 (pl) |
| HR (1) | HRP20160482T1 (pl) |
| HU (1) | HUE027603T2 (pl) |
| IL (1) | IL201592A (pl) |
| MX (1) | MX2009011319A (pl) |
| NZ (1) | NZ580981A (pl) |
| PL (1) | PL2147116T3 (pl) |
| SI (1) | SI2147116T1 (pl) |
| TW (1) | TWI412591B (pl) |
| WO (1) | WO2008131208A1 (pl) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI486169B (zh) | 2007-04-20 | 2015-06-01 | Sigma Tau Rare Diseases S A | 酵素性抗癌療法 |
| JP5907885B2 (ja) * | 2009-11-24 | 2016-04-26 | ダウ アグロサイエンシィズ エルエルシー | Ａａｄ−１２ダイズイベント４１６の検出 |
| RU2573933C1 (ru) * | 2014-08-21 | 2016-01-27 | Дафот Энтерпрайсис Лимитед | Пептид для лечения сахарного диабета 2-го типа и его осложнений |
| KR102122463B1 (ko) | 2014-10-14 | 2020-06-15 | 할로자임, 아이엔씨 | 아데노신 디아미네이즈-2(ada2)의 조성물, 이의 변이체 및 이를 사용하는 방법 |
| CN104531793B (zh) * | 2014-12-20 | 2018-04-27 | 郁庆明 | 全细胞生物转化制备l-2-氨基丁酸的方法 |
| AU2018251898A1 (en) | 2017-04-13 | 2019-10-31 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| JP7338873B2 (ja) * | 2017-07-19 | 2023-09-05 | ユニケリス・リミテッド | 強皮症関連血管障害を治療または改善するための組成物および方法 |
| JP7360951B2 (ja) * | 2018-02-09 | 2023-10-13 | 天野エンザイム株式会社 | 夾雑活性が低減したヌクレオシダーゼ剤 |
| US11419898B2 (en) | 2018-10-17 | 2022-08-23 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| AU2019359890B2 (en) | 2018-10-17 | 2024-10-24 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| EP4430195A4 (en) * | 2021-11-12 | 2025-09-24 | Georgia Tech Res Inst | ADENOSINE DEAMINASE 1 COMPOSITIONS AND METHODS OF USE THEREOF |
| CN116814595B (zh) * | 2023-08-30 | 2023-11-28 | 江苏申基生物科技有限公司 | 一种腺苷脱氨酶突变体及其固定化 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1181804A (en) | 1913-12-27 | 1916-05-02 | Frank Simpson | Removable bottle-valve. |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| ZA811368B (en) | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
| US5346823A (en) | 1984-05-29 | 1994-09-13 | Genencor, Inc. | Subtilisin modifications to enhance oxidative stability |
| US5324844A (en) | 1989-04-19 | 1994-06-28 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| US5122614A (en) | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| US5349001A (en) | 1993-01-19 | 1994-09-20 | Enzon, Inc. | Cyclic imide thione activated polyalkylene oxides |
| US5321095A (en) | 1993-02-02 | 1994-06-14 | Enzon, Inc. | Azlactone activated polyalkylene oxides |
| CN1104499C (zh) * | 1993-02-11 | 2003-04-02 | 吉恩康国际有限公司 | 氧化作用稳定的α－淀粉酶 |
| US5919455A (en) | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5605976A (en) | 1995-05-15 | 1997-02-25 | Enzon, Inc. | Method of preparing polyalkylene oxide carboxylic acids |
| US5650234A (en) | 1994-09-09 | 1997-07-22 | Surface Engineering Technologies, Division Of Innerdyne, Inc. | Electrophilic polyethylene oxides for the modification of polysaccharides, polypeptides (proteins) and surfaces |
| US5756593A (en) | 1995-05-15 | 1998-05-26 | Enzon, Inc. | Method of preparing polyalkyene oxide carboxylic acids |
| US5728560A (en) * | 1996-06-14 | 1998-03-17 | Enzon, Inc. | Method of treating CD4+ T cell lymphopenia in immuno-compromised patients |
