JPS572282A - Synthesis of fortimicins - Google Patents

Synthesis of fortimicins

Info

Publication number
JPS572282A
JPS572282A JP7516180A JP7516180A JPS572282A JP S572282 A JPS572282 A JP S572282A JP 7516180 A JP7516180 A JP 7516180A JP 7516180 A JP7516180 A JP 7516180A JP S572282 A JPS572282 A JP S572282A
Authority
JP
Japan
Prior art keywords
formula
compound
derivative
fortamine
purpurosamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP7516180A
Other languages
Japanese (ja)
Other versions
JPS6019918B2 (en
Inventor
Tetsuo Suami
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP55075161A priority Critical patent/JPS6019918B2/en
Publication of JPS572282A publication Critical patent/JPS572282A/en
Publication of JPS6019918B2 publication Critical patent/JPS6019918B2/en
Expired legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Saccharide Compounds (AREA)

Abstract

PURPOSE: The condensation reaction between a purpurosamine saccharide and a fortamine derivative is conducted in the presence of catalyst in a dry atmosphere, then the protecting groups are removed to produce a fortimicin used as an aminoglycoside antibiotic or its synthetic intermediate.
CONSTITUTION: After condensation reaction between a compound of formula I (R1, R2 are H, methyl; R, R6 are protecting group; X is halogen) and another compound of formula II (R3, R4 are H, protected amino group; R5 is H, protected hydroxyl) in the presence of a catalyst under anhydrous conditions, the protecting groups are removed to give a compound of formula III (R3', R4' are H, NH2; R5' is H, hydroxyl). Fortimicin B or sporaricin B are obtained from the compound of formula IV (R is 2,4-dinitrophenyl) and another compound of formula V or 2-deoxy-1-epi- fortamine and sannamycin B is synthesized from a 6-N-methyl-purpurosamine C derivative and a 2-deoxyfortamine B derivative.
COPYRIGHT: (C)1982,JPO&Japio
JP55075161A 1980-06-04 1980-06-04 Synthesis method of fortemisins Expired JPS6019918B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP55075161A JPS6019918B2 (en) 1980-06-04 1980-06-04 Synthesis method of fortemisins

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55075161A JPS6019918B2 (en) 1980-06-04 1980-06-04 Synthesis method of fortemisins

Publications (2)

Publication Number Publication Date
JPS572282A true JPS572282A (en) 1982-01-07
JPS6019918B2 JPS6019918B2 (en) 1985-05-18

Family

ID=13568195

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55075161A Expired JPS6019918B2 (en) 1980-06-04 1980-06-04 Synthesis method of fortemisins

Country Status (1)

Country Link
JP (1) JPS6019918B2 (en)

Also Published As

Publication number Publication date
JPS6019918B2 (en) 1985-05-18

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