ME03410B - Heterociklična jedinjenja - Google Patents
Heterociklična jedinjenjaInfo
- Publication number
- ME03410B ME03410B MEP-2019-152A MEP2019152A ME03410B ME 03410 B ME03410 B ME 03410B ME P2019152 A MEP2019152 A ME P2019152A ME 03410 B ME03410 B ME 03410B
- Authority
- ME
- Montenegro
- Prior art keywords
- heterocyclic compound
- heterocyclic
- compound
- Prior art date
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010031899 | 2010-02-17 | ||
| JP2010131950 | 2010-06-09 | ||
| EP11744685.6A EP2540728B1 (en) | 2010-02-17 | 2011-02-16 | Heterocyclic compound |
| PCT/JP2011/053303 WO2011102399A1 (ja) | 2010-02-17 | 2011-02-16 | 複素環化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME03410B true ME03410B (me) | 2020-01-20 |
Family
ID=44482985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2019-152A ME03410B (me) | 2010-02-17 | 2011-02-16 | Heterociklična jedinjenja |
Country Status (37)
| Country | Link |
|---|---|
| US (6) | US8722660B2 (me) |
| EP (2) | EP3533797B1 (me) |
| JP (1) | JP5689454B2 (me) |
| KR (1) | KR101735868B1 (me) |
| CN (1) | CN102844320B (me) |
| AU (1) | AU2011216404B2 (me) |
| BR (1) | BR112012020311B1 (me) |
| CA (1) | CA2790284C (me) |
| CL (1) | CL2012002250A1 (me) |
| CO (1) | CO6592104A2 (me) |
| CR (1) | CR20120448A (me) |
| CY (1) | CY1121792T1 (me) |
| DK (1) | DK2540728T3 (me) |
| DO (1) | DOP2012000224A (me) |
| EA (1) | EA020724B1 (me) |
| EC (1) | ECSP12012160A (me) |
| ES (1) | ES2733221T3 (me) |
| GE (1) | GEP20146202B (me) |
| HR (1) | HRP20190947T1 (me) |
| HU (1) | HUE043514T2 (me) |
| IL (1) | IL221442A0 (me) |
| LT (1) | LT2540728T (me) |
| MA (1) | MA34064B1 (me) |
| ME (1) | ME03410B (me) |
| MX (1) | MX353500B (me) |
| MY (1) | MY164776A (me) |
| NZ (1) | NZ602089A (me) |
| PE (1) | PE20130184A1 (me) |
| PH (1) | PH12012501650B1 (me) |
| PL (1) | PL2540728T3 (me) |
| PT (1) | PT2540728T (me) |
| RS (1) | RS58796B1 (me) |
| SG (1) | SG183304A1 (me) |
| SI (1) | SI2540728T1 (me) |
| SM (1) | SMT201900385T1 (me) |
| TN (1) | TN2012000401A1 (me) |
| WO (1) | WO2011102399A1 (me) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012021696A1 (en) * | 2010-08-11 | 2012-02-16 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| JP6569908B2 (ja) | 2014-01-31 | 2019-09-04 | カルナバイオサイエンス株式会社 | 抗がん剤組成物 |
| TW201620879A (zh) | 2014-04-28 | 2016-06-16 | 杜邦股份有限公司 | 除草性經取代之３－苯基－４－氟基苯甲醯基吡唑 |
| US10174032B2 (en) * | 2014-05-05 | 2019-01-08 | Signalrx Pharmaceuticals, Inc. | Heterocyclic compound classes for signaling modulation |
| JP6605042B2 (ja) | 2015-12-07 | 2019-11-13 | ザイマージェン インコーポレイテッド | Ｈｔｐゲノム操作プラットフォームによる微生物株の改良 |
| JP7114076B2 (ja) | 2015-12-22 | 2022-08-08 | シャイ・セラピューティクス・エルエルシー | がん及び炎症性疾患の処置のための化合物 |
| WO2017172565A1 (en) | 2016-03-28 | 2017-10-05 | Takeda Pharmaceutical Company Limited | Crystalline forms of 2-[(2s)-1-azabicyclo[2.2.2]oct-2-yl]-6-(3-methyl-1h- pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3h)-one hemihydrate |
| EA035560B1 (ru) * | 2016-07-28 | 2020-07-07 | Такеда Фармасьютикал Компани Лимитед | Кристаллические формы гемигидрата 2-[(2s)-1-азабицикло[2.2.2]окт-2-ил]-6-(3-метил-1h-пиразол-4-ил)тиено[3,2- d]пиримидин-4(3h)-она |
| AU2017359561B2 (en) | 2016-11-08 | 2022-02-03 | Cancer Research Technology Limited | Pyrimidinone derivatives as Cdc7 inhibitors |
| EP3589747B1 (en) * | 2017-03-01 | 2021-05-19 | Takeda Pharmaceutical Company Limited | Method of predicting effects of cdc7 inhibitor |
| CN112409373A (zh) * | 2017-05-21 | 2021-02-26 | 南京正济医药研究有限公司 | 作为抗癌剂的取代的[5,6]环-4(3h)-嘧啶酮 |
