SG97986A1 - Process for selective derivatization of taxanes - Google Patents

Process for selective derivatization of taxanes

Info

Publication number
SG97986A1
SG97986A1 SG200006873A SG200006873A SG97986A1 SG 97986 A1 SG97986 A1 SG 97986A1 SG 200006873 A SG200006873 A SG 200006873A SG 200006873 A SG200006873 A SG 200006873A SG 97986 A1 SG97986 A1 SG 97986A1
Authority
SG
Singapore
Prior art keywords
sup
taxanes
hydroxytaxane
acyloxy
selective derivatization
Prior art date
Application number
SG200006873A
Other languages
English (en)
Inventor
A Holton Robert
Zhang Zhuming
A Clark Paul
Original Assignee
Univ Florida State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27368950&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG97986(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Florida State filed Critical Univ Florida State
Publication of SG97986A1 publication Critical patent/SG97986A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Soil Working Implements (AREA)
  • Fats And Perfumes (AREA)
  • Percussion Or Vibration Massage (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SG200006873A 1997-08-18 1998-08-17 Process for selective derivatization of taxanes SG97986A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5600097P 1997-08-18 1997-08-18
US8126598P 1998-04-09 1998-04-09
US09/063,477 US7288665B1 (en) 1997-08-18 1998-04-20 Process for selective derivatization of taxanes

Publications (1)

Publication Number Publication Date
SG97986A1 true SG97986A1 (en) 2003-08-20

Family

ID=27368950

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200006873A SG97986A1 (en) 1997-08-18 1998-08-17 Process for selective derivatization of taxanes

Country Status (25)

