BR112012020311A2 - "compostos, medicamento, método para inibir um ciclo de divisão celular, método para a profilaxia ou tratamento de câncer, e, uso do composto." - Google Patents
"compostos, medicamento, método para inibir um ciclo de divisão celular, método para a profilaxia ou tratamento de câncer, e, uso do composto."Info
- Publication number
- BR112012020311A2 BR112012020311A2 BR112012020311A BR112012020311A BR112012020311A2 BR 112012020311 A2 BR112012020311 A2 BR 112012020311A2 BR 112012020311 A BR112012020311 A BR 112012020311A BR 112012020311 A BR112012020311 A BR 112012020311A BR 112012020311 A2 BR112012020311 A2 BR 112012020311A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- cancer
- treatment
- prophylaxis
- inhibiting
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
Abstract
compostos, medicamento, método para inibir um ciclo de divisão celular, método para a profilaxia ou tratamento de câncer, e, uso do composto. é divulgado um composto útil como um agente profilático ou terapêutico para o câncer. é especificamente divulgado um composto representado pela fórmula (i). [em que cada símbolo é como definido na descrição] ou um sal deste, ou um pró-medicamento do composto ou sal deste, que é útil para a prevenção ou tratamento de câncer.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010031899 | 2010-02-17 | ||
JP2010-031899 | 2010-02-17 | ||
JP2010-131950 | 2010-06-09 | ||
JP2010131950 | 2010-06-09 | ||
PCT/JP2011/053303 WO2011102399A1 (ja) | 2010-02-17 | 2011-02-16 | 複素環化合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112012020311A2 true BR112012020311A2 (pt) | 2017-03-01 |
BR112012020311B1 BR112012020311B1 (pt) | 2019-01-29 |
Family
ID=44482985
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012020311-8A BR112012020311B1 (pt) | 2010-02-17 | 2011-02-16 | composto heterocíclico fundido tendo uma atividade inibidora de ciclo 7 de divisão celular forte (cdc7), e, medicamento compreendendo o mesmo |
Country Status (35)
Country | Link |
---|---|
US (6) | US8722660B2 (pt) |
EP (2) | EP3533797B1 (pt) |
JP (1) | JP5689454B2 (pt) |
KR (1) | KR101735868B1 (pt) |
CN (1) | CN102844320B (pt) |
AU (1) | AU2011216404B2 (pt) |
BR (1) | BR112012020311B1 (pt) |
CA (1) | CA2790284C (pt) |
CL (1) | CL2012002250A1 (pt) |
CO (1) | CO6592104A2 (pt) |
CR (1) | CR20120448A (pt) |
CY (1) | CY1121792T1 (pt) |
DK (1) | DK2540728T3 (pt) |
DO (1) | DOP2012000224A (pt) |
EA (1) | EA020724B1 (pt) |
EC (1) | ECSP12012160A (pt) |
ES (1) | ES2733221T3 (pt) |
GE (1) | GEP20146202B (pt) |
HR (1) | HRP20190947T1 (pt) |
HU (1) | HUE043514T2 (pt) |
IL (1) | IL221442A0 (pt) |
LT (1) | LT2540728T (pt) |
MA (1) | MA34064B1 (pt) |
ME (1) | ME03410B (pt) |
MX (1) | MX353500B (pt) |
MY (1) | MY164776A (pt) |
NZ (1) | NZ602089A (pt) |
PE (1) | PE20130184A1 (pt) |
PL (1) | PL2540728T3 (pt) |
PT (1) | PT2540728T (pt) |
RS (1) | RS58796B1 (pt) |
SG (1) | SG183304A1 (pt) |
SI (1) | SI2540728T1 (pt) |
TN (1) | TN2012000401A1 (pt) |
WO (1) | WO2011102399A1 (pt) |