| CA3066939A1 (en) | 2017-06-21 | 2018-12-27 | SHY Therapeutics LLC | Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease |
| EP3774816A1 (en) * | 2018-04-02 | 2021-02-17 | Takeda Pharmaceutical Company Limited | Process for the synthesis of 2-[(2s)-1-azabicyclo[2.2.2]oct-2-yl]-6- (3-methyl-1 h-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3h)-one |
| TWI846703B (zh) | 2018-06-19 | 2024-07-01 | 日商武田藥品工業股份有限公司 | 癌症治療方法 |
| AU2019305828A1 (en) * | 2018-07-19 | 2021-01-28 | Takeda Pharmaceutical Company Limited | Pharmaceutical compositions with a CDC7 inhibitor |
| JP7407461B2 (ja) | 2018-12-19 | 2024-01-04 | シャイ・セラピューティクス・エルエルシー | がん、炎症性疾患、ｒａｓ病、及び線維性疾患の処置のためのｒａｓスーパーファミリーと相互作用する化合物 |
| PH12021552787A1 (en) * | 2019-05-30 | 2022-09-28 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Tetracyclic compounds as cdc7 inhibitors |
| CA3146792A1 (en) * | 2019-07-19 | 2021-01-28 | Takeda Pharmaceutical Company Limited | Combination therapy for cancer treatment |
| JP2022546294A (ja) * | 2019-08-20 | 2022-11-04 | チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド | Ｃｄｃ７阻害剤として使用される四環式化合物 |
| EP4069369A4 (en) * | 2019-12-06 | 2024-02-14 | Schrödinger, Inc. | CYCLIC COMPOUNDS AND METHODS OF USE THEREOF |
| US20230365584A1 (en) * | 2020-09-10 | 2023-11-16 | Schrödinger, Inc. | Heterocyclic pericondensed cdc7 kinase inhibitors for the treatment of cancer |
| CN116472046B (zh) * | 2020-11-30 | 2025-03-28 | 正大天晴药业集团股份有限公司 | 作为Cdc7抑制剂的盐型及其晶型 |
| CN112661770B (zh) * | 2020-12-24 | 2022-11-08 | 南京正济医药研究有限公司 | 一种化合物及利用其制备取代的[5,6]环-4(3h)-嘧啶酮化合物的方法 |
| WO2022167999A1 (en) | 2021-02-08 | 2022-08-11 | Takeda Pharmaceutical Company Limited | Combination therapy for cancer treatment |
| CN117120447A (zh) * | 2021-03-18 | 2023-11-24 | 薛定谔公司 | 环状化合物和其使用方法 |
| TW202300150A (zh) * | 2021-03-18 | 2023-01-01 | 美商薛定諤公司 | 環狀化合物及其使用方法 |
| WO2023064879A1 (en) * | 2021-10-13 | 2023-04-20 | Remix Therapeutics Inc. | Compounds and methods for modulating nucleic acid splicing |
| WO2025160538A1 (en) * | 2024-01-26 | 2025-07-31 | The Board Of Regents Of The University Of Texas System | Compositions and methods for treating hair graying and loss associated with aging |
| WO2025168620A1 (en) | 2024-02-07 | 2025-08-14 | Bayer Aktiengesellschaft | Heteroaryl-substituted 4,5-dihydro-1h-2,4,5-oxadiazines as novel fungicides |
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| DE602004014163D1 (de) * | 2003-08-08 | 2008-07-10 | Pfizer Italia Srl | Pyrimidylpyrrolderivate, die als kinaseinhibitoren wirken |
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| US7618982B2 (en) | 2005-12-19 | 2009-11-17 | Nerviano Medical Sciences S.R.L. | Heteroarylpyrrolopyridinones active as kinase inhibitors |
| KR100846988B1 (ko) | 2006-03-06 | 2008-07-16 | 제일약품주식회사 | 신규한 티에노피리미딘 유도체 또는 이의 약학적으로허용가능한 염, 이의 제조방법 및 이를 함유하는 약학조성물 |
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| US20090118276A1 (en) | 2007-11-02 | 2009-05-07 | Wyeth | Thienopyrimidines, thienopyridines, and pyrrolopyrimidines as b-raf inhibitors |
| EP2276747A1 (en) | 2008-03-11 | 2011-01-26 | Cellzome Limited | Sulfonamides as zap-70 inhibitors |
| PE20091928A1 (es) | 2008-05-29 | 2009-12-31 | Bristol Myers Squibb Co | Tienopirimidinas hidroxisustituidas como antagonistas de receptor-1 de hormona concentradora de melanina no basicos |
| NZ590385A (en) | 2008-06-26 | 2012-11-30 | Dana Farber Cancer Inst Inc | Signatures and determinants associated with metastasis and methods of use thereof |
| JP5645839B2 (ja) | 2009-03-05 | 2014-12-24 | 武田薬品工業株式会社 | Ｃｄｃ７キナーゼ阻害剤としてのチエノピリミジン |
