HUP0300425A2 - Eljárás taxánszármazékok szelektív elżállítására - Google Patents

Eljárás taxánszármazékok szelektív elżállítására

Info

Publication number
HUP0300425A2
HUP0300425A2 HU0300425A HUP0300425A HUP0300425A2 HU P0300425 A2 HUP0300425 A2 HU P0300425A2 HU 0300425 A HU0300425 A HU 0300425A HU P0300425 A HUP0300425 A HU P0300425A HU P0300425 A2 HUP0300425 A2 HU P0300425A2
Authority
HU
Hungary
Prior art keywords
optionally
group
acyloxy
oxo
protected hydroxy
Prior art date
Application number
HU0300425A
Other languages
English (en)
Inventor
Paul Clark
Robert A. Holton
Zhuming Zhang
Original Assignee
Florida State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27368950&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0300425(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Florida State University filed Critical Florida State University
Publication of HUP0300425A2 publication Critical patent/HUP0300425A2/hu
Publication of HUP0300425A3 publication Critical patent/HUP0300425A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Soil Working Implements (AREA)
  • Fats And Perfumes (AREA)
  • Percussion Or Vibration Massage (AREA)

Abstract

A találmány tárgya eljárás 7- és vagy 10-helyzetben szelektívenacilezett vagy szililezett, továbbá C(7)-ketállá alakított taxánokelőállítására egy 10-hidroxi- vagy 7,10-dihidroxi-taxán ismertacilezőszerekkel legfeljebb 1 ekvivalensnél kevesebb bázisjelenlétében végzett acilezése, illetve egy szilil-amiddal vagydiszilil-amiddal történő szililezése, majd ezt követő továbbiacilezése, szililezése és/vagy ketállá reagáltatása által. A találmánytárgyát képezik az (I) általános képletű taxánok is - ahol R1hidrogénatom, adott esetben védett hidroxicsoport, vagy R1 és R14 vagyR2 együtt karbonátot képez; R2 oxo-, acil-oxi- vagy adott esetbenvédett hidroxicsoport, vagy R2 és R1 együtt karbonátot képez; R4 adottesetben védett hidroxi-, karbohidril-oxi vagy acil-oxi-csoport; R7 -OSiRJRKRL általános képletű csoport, amelyben RJ, RK és RL egymástólfüggetlenül karbohidrid- vagy heteroarilcsoport, azzal a megkötéssel,hogy ha mind alkilcsoport, akkor egyikük legalább 4 szénatomos; R9 ésR10 hidrogénatom, oxo-, karbohidril-oxi-, acil-oxi- vagy adott esetbenvédett hidroxicsoport; R13 hidroxicsoport, adott esetben fémsó vagyammóniumsó formájában vagy védett formában, vagy oxocsoport; és R14hidrogénatom, oxo-, acil-oxi- vagy adott esetben védetthidroxicsoport, vagy R14 és R1 együtt karbonátot képez . Ó
HU0300425A 1997-08-18 1998-08-17 Process for selective derivatization of taxanes HUP0300425A3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US5600097P 1997-08-18 1997-08-18
US8126598P 1998-04-09 1998-04-09
US09/063,477 US7288665B1 (en) 1997-08-18 1998-04-20 Process for selective derivatization of taxanes
PCT/US1998/017016 WO1999009021A1 (en) 1997-08-18 1998-08-17 Process for selective derivatization of taxanes

Publications (2)

Publication Number Publication Date
HUP0300425A2 true HUP0300425A2 (hu) 2003-09-29
HUP0300425A3 HUP0300425A3 (en) 2005-12-28

Family

ID=27368950

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0300425A HUP0300425A3 (en) 1997-08-18 1998-08-17 Process for selective derivatization of taxanes

Country Status (25)

Country Link
US (5) US7288665B1 (hu)
EP (6) EP1193262A1 (hu)
JP (1) JP2001504864A (hu)
KR (1) KR100596989B1 (hu)
CN (3) CN100351246C (hu)
AT (3) ATE326455T1 (hu)
AU (1) AU744987B2 (hu)
BR (1) BR9806145A (hu)
CA (2) CA2597799A1 (hu)
CY (1) CY1105399T1 (hu)
CZ (1) CZ296580B6 (hu)
DE (3) DE69837684T2 (hu)
DK (3) DK1170293T3 (hu)
ES (3) ES2259646T3 (hu)
HU (1) HUP0300425A3 (hu)
ID (1) ID21654A (hu)
IL (3) IL129386A0 (hu)
NO (4) NO325139B1 (hu)
NZ (1) NZ335156A (hu)
PL (3) PL332723A1 (hu)
PT (3) PT956284E (hu)
RU (1) RU2225402C2 (hu)
SG (1) SG97986A1 (hu)
WO (1) WO1999009021A1 (hu)
ZA (1) ZA987394B (hu)

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IL129386A0 (en) 2000-02-17
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PL332723A1 (en) 1999-10-11
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CN1974563A (zh) 2007-06-06
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HUP0300425A3 (en) 2005-12-28
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RU2225402C2 (ru) 2004-03-10
KR20000068782A (ko) 2000-11-25
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CN100351246C (zh) 2007-11-28
US6706896B1 (en) 2004-03-16
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CN1239476A (zh) 1999-12-22
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ZA987394B (en) 1999-05-14
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