| EP1037649B1 (en) | 1997-12-17 | 2009-09-30 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
| US6180095B1 (en) | 1997-12-17 | 2001-01-30 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
| GB2381622B (en) | 1997-12-17 | 2003-06-25 | Fujitsu Ltd | Synchronous dynamic random access memory apparatus |
| US5965119A (en) | 1997-12-30 | 1999-10-12 | Enzon, Inc. | Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents |
| US6624142B2 (en) | 1997-12-30 | 2003-09-23 | Enzon, Inc. | Trimethyl lock based tetrapartate prodrugs |
| US6824766B2 (en) | 1998-04-17 | 2004-11-30 | Enzon, Inc. | Biodegradable high molecular weight polymeric linkers and their conjugates |
| US6153655A (en) | 1998-04-17 | 2000-11-28 | Enzon, Inc. | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
| US6251382B1 (en) | 1998-04-17 | 2001-06-26 | Enzon, Inc. | Biodegradable high molecular weight polymeric linkers and their conjugates |
| US6207876B1 (en) * | 1998-04-28 | 2001-03-27 | Board Of Regents, The University Of Texas System | Adenosine deaminase deficient transgenic mice and methods for the use thereof |
| US6703381B1 (en) * | 1998-08-14 | 2004-03-09 | Nobex Corporation | Methods for delivery therapeutic compounds across the blood-brain barrier |
| US6366860B1 (en) | 2000-01-31 | 2002-04-02 | Biocatalytics, Inc. | Synthetic genes for enhanced expression |
| US7053150B2 (en) * | 2000-12-18 | 2006-05-30 | Nektar Therapeutics Al, Corporation | Segmented polymers and their conjugates |
| WO2003050241A2 (en) * | 2001-12-12 | 2003-06-19 | The Government Of The United States Of America As Represented By The Secretary, Department Of Healthand Human Services | Methods for using extracellular adenosine inhibitors and adenosine receptor inhibitors to enhance immune response and inflammation |
| JP2005528372A (ja) * | 2002-03-26 | 2005-09-22 | バイオシネクサス インコーポレイテッド | 抗菌ポリマー複合体 |
| US7087229B2 (en) | 2003-05-30 | 2006-08-08 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| US7122189B2 (en) | 2002-08-13 | 2006-10-17 | Enzon, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| US7413738B2 (en) | 2002-08-13 | 2008-08-19 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on biodegradable linkers |
| US20040136952A1 (en) | 2002-12-26 | 2004-07-15 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity |
| KR100512483B1 (ko) | 2003-05-07 | 2005-09-05 | 선바이오(주) | 신규한 폴리에틸렌글리콜-말레이미드 유도체의 합성방법 |
| US7301003B2 (en) | 2005-08-26 | 2007-11-27 | Enzon Pharmaceuticals, Inc. | Method of preparing polymers having terminal amine groups |
| US7601798B2 (en) | 2005-10-04 | 2009-10-13 | Enzon Pharmaceuticals, Inc. | Methods of preparing polymers having terminal amine groups using protected amine salts |
| US7989554B2 (en) | 2006-01-10 | 2011-08-02 | Enzon Pharmaceuticals, Inc. | Reacting polyalkylene oxide with base, tertiary alkyl haloacetate, then acid to prepare polyalkylene oxide carboxylic acid |