Country Link
US (5) US7288665B1 (hu)
EP (6) EP1795528A1 (hu)
JP (1) JP2001504864A (hu)
KR (1) KR100596989B1 (hu)
CN (3) CN1974563A (hu)
AT (3) ATE326455T1 (hu)
AU (1) AU744987B2 (hu)
BR (1) BR9806145A (hu)
CA (2) CA2597799A1 (hu)
CY (1) CY1105399T1 (hu)
CZ (1) CZ296580B6 (hu)
DE (3) DE69834584T2 (hu)
DK (3) DK0956284T3 (hu)
ES (3) ES2274579T3 (hu)
HU (1) HUP0300425A3 (hu)
ID (1) ID21654A (hu)
IL (3) IL129386A0 (hu)
NO (4) NO325139B1 (hu)
NZ (1) NZ335156A (hu)
PL (3) PL193674B1 (hu)
PT (3) PT956284E (hu)
RU (1) RU2225402C2 (hu)
SG (1) SG97986A1 (hu)
WO (1) WO1999009021A1 (hu)
ZA (1) ZA987394B (hu)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750736A (en) * 1996-07-11 1998-05-12 Napro Biotherapeutics, Inc. Method for acylating 10-deacetylbaccatin III selectively at the c-10 position
US7288665B1 (en) 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
IT1308636B1 (it) * 1999-03-02 2002-01-09 Indena Spa Procedimento per la preparazione di tassani da 10-desacetilbaccatinaiii.
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
HUP0200750A3 (en) 2000-02-02 2005-02-28 Univ Florida State Res Found C10 heterosubstituted acetate taxanes as antitumor agents and pharmaceutical compositions containing them and their use
CZ20013429A3 (cs) 2000-02-02 2002-04-17 Florida State University Research Foundation, Inc. Taxany substituované v poloze C7 karbonátem jako protinádorová činidla
KR20020002417A (ko) 2000-02-02 2002-01-09 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 항종양제로서의 ｃ7 카르바모일옥시 치환된 탁산
EP1165551B1 (en) 2000-02-02 2008-07-16 Florida State University Research Foundation, Inc. C10 carbamoyloxy substituted taxanes as antitumor agents
AU776765B2 (en) 2000-02-02 2004-09-23 Florida State University Research Foundation, Inc. C7 heterosubstituted acetate taxanes as antitumor agents
HUP0200759A3 (en) 2000-02-02 2002-10-28 Univ Florida State Res Found C10 carbonate substituted taxanes as antitumor agents and pharmaceutical compositions containing them and their use
CO5280224A1 (es) 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
US6362217B2 (en) * 2000-03-17 2002-03-26 Bristol-Myers Squibb Company Taxane anticancer agents
IT1320107B1 (it) * 2000-11-28 2003-11-18 Indena Spa Procedimento per la preparazione di derivati tassanici.
IT1319682B1 (it) * 2000-12-06 2003-10-23 Indena Spa Procedimento di sintesi del paclitaxel.
US7351542B2 (en) 2002-05-20 2008-04-01 The Regents Of The University Of California Methods of modulating tubulin deacetylase activity
PT1530465E (pt) 2002-06-26 2010-01-05 Medigene Ag Processo para produção de uma preparação lipossomal catiónica que compreende um composto lipofílico
EP2390262A1 (en) 2003-05-16 2011-11-30 Intermune, Inc. Synthetic chemokine receptor ligands and methods of use thereof
CN1303077C (zh) * 2004-01-16 2007-03-07 桂林晖昂生化药业有限责任公司 合成紫杉烷的制备工艺
HN2005000054A (es) 2004-02-13 2009-02-18 Florida State University Foundation Inc Taxanos sustituidos con esteres de ciclopentilo en c10
GT200500041A (es) 2004-03-05 2005-10-24 Taxanos con sustituyente lactiloxilo en el c7
EA200601898A1 (ru) * 2004-05-14 2007-02-27 Иммьюноджен, Инк. Простой способ синтеза соединений баккатина iii