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PE20131304A1 (es) * | 2010-08-11 | 2013-11-14 | Millennium Pharm Inc | Heteroarilos y sus usos |
JP6569908B2 (ja) | 2014-01-31 | 2019-09-04 | カルナバイオサイエンス株式会社 | 抗がん剤組成物 |
TW201620879A (zh) | 2014-04-28 | 2016-06-16 | 杜邦股份有限公司 | 除草性經取代之3-苯基-4-氟基苯甲醯基吡唑 |
US10174032B2 (en) * | 2014-05-05 | 2019-01-08 | Signalrx Pharmaceuticals, Inc. | Heterocyclic compound classes for signaling modulation |
KR102006320B1 (ko) | 2015-12-07 | 2019-08-02 | 지머젠 인코포레이티드 | Htp 게놈 공학 플랫폼에 의한 미생물 균주 개량 |
CA3008171A1 (en) | 2015-12-22 | 2017-06-29 | SHY Therapeutics LLC | Compounds for the treatment of cancer and inflammatory disease |
PT3436463T (pt) * | 2016-03-28 | 2021-09-06 | Takeda Pharmaceuticals Co | Formas cristalinas de 2-[(2s)-1-azabiciclo[2.2.2]oct-2- il]-6-(3-metil-1h-pirazol-4-il)tieno[3,2-d]pirimidin-4(3h)- ona hemihidratada |
EA035560B1 (ru) * | 2016-07-28 | 2020-07-07 | Такеда Фармасьютикал Компани Лимитед | Кристаллические формы гемигидрата 2-[(2s)-1-азабицикло[2.2.2]окт-2-ил]-6-(3-метил-1h-пиразол-4-ил)тиено[3,2- d]пиримидин-4(3h)-она |
US11020396B2 (en) | 2016-11-08 | 2021-06-01 | Cancer Research Technology Limited | Pyrimidinone derivatives as Cdc7 inhibitors |
US11155879B2 (en) * | 2017-03-01 | 2021-10-26 | Takeda Pharmaceutical Company Limited | Method of predicting effects of CDC7 inhibitor |
CN110381950B (zh) * | 2017-05-21 | 2020-09-04 | 南京正济医药研究有限公司 | 作为抗癌剂的取代的[5,6]环-4(3h)-嘧啶酮 |
IL310023A (en) | 2017-06-21 | 2024-03-01 | SHY Therapeutics LLC | Compounds interacting with the RAS superfamily for the treatment of cancer, inflammation, RAS pathology and fibrotic diseases |
CA3095264A1 (en) * | 2018-04-02 | 2019-10-10 | Takeda Pharmaceutical Company Limited | Process for the synthesis of 2-[(2s)-1-azabicyclo[2.2.2]oct-2-yl]-6- (3-methyl-1 h-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3h)-one |
TW202016316A (zh) | 2018-06-19 | 2020-05-01 | 日商武田藥品工業股份有限公司 | 癌症治療方法 |
CA3106557A1 (en) * | 2018-07-19 | 2020-01-23 | Takeda Pharmaceutical Company Limited | Pharmaceutical compositions with a cdc7 inhibitor |
SG11202113212YA (en) * | 2019-05-30 | 2021-12-30 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Tetracyclic compounds as cdc7 inhibitors |
CA3146792A1 (en) * | 2019-07-19 | 2021-01-28 | Takeda Pharmaceutical Company Limited | Combination therapy for cancer treatment |
US20220389026A1 (en) * | 2019-08-20 | 2022-12-08 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Tetracyclic compound used as cdc7 inhibitor |
EP4069369A4 (en) * | 2019-12-06 | 2024-02-14 | Schroedinger Inc | CYCLIC COMPOUNDS AND METHODS OF USE THEREOF |
CN116490507A (zh) * | 2020-09-10 | 2023-07-25 | 薛定谔公司 | 用于治疗癌症的杂环包缩合cdc7激酶抑制剂 |
CN116472046A (zh) * | 2020-11-30 | 2023-07-21 | 正大天晴药业集团股份有限公司 | 作为Cdc7抑制剂的盐型及其晶型 |
CN112661770B (zh) * | 2020-12-24 | 2022-11-08 | 南京正济医药研究有限公司 | 一种化合物及利用其制备取代的[5,6]环-4(3h)-嘧啶酮化合物的方法 |
WO2022167999A1 (en) | 2021-02-08 | 2022-08-11 | Takeda Pharmaceutical Company Limited | Combination therapy for cancer treatment |
TW202300150A (zh) * | 2021-03-18 | 2023-01-01 | 美商薛定諤公司 | 環狀化合物及其使用方法 |
TW202330552A (zh) * | 2021-10-13 | 2023-08-01 | 美商雷密克斯醫療公司 | 調節剪接之化合物及方法 |
