JPS57146798A - Hexosyl nucleoside derivative - Google Patents

Hexosyl nucleoside derivative

Info

Publication number
JPS57146798A
JPS57146798A JP56032729A JP3272981A JPS57146798A JP S57146798 A JPS57146798 A JP S57146798A JP 56032729 A JP56032729 A JP 56032729A JP 3272981 A JP3272981 A JP 3272981A JP S57146798 A JPS57146798 A JP S57146798A
Authority
JP
Japan
Prior art keywords
derivative
group
cho
hexosyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56032729A
Other languages
Japanese (ja)
Inventor
Toru Ueda
Hideo Inoue
Satoshi Shuto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamasa Shoyu KK
Original Assignee
Yamasa Shoyu KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamasa Shoyu KK filed Critical Yamasa Shoyu KK
Priority to JP56032729A priority Critical patent/JPS57146798A/en
Publication of JPS57146798A publication Critical patent/JPS57146798A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

NEW MATERIAL:The hexosyl nucleoside derivative of formulaI(B is nucleic acid base; R1 is H, provided that when R2 is H, then R1 is NO2, NH2, CHO or CH2OH; R2 is H, provided that when R1 is H, R2 is CHO or CH2OH; when R1 is NO2 or NH2, then R3 is group of formula II, and when R1 or R2 is CHO or CH2OH, R3 is group of formula III), and its protected compound.
EXAMPLE: 2',3'-Dideoxy-3'-(S)-hydroxymethyluridine.
USE: 2'-Deoxynucleoside antagonist (nucleic acid metabolism inhibiting agent, enzymatic reaction inhibiting agent, antitumor agent, antiviral agent, etc.).
PROCESS: For example, the 4- and 6-positions of 3'-deoxy-3'-nitro-β-D-glucopyranosyluracil are protected with benzaldehyde, and the protecting groups are removed after converting the compound to 2,3-dideoxy derivative. The nitro group of the product is reduced to amino group, and diazotized. The product is converted to 3'-formyl derivative and then intramolecular hemiacetal derivative, and reduced with NaBH4 to obtain the exemplified compound.
COPYRIGHT: (C)1982,JPO&Japio
JP56032729A 1981-03-06 1981-03-06 Hexosyl nucleoside derivative Pending JPS57146798A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56032729A JPS57146798A (en) 1981-03-06 1981-03-06 Hexosyl nucleoside derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56032729A JPS57146798A (en) 1981-03-06 1981-03-06 Hexosyl nucleoside derivative

Publications (1)

Publication Number Publication Date
JPS57146798A true JPS57146798A (en) 1982-09-10

Family

ID=12366924

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56032729A Pending JPS57146798A (en) 1981-03-06 1981-03-06 Hexosyl nucleoside derivative

Country Status (1)

Country Link
JP (1) JPS57146798A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145960A (en) * 1989-04-24 1992-09-08 E. R. Squibb & Sons, Inc. Pyrimidinyl tetrahydrofurans
US5164520A (en) * 1989-04-24 1992-11-17 E. R. Squibb & Sons, Inc. Intermediates for purinyl and pyrimidinyl tetrahydrofurans
US5215970A (en) * 1987-04-16 1993-06-01 Medivir Ab Nucleosides and nucleotide analogues, pharmaceutical composition and processes for the preparation of the compounds
US5272152A (en) * 1990-07-02 1993-12-21 E. R. Squibb & Sons, Inc. Purinyl and pyrimidinyl tetrahydrofurans
US5473063A (en) * 1990-10-02 1995-12-05 Medivir