WO2006089218A2 (en) 2005-02-17 2006-08-24 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for modulating angiogenesis
US7667055B2 (en) * 2005-06-10 2010-02-23 Florida State University Research Foundation, Inc. Processes for the production of polycyclic fused ring compounds
BRPI0611737A2 (pt) * 2005-06-10 2011-12-27 Univ Florida State Res Found processos para a preparaÇço de docetaxel
AU2007228984B2 (en) 2006-03-22 2012-05-03 Syncore Biotechnology Co., Ltd Treatment of triple receptor negative breast cancer
US7847111B2 (en) * 2006-06-19 2010-12-07 Canada Inc. Semi-synthetic route for the preparation of paclitaxel, docetaxel, and 10-deacetylbaccatin III from 9-dihydro-13-acetylbaccatin III
PL210984B1 (pl) * 2006-10-31 2012-03-30 Inst Farmaceutyczny Sposób wytwarzania docetakselu
WO2008106491A2 (en) * 2007-02-27 2008-09-04 University Of Utah Research Foundation Peptides that interact with topoisomerase i and methods thereof
JP4833126B2 (ja) * 2007-03-26 2011-12-07 Ｎｔｎ株式会社 潤滑剤劣化検出装置および検出装置付き軸受
CN101274923B (zh) * 2007-03-27 2011-02-02 中国科学院大连化学物理研究所 一种制备紫杉醇，巴卡亭ⅲ及其衍生物的方法
CN101274924B (zh) * 2007-03-27 2010-11-10 中国科学院大连化学物理研究所 一种制备紫杉醇及其衍生物的方法
WO2009040829A1 (en) * 2007-09-27 2009-04-02 Benzochem Lifescience (P) Limited A novel process for the preparation of docetaxel
WO2009145981A1 (en) 2008-03-31 2009-12-03 Florida State University Research Foundation, Inc. C(10) ethyl ester and c(10) cyclopropyl ester substituted taxanes
WO2009143454A2 (en) 2008-05-22 2009-11-26 Kereos, Inc. Combination antitumor therapy
WO2010005850A1 (en) 2008-07-08 2010-01-14 The J. David Gladstone Institutes Methods and compositions for modulating angiogenesis
CN101863861A (zh) * 2009-04-16 2010-10-20 山东靶点药物研究有限公司 一种简便高效地制备紫杉醇类似物Larotaxel的方法
US8791279B2 (en) * 2010-12-13 2014-07-29 Yung Shin Pharm. Ind. Co., Ltd. Process for preparing taxoids from baccatin derivatives using lewis acid catalyst
US8829210B2 (en) 2011-04-01 2014-09-09 Shilpa Medicare Limited Process for preparing docetaxel and its hydrate
US20130090484A1 (en) * 2011-10-11 2013-04-11 Scinopharm Taiwan Ltd. Process for making an intermediate of cabazitaxel
CN103159704B (zh) * 2011-12-12 2015-06-10 上海佰霖国际贸易有限公司 卡巴他赛中间体及卡巴他赛中间体的制备方法
EP3539563A1 (en) 2012-07-19 2019-09-18 Redwood Bioscience, Inc. Antibody specific for cd22 and methods of use thereof
KR20150083121A (ko) 2012-11-12 2015-07-16 레드우드 바이오사이언스 인코포레이티드 화합물, 및 컨쥬게이트의 제조방법
IL305629A (en) 2013-02-15 2023-11-01 Univ California Chimeric antigen receptor and methods of using it
JP6410790B2 (ja) 2013-03-14 2018-10-24 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー ミトコンドリアアルデヒドデヒドロゲナーゼ−２調節因子およびその使用方法
CN103145654A (zh) * 2013-04-12 2013-06-12 江苏斯威森生物医药工程研究中心有限公司 一种多西他赛的半合成方法
WO2014191989A1 (en) * 2013-05-26 2014-12-04 Idd Therapeutics Ltd. Conjugate of a taxane and biotin and uses thereof
WO2015081282A1 (en) 2013-11-27 2015-06-04 Redwood Bioscience, Inc. Hydrazinyl-pyrrolo compounds and methods for producing a conjugate
DK3107899T3 (da) 2014-02-19 2020-11-16 Aviv Therapeutics Inc Mitokondriel aldehyddehydrogenase 2 (aldh2)-bindende polycykliske amider og anvendelse deraf til cancerbehandling