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2011
- 2011-02-16 GE GEAP201112855A patent/GEP20146202B/en unknown
- 2011-02-16 SG SG2012059994A patent/SG183304A1/en unknown
- 2011-02-16 PT PT11744685T patent/PT2540728T/pt unknown
- 2011-02-16 EP EP19168244.2A patent/EP3533797B1/en active Active
- 2011-02-16 DK DK11744685.6T patent/DK2540728T3/da active
- 2011-02-16 HU HUE11744685A patent/HUE043514T2/hu unknown
- 2011-02-16 PE PE2012001253A patent/PE20130184A1/es active IP Right Grant
- 2011-02-16 EA EA201290800A patent/EA020724B1/ru unknown
- 2011-02-16 MX MX2012009602A patent/MX353500B/es active IP Right Grant
- 2011-02-16 MY MYPI2012003715A patent/MY164776A/en unknown
- 2011-02-16 CN CN201180019478.3A patent/CN102844320B/zh active Active
- 2011-02-16 WO PCT/JP2011/053303 patent/WO2011102399A1/ja active Application Filing
- 2011-02-16 SI SI201131722T patent/SI2540728T1/sl unknown
- 2011-02-16 KR KR1020127024086A patent/KR101735868B1/ko active IP Right Grant
- 2011-02-16 EP EP11744685.6A patent/EP2540728B1/en active Active
- 2011-02-16 LT LTEP11744685.6T patent/LT2540728T/lt unknown
- 2011-02-16 RS RS20190639A patent/RS58796B1/sr unknown
- 2011-02-16 ME MEP-2019-152A patent/ME03410B/me unknown
- 2011-02-16 ES ES11744685T patent/ES2733221T3/es active Active
- 2011-02-16 AU AU2011216404A patent/AU2011216404B2/en active Active
- 2011-02-16 US US13/578,959 patent/US8722660B2/en active Active
- 2011-02-16 CA CA2790284A patent/CA2790284C/en active Active
- 2011-02-16 NZ NZ602089A patent/NZ602089A/en unknown
- 2011-02-16 MA MA35205A patent/MA34064B1/fr unknown
- 2011-02-16 PL PL11744685T patent/PL2540728T3/pl unknown
- 2011-02-16 JP JP2012500632A patent/JP5689454B2/ja active Active
- 2011-02-16 BR BR112012020311-8A patent/BR112012020311B1/pt active IP Right Grant
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2012
- 2012-08-09 TN TNP2012000401A patent/TN2012000401A1/en unknown
- 2012-08-14 IL IL221442A patent/IL221442A0/en active IP Right Grant
- 2012-08-14 CL CL2012002250A patent/CL2012002250A1/es unknown
- 2012-08-15 DO DO2012000224A patent/DOP2012000224A/es unknown
- 2012-08-29 CR CR20120448A patent/CR20120448A/es unknown
- 2012-09-13 CO CO12158066A patent/CO6592104A2/es active IP Right Grant
- 2012-09-17 EC ECSP12012160 patent/ECSP12012160A/es unknown
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2014
- 2014-03-24 US US14/223,259 patent/US8921354B2/en active Active
- 2014-03-24 US US14/223,329 patent/US8933069B2/en active Active
- 2014-12-10 US US14/566,157 patent/US9388195B2/en active Active
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2016
- 2016-06-08 US US15/176,893 patent/US9655900B2/en active Active
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2017
- 2017-04-11 US US15/484,755 patent/US20170209452A1/en not_active Abandoned
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2019
- 2019-05-23 HR HRP20190947TT patent/HRP20190947T1/hr unknown
- 2019-07-09 CY CY20191100721T patent/CY1121792T1/el unknown
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