| WO2010126002A1 (ja) | 2009-04-28 | 2010-11-04 | 塩野義製薬株式会社 | ヘテロ環スルホンアミド化合物を含有する医薬 |
| TW201111378A (en) | 2009-09-11 | 2011-04-01 | Bayer Schering Pharma Ag | Substituted (heteroarylmethyl) thiohydantoins |
| CN102481294A (zh) | 2009-09-11 | 2012-05-30 | 拜耳医药股份有限公司 | 作为抗癌药物的取代(杂芳基甲基)乙内酰硫脲 |
| AR079343A1 (es) | 2009-12-21 | 2012-01-18 | Lilly Co Eli | Compuesto de acido 2-amino-4-(4h-1,2,4-triazol-3-ilsulfanil)biciclo[3.1.0]hexano-2,6-dicarboxilico, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar un trastorno psiquiatrico |
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2011
- 2011-02-16 ME MEP-2019-152A patent/ME03410B/me unknown
- 2011-02-16 AU AU2011216404A patent/AU2011216404B2/en active Active
- 2011-02-16 WO PCT/JP2011/053303 patent/WO2011102399A1/ja not_active Ceased
- 2011-02-16 PE PE2012001253A patent/PE20130184A1/es active IP Right Grant
- 2011-02-16 GE GEAP201112855A patent/GEP20146202B/en unknown
- 2011-02-16 JP JP2012500632A patent/JP5689454B2/ja active Active
- 2011-02-16 SG SG2012059994A patent/SG183304A1/en unknown
- 2011-02-16 PH PH1/2012/501650A patent/PH12012501650B1/en unknown
- 2011-02-16 SI SI201131722T patent/SI2540728T1/sl unknown
- 2011-02-16 MA MA35205A patent/MA34064B1/fr unknown
- 2011-02-16 MY MYPI2012003715A patent/MY164776A/en unknown
- 2011-02-16 US US13/578,959 patent/US8722660B2/en active Active
- 2011-02-16 ES ES11744685T patent/ES2733221T3/es active Active
- 2011-02-16 NZ NZ602089A patent/NZ602089A/en unknown
- 2011-02-16 PT PT11744685T patent/PT2540728T/pt unknown
- 2011-02-16 DK DK11744685.6T patent/DK2540728T3/da active
- 2011-02-16 CA CA2790284A patent/CA2790284C/en active Active
- 2011-02-16 HU HUE11744685A patent/HUE043514T2/hu unknown
- 2011-02-16 RS RS20190639A patent/RS58796B1/sr unknown
- 2011-02-16 PL PL11744685T patent/PL2540728T3/pl unknown
- 2011-02-16 MX MX2012009602A patent/MX353500B/es active IP Right Grant
- 2011-02-16 EP EP19168244.2A patent/EP3533797B1/en active Active
- 2011-02-16 CN CN201180019478.3A patent/CN102844320B/zh active Active
- 2011-02-16 BR BR112012020311-8A patent/BR112012020311B1/pt active IP Right Grant
- 2011-02-16 EP EP11744685.6A patent/EP2540728B1/en active Active
- 2011-02-16 KR KR1020127024086A patent/KR101735868B1/ko active Active
- 2011-02-16 HR HRP20190947TT patent/HRP20190947T1/hr unknown
- 2011-02-16 LT LTEP11744685.6T patent/LT2540728T/lt unknown
- 2011-02-16 EA EA201290800A patent/EA020724B1/ru unknown
- 2011-02-16 SM SM20190385T patent/SMT201900385T1/it unknown
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2012
- 2012-08-09 TN TNP2012000401A patent/TN2012000401A1/en unknown
- 2012-08-14 IL IL221442A patent/IL221442A0/en active IP Right Grant
- 2012-08-14 CL CL2012002250A patent/CL2012002250A1/es unknown
- 2012-08-15 DO DO2012000224A patent/DOP2012000224A/es unknown
- 2012-08-29 CR CR20120448A patent/CR20120448A/es unknown
- 2012-09-13 CO CO12158066A patent/CO6592104A2/es active IP Right Grant
- 2012-09-17 EC ECSP12012160 patent/ECSP12012160A/es unknown
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2014
- 2014-03-24 US US14/223,259 patent/US8921354B2/en active Active
- 2014-03-24 US US14/223,329 patent/US8933069B2/en active Active
- 2014-12-10 US US14/566,157 patent/US9388195B2/en active Active
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2016
- 2016-06-08 US US15/176,893 patent/US9655900B2/en active Active
-
2017
- 2017-04-11 US US15/484,755 patent/US20170209452A1/en not_active Abandoned
-
2019
- 2019-07-09 CY CY20191100721T patent/CY1121792T1/el unknown
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