MX2016012207A (es) 2014-03-21 2017-04-06 Abbvie Inc Anticuerpos y conjugados de anticuerpo y farmaco anti-egfr.
US10654875B2 (en) 2015-11-12 2020-05-19 The Board Of Trustees Of The Leland Stanford Junior University Cell-penetrating, guanidinium-rich oligophosphotriesters for drug and probe delivery
TWI760319B (zh) 2015-12-30 2022-04-11 杏國新藥股份有限公司 乳癌治療
EP3231421A1 (en) 2016-04-11 2017-10-18 Greenaltech, S.L. Uses of a carotenoid in the treatment or prevention of stress induced conditions
WO2017189432A1 (en) 2016-04-26 2017-11-02 R.P. Scherer Technologies, Llc Antibody conjugates and methods of making and using the same
EP4019007A1 (en) 2016-06-01 2022-06-29 Servier IP UK Limited Formulations of polyalkylene oxide-asparaginase and methods of making and using the same
WO2017214458A2 (en) 2016-06-08 2017-12-14 Abbvie Inc. Anti-cd98 antibodies and antibody drug conjugates
CN109563167A (zh) 2016-06-08 2019-04-02 艾伯维公司 抗b7-h3抗体和抗体药物偶联物
IL300274A (en) 2016-06-08 2023-04-01 Abbvie Inc Antibodies against B7–H3 and conjugates of drug and antibody
JP2019521973A (ja) 2016-06-08 2019-08-08 アッヴィ・インコーポレイテッド 抗ｂｈ７−ｈ３抗体及び抗体薬物コンジュゲート
JP2019524651A (ja) 2016-06-08 2019-09-05 アッヴィ・インコーポレイテッド 抗ｃｄ９８抗体及び抗体薬物コンジュゲート
BR112019013983A2 (pt) 2017-01-05 2020-04-28 Syncore Biotechnology Co Ltd tratamento de câncer pancreático
EP3571229A1 (en) 2017-01-18 2019-11-27 F1 Oncology, Inc. Chimeric antigen receptors against axl or ror2 and methods of use thereof
EP3388082A1 (en) 2017-04-13 2018-10-17 Galera Labs, LLC Combination cancer immunotherapy with pentaaza macrocyclic ring complex
CN111902147A (zh) 2018-01-31 2020-11-06 加莱拉实验室有限责任公司 五氮杂大环状环配合物和基于铂的抗癌剂的组合癌症治疗
CN112368011A (zh) 2018-04-11 2021-02-12 俄亥俄州创新基金会 缓释微粒用于眼用药物递送的方法和组合物
MX2021000644A (es) 2018-07-18 2021-08-19 Manzanita Pharmaceuticals Inc Conjugados para suministrar un agente contra el cancer a las celulas nerviosas, metodos de uso y metodos para la elaboracion de los mismos.
MX2021012003A (es) 2019-04-02 2021-11-04 Kenjockety Biotechnology Inc Anticuerpos multiespecificos contra antigeno de cancer de la bomba de eflujo y composiciones, reactivos, kits y metodos relacionados con los mismos.
KR20220133884A (ko) 2020-01-29 2022-10-05 켄조케티 바이오테크놀러지 인코포레이티드 항-mdr1 항체 및 이의 용도
AU2021284240A1 (en) 2020-06-04 2022-12-08 Kenjockety Biotechnology, Inc. Anti-ABCG2 antibodies and uses thereof
US20230192902A1 (en) 2020-06-04 2023-06-22 Kenjockety Biotechnology, Inc. Abcg2 efflux pump-cancer antigen multi-specific antibodies and compositions, reagents, kits and methods related thereto
EP4208483A1 (en) 2020-09-02 2023-07-12 Kenjockety Biotechnology, Inc. Anti-abcc1 antibodies and uses thereof
CA3203652A1 (en) 2020-11-13 2022-05-19 William Robert ARATHOON Anti-mrp4 (encoded by abcc4 gene) antibodies and uses thereof
AR124681A1 (es) 2021-01-20 2023-04-26 Abbvie Inc Conjugados anticuerpo-fármaco anti-egfr
CA3238353A1 (en) 2021-12-13 2023-06-22 William Robert ARATHOON Anti-abcb1 antibodies
WO2023159220A1 (en) 2022-02-18 2023-08-24 Kenjockety Biotechnology, Inc. Anti-cd47 antibodies

