JPS57106696A - 1-(beta-d-arabinofuranosyl)cytosine derivative and its preparation - Google Patents

1-(beta-d-arabinofuranosyl)cytosine derivative and its preparation

Info

Publication number
JPS57106696A
JPS57106696A JP55182777A JP18277780A JPS57106696A JP S57106696 A JPS57106696 A JP S57106696A JP 55182777 A JP55182777 A JP 55182777A JP 18277780 A JP18277780 A JP 18277780A JP S57106696 A JPS57106696 A JP S57106696A
Authority
JP
Japan
Prior art keywords
arabinofuranosyl
amino
protecting group
cytosine
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP55182777A
Other languages
Japanese (ja)
Other versions
JPS636080B2 (en
Inventor
Yoshinori Kato
Hisashi Fukushima
Takeshi Hara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP55182777A priority Critical patent/JPS57106696A/en
Publication of JPS57106696A publication Critical patent/JPS57106696A/en
Publication of JPS636080B2 publication Critical patent/JPS636080B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The compound of formulaI(R1 is H or 1W4C alkyl; R2 is 2W 20C bivalent aliphatic hydrocarbon group; R3 is H or alkali cation).
EXAMPLE: 1-[5'-(2-Aminoethylphosphoryl)-β-D-arabinofuranosyl]cytosine.
USE: An antitumor agent. It can be administered orally, and exhibits excellent activity. It is also useful as an intermediate for the synthesis of pharmaceuticals.
PROCESS: The compound of formulaIis prepared by reacting the protected 1-(β- D-arabinofuranosyl)cytosine 5'-phosphate of formula II (R4 is amino-protecting group; R5 and R6 are same or different OH-protecting group) with the amino- protected amino alcohol of formula III (R7 is amino-protecting group) to form phosphodiester bond, removing the protecting groups R4, R5, R6 and R7 from the product, and if necessary, converting the product to an alkali salt.
COPYRIGHT: (C)1982,JPO&Japio
JP55182777A 1980-12-25 1980-12-25 1-(beta-d-arabinofuranosyl)cytosine derivative and its preparation Granted JPS57106696A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP55182777A JPS57106696A (en) 1980-12-25 1980-12-25 1-(beta-d-arabinofuranosyl)cytosine derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55182777A JPS57106696A (en) 1980-12-25 1980-12-25 1-(beta-d-arabinofuranosyl)cytosine derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS57106696A true JPS57106696A (en) 1982-07-02
JPS636080B2 JPS636080B2 (en) 1988-02-08

Family

ID=16124227

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55182777A Granted JPS57106696A (en) 1980-12-25 1980-12-25 1-(beta-d-arabinofuranosyl)cytosine derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS57106696A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5993100A (en) * 1983-10-31 1984-05-29 Wakunaga Seiyaku Kk Oligonucleotide derivative and its preparation
JPS6191196A (en) * 1984-10-09 1986-05-09 Toyama Chem Co Ltd Novel 5-fluoro-2'-deoxyuridine 5'-phosphate derivative and its salt
WO2003016423A1 (en) * 2001-08-20 2003-02-27 Japan Science And Technology Corporation Hydrogelation agents
US7196178B2 (en) 2001-08-07 2007-03-27 Japan Science And Technology Agency Sugar-derived gellant for hydrogel formation

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5993100A (en) * 1983-10-31 1984-05-29 Wakunaga Seiyaku Kk Oligonucleotide derivative and its preparation
JPH0374239B2 (en) * 1983-10-31 1991-11-26
JPS6191196A (en) * 1984-10-09 1986-05-09 Toyama Chem Co Ltd Novel 5-fluoro-2'-deoxyuridine 5'-phosphate derivative and its salt
JPH0153879B2 (en) * 1984-10-09 1989-11-15 Toyama Chemical Co Ltd
US7196178B2 (en) 2001-08-07 2007-03-27 Japan Science And Technology Agency Sugar-derived gellant for hydrogel formation
WO2003016423A1 (en) * 2001-08-20 2003-02-27 Japan Science And Technology Corporation Hydrogelation agents

Also Published As

Publication number Publication date
JPS636080B2 (en) 1988-02-08

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