| JP2010500963A (ja) * | 2006-06-21 | 2010-01-14 | エンゾン ファーマスーティカルズ インコーポレイテッド | 安定化タンパク質 |
| EP2063912A4 (en) | 2006-09-15 | 2010-07-28 | Enzon Pharmaceuticals Inc | POLYALKYLENE OXIDES HAVING BIODEGRADABLE BOND SEGMENTS BASED ON COARSE ESTER |
| WO2008034124A2 (en) | 2006-09-15 | 2008-03-20 | Enzon Pharmaceuticals, Inc. | Targeted polymeric prodrugs containing multifunctional linkers |
| CA2671209A1 (en) * | 2006-12-29 | 2008-07-10 | Enzon Pharmaceuticals, Inc. | Use of adenosine deaminase for treating pulmonary disease |
| TWI486169B (zh) | 2007-04-20 | 2015-06-01 | Sigma Tau Rare Diseases S A | 酵素性抗癌療法 |
-
2008
- 2008-04-18 PL PL08746255T patent/PL2147116T3/pl unknown
- 2008-04-18 CA CA2684750A patent/CA2684750C/en not_active Expired - Fee Related
- 2008-04-18 SI SI200831605A patent/SI2147116T1/sl unknown
- 2008-04-18 EP EP08746255.2A patent/EP2147116B1/en active Active
- 2008-04-18 NZ NZ580981A patent/NZ580981A/en unknown
- 2008-04-18 MX MX2009011319A patent/MX2009011319A/es active IP Right Grant
- 2008-04-18 HU HUE08746255A patent/HUE027603T2/en unknown
- 2008-04-18 CN CN2008800211240A patent/CN101688244B/zh active Active
- 2008-04-18 TW TW097114406A patent/TWI412591B/zh active
- 2008-04-18 ES ES08746255.2T patent/ES2569940T3/es active Active
- 2008-04-18 BR BRPI0810383-6A patent/BRPI0810383B1/pt active IP Right Grant
- 2008-04-18 WO PCT/US2008/060805 patent/WO2008131208A1/en not_active Ceased
- 2008-04-18 US US12/105,913 patent/US8071741B2/en active Active
- 2008-04-18 AU AU2008242748A patent/AU2008242748B2/en active Active
- 2008-04-18 JP JP2010504270A patent/JP5511653B2/ja active Active
- 2008-04-18 DK DK08746255.2T patent/DK2147116T3/en active
- 2008-04-18 KR KR1020097023241A patent/KR101499095B1/ko active Active
- 2008-04-18 HR HRP20160482TT patent/HRP20160482T1/hr unknown
-
2009
- 2009-10-18 IL IL201592A patent/IL201592A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0810383B1 (pt) | 2022-12-20 |
| KR20100016302A (ko) | 2010-02-12 |
| RU2009142844A (ru) | 2011-05-27 |
| EP2147116A1 (en) | 2010-01-27 |
| AU2008242748B2 (en) | 2013-12-05 |
| US20090047271A1 (en) | 2009-02-19 |
| JP5511653B2 (ja) | 2014-06-04 |
| EP2147116A4 (en) | 2010-07-28 |
| IL201592A0 (en) | 2010-05-31 |
| IL201592A (en) | 2016-05-31 |
| WO2008131208A1 (en) | 2008-10-30 |
| ES2569940T3 (es) | 2016-05-13 |
| HK1142639A1 (en) | 2010-12-10 |
| DK2147116T3 (en) | 2016-05-30 |
| CN101688244A (zh) | 2010-03-31 |
| SI2147116T1 (sl) | 2016-06-30 |
| MX2009011319A (es) | 2009-12-11 |
| KR101499095B1 (ko) | 2015-03-05 |
| CA2684750A1 (en) | 2008-10-30 |
| NZ580981A (en) | 2012-02-24 |
| JP2010524472A (ja) | 2010-07-22 |
| EP2147116B1 (en) | 2016-03-02 |
| CA2684750C (en) | 2014-08-05 |
| AU2008242748A1 (en) | 2008-10-30 |
| TW200902719A (en) | 2009-01-16 |
| TWI412591B (zh) | 2013-10-21 |
| BRPI0810383A2 (pt) | 2019-08-27 |
| HUE027603T2 (en) | 2016-10-28 |
| US8071741B2 (en) | 2011-12-06 |
| HRP20160482T1 (hr) | 2016-06-03 |
| CN101688244B (zh) | 2013-05-08 |
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