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US5405972A (en) * 1993-07-20 1995-04-11 Florida State University Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes
US5616739A (en) * 1992-10-05 1997-04-01 Rhone-Poulenc Rorer, S.A. Method of preparing taxane derivatives
EP0400971B1 (en) * 1989-05-31 1998-07-29 Florida State University Method for preparation of taxol
EP0629701B1 (en) * 1993-06-15 2000-01-19 Bristol-Myers Squibb Company Enzymatic hydrolysis methods for the preparation of C-10 and C-13 hydroxyl-bearing taxanes, enzymatic esterification method for the preparation of C-10 acyloxy-bearing taxanes, and use thereof in the preparation of C-13 acyloxy-bearing taxanes

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US569666A (en) * 1896-10-20 Brake-beam
FR2601676B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
USRE34277E (en) 1988-04-06 1993-06-08 Centre National De La Recherche Scientifique Process for preparing taxol
JPH01309997A (ja) * 1988-06-09 1989-12-14 Kanto Kasei Kogyo Kk 耐食性に優れた銅−ニッケル−クロム光沢電気めっき方法およびそれにより得られためっき皮膜
US4960790A (en) 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5136060A (en) 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
FR2678930B1 (fr) * 1991-07-10 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
US5399726A (en) 1993-01-29 1995-03-21 Florida State University Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups
US5990325A (en) 1993-03-05 1999-11-23 Florida State University Process for the preparation of 9-desoxotaxol, 9-desoxobaccatin III and analogs thereof
US5350866A (en) 1991-09-23 1994-09-27 Bristol-Myers Squibb Company 10-desacetoxytaxol derivatives
US5489601A (en) 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US5430160A (en) 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US5654447A (en) 1991-09-23 1997-08-05 Florida State University Process for the preparation of 10-desacetoxybaccatin III
US5714513A (en) 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5284864A (en) 1991-09-23 1994-02-08 Florida State University Butenyl substituted taxanes and pharmaceutical compositions containing them
FR2687145B1 (fr) 1992-02-07 1994-03-25 Rhone Poulenc Rorer Sa Nouveaux anhydrides d'acides, leur preparation et leur emplot et
US5200534A (en) 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol
US5416225A (en) 1992-03-30 1995-05-16 Sloan-Kettering Institute For Cancer Research Total synthesis of taxol
US5254703A (en) 1992-04-06 1993-10-19 Florida State University Semi-synthesis of taxane derivatives using metal alkoxides and oxazinones
ES2134847T3 (es) 1992-04-17 1999-10-16 Abbott Lab Derivados de taxol.
US5440056A (en) 1992-04-17 1995-08-08 Abbott Laboratories 9-deoxotaxane compounds
US5269442A (en) * 1992-05-22 1993-12-14 The Cornelius Company Nozzle for a beverage dispensing valve
US5470866A (en) 1992-08-18 1995-11-28 Virginia Polytechnic Institute And State University Method for the conversion of cephalomannine to taxol and for the preparation of n-acyl analogs of taxol
WO1994005282A1 (en) 1992-09-04 1994-03-17 The Scripps Research Institute Water soluble taxol derivatives
US5478854A (en) 1992-10-01 1995-12-26 Bristol-Myers Squibb Company Deoxy taxols
FR2696460B1 (fr) 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
US5412116A (en) 1992-11-06 1995-05-02 Hauser Chemical Research, Inc. Oxidation of glycoside substituted taxanes to taxol or taxol precursors and new taxane compounds formed as intermediates
FR2698363B1 (fr) 1992-11-23 1994-12-30 Rhone Poulenc Rorer Sa Nouveaux dérivés du taxane, leur préparation et les compositions qui les contiennent.
US5380751A (en) 1992-12-04 1995-01-10 Bristol-Myers Squibb Company 6,7-modified paclitaxels
FR2698871B1 (fr) * 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5646176A (en) 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
US5948919A (en) * 1993-02-05 1999-09-07 Napro Biotherapeutics, Inc. Paclitaxel synthesis from precursor compounds and methods of producing the same
FR2702212B1 (fr) 1993-03-02 1995-04-07 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5547981A (en) 1993-03-09 1996-08-20 Enzon, Inc. Taxol-7-carbazates
US5703247A (en) 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
US5475011A (en) 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
US5336684A (en) 1993-04-26 1994-08-09 Hauser Chemical Research, Inc. Oxidation products of cephalomannine
FR2718137B1 (fr) * 1994-04-05 1996-04-26 Rhone Poulenc Rorer Sa Procédé de préparation de trialcoylsilyl-7 baccatine III.
US6100411A (en) * 1994-10-28 2000-08-08 The Research Foundation Of State University Of New York Taxoid anti-tumor agents and pharmaceutical compositions thereof
JPH10508022A (ja) * 1994-10-28 1998-08-04 ザ リサーチ ファウンデーション オブ ステート ユニバーシティ オブ ニューヨーク タキソイド誘導体、それらの製造、およびそれらの抗腫瘍薬としての使用
US5489589A (en) 1994-12-07 1996-02-06 Bristol-Myers Squibb Company Amino acid derivatives of paclitaxel
JPH08253465A (ja) * 1995-03-17 1996-10-01 Dai Ichi Seiyaku Co Ltd 四環性化合物
MA23823A1 (fr) * 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent
US5847170A (en) * 1995-03-27 1998-12-08 Rhone-Poulenc Rorer, S.A. Taxoids, their preparation and pharmaceutical compositions containing them
US5780653A (en) 1995-06-07 1998-07-14 Vivorx Pharmaceuticals, Inc. Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers
US5760251A (en) 1995-08-11 1998-06-02 Sepracor, Inc. Taxol process and compounds
FR2743074B1 (fr) * 1995-12-27 1998-03-27 Seripharm Procede de protection selective des derives de la baccatine et son utilisation dans la synthese des taxanes
US5688977A (en) 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis
WO1997044026A1 (en) * 1996-05-22 1997-11-27 Neuromedica, Inc. Compositions comprising conjugates of cis-docosahexaenoic acid and taxotere
US5773461A (en) 1996-06-06 1998-06-30 Bristol-Myers Squibb Company 7-deoxy-6-substituted paclitaxels
FR2750989B1 (fr) 1996-07-09 1998-09-25 Rhone Poulenc Rorer Sa Procede de monoacylation d'hydroxy taxanes
US5750736A (en) 1996-07-11 1998-05-12 Napro Biotherapeutics, Inc. Method for acylating 10-deacetylbaccatin III selectively at the c-10 position
US5811452A (en) 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US6017935A (en) * 1997-04-24 2000-01-25 Bristol-Myers Squibb Company 7-sulfur substituted paclitaxels
SI0875508T1 (en) * 1997-05-02 2004-04-30 Pharmachemie B.V. Method for the preparation of baccatin III and derivatives thereof from 10-deacetylbaccatin III
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
US5914411A (en) 1998-01-21 1999-06-22 Napro Biotherapeutics, Inc. Alternate method for acylating 10-deacetylbaccatin III selectively at the C-10 position

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0400971B1 (en) * 1989-05-31 1998-07-29 Florida State University Method for preparation of taxol
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US5616739A (en) * 1992-10-05 1997-04-01 Rhone-Poulenc Rorer, S.A. Method of preparing taxane derivatives
EP0629701B1 (en) * 1993-06-15 2000-01-19 Bristol-Myers Squibb Company Enzymatic hydrolysis methods for the preparation of C-10 and C-13 hydroxyl-bearing taxanes, enzymatic esterification method for the preparation of C-10 acyloxy-bearing taxanes, and use thereof in the preparation of C-13 acyloxy-bearing taxanes
US5405972A (en) * 1993-07-20 1995-04-11 Florida State University Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes
US5637732A (en) * 1993-07-20 1997-06-10 Florida State University Tricyclic and tetracyclic taxanes

Also Published As

Publication number Publication date
EP1170292A3 (en) 2002-04-03
NO991838D0 (no) 1999-04-16
EP1795528A1 (en) 2007-06-13
CA2597799A1 (en) 1999-02-25
NZ335156A (en) 2001-10-26
EP0956284A4 (en) 2001-12-05
NO325139B1 (no) 2008-02-11
PL332723A1 (en) 1999-10-11
EP1671960A2 (en) 2006-06-21
ZA987394B (en) 1999-05-14
EP1170292B1 (en) 2007-04-25
IL184321A0 (en) 2007-10-31
IL129386A0 (en) 2000-02-17
EP1170292A2 (en) 2002-01-09
ATE341540T1 (de) 2006-10-15
AU9021198A (en) 1999-03-08
US7288665B1 (en) 2007-10-30
CN1239476A (zh) 1999-12-22
DE69834584T2 (de) 2006-11-23
NO20054512L (no) 1999-06-18
ID21654A (id) 1999-07-08
EP0956284A1 (en) 1999-11-17
ES2286073T3 (es) 2007-12-01
ATE326455T1 (de) 2006-06-15
DE69837684T2 (de) 2007-09-06
PT956284E (pt) 2006-12-29
NO20054513L (no) 1999-06-18
CN1205196C (zh) 2005-06-08
NO991838L (no) 1999-06-18
ATE360624T1 (de) 2007-05-15
BR9806145A (pt) 2000-01-18
DE69836072D1 (de) 2006-11-16
DE69837684D1 (de) 2007-06-06
PL201641B1 (pl) 2009-04-30
EP0956284B1 (en) 2006-10-04
CA2268662A1 (en) 1999-02-25
HUP0300425A2 (hu) 2003-09-29
ES2274579T3 (es) 2007-05-16
EP1170293A3 (en) 2002-04-03
CN1690053A (zh) 2005-11-02
NO20054514L (no) 1999-06-18
DK0956284T3 (da) 2007-02-12
CN1974563A (zh) 2007-06-06
US6191287B1 (en) 2001-02-20
DK1170293T3 (da) 2006-09-11
CZ296580B6 (cs) 2006-04-12
EP1170293B1 (en) 2006-05-17
DE69834584D1 (de) 2006-06-22
JP2001504864A (ja) 2001-04-10
PT1170293E (pt) 2006-07-31
US20050272944A1 (en) 2005-12-08
PL193674B1 (pl) 2007-03-30
EP1170293A2 (en) 2002-01-09
RU2225402C2 (ru) 2004-03-10
PT1170292E (pt) 2007-05-31
CN100351246C (zh) 2007-11-28
HUP0300425A3 (en) 2005-12-28
CY1105399T1 (el) 2010-04-28
US6291691B1 (en) 2001-09-18
EP1193262A1 (en) 2002-04-03
AU744987B2 (en) 2002-03-07
ES2259646T3 (es) 2006-10-16
IL184320A0 (en) 2007-10-31
KR100596989B1 (ko) 2006-07-07
WO1999009021A1 (en) 1999-02-25
US6706896B1 (en) 2004-03-16
CZ133299A3 (cs) 1999-11-17
DK1170292T3 (da) 2007-08-27
DE69836072T2 (de) 2007-01-11
KR20000068782A (ko) 2000-11-25

Similar Documents

Publication Publication Date Title
IL184320A0 (en) Process for selective derivatization of taxanes
TR199900191T2 (xx) (S)-3,4-Dihidroksibutirik asitin korumal� esterlerinin sentezi i�in geli�tirilmi� proses.
BR9605013A (pt) Composiçao de revestimento curável incluindo composto tendo funcionalidade carbamato e hidroxila
ATE180488T1 (de) Synthese von 4-alkoxy-n-acetylneuraminsäure
MA22932A1 (fr) Procede de preparation de compositions detergentes de densite apparente elevee et composition obtenue par ce procede.
ES522637A0 (es) Procedimiento para la preparacion de nuevas sustancias ws 6049.
NO974266L (no) 10-deacetylbaccatin III- og 10-deacetyl-14<beta>-hydroksybaccatin III-derivater, fremgangsmåte ved deres fremstilling og farmasöytiske blandinger som inneholder dem
IT1261489B (it) Procedimento per la produzione di r amminocarnitina e s amminocarnitina.
BR9916648A (pt) Processo para preparar ésteres glioxìlicos ou seus hidratos
JPS5424827A (en) Preparation of carbonate ester
KR920021571A (ko) 3'및/또는 4'oh기에서 엘사마이신 a의 화학적 변형
EP0124252A3 (en) Double ester of 16beta-ethylestran-17beta-ol derivatives
KR850003730A (ko) 항생물질 x-14889 a, b, c 및 d의 제조방법
JPS51138650A (en) Process for preparing optically active trans-cyclopentene-3,5,-diolmon oester
JPS5233353A (en) Starch containing waste solution treatment method
DE69600686D1 (de) Verfahren zur herstellung von butanonderivaten
JPS54154753A (en) Tetrahydroesterastin and its preparation
JPS5444679A (en) Production of 5-acyluridine derivative
JPS649911A (en) Hair cosmetic
JPS57146797A (en) Novel oligomannoside and its preparation
JPS53129441A (en) Aeration method
JPS5398919A (en) Preparation of glucosides
JPS51135894A (en) Process for producing solica-titania catalyst
IT8718703A0 (it) Processo per l'utilizzazione di materiali vegetali di scarto mediante fermentazioni aerobiche controllate precedute da pretrattamenti chimici
JPS572282A (en) Synthesis of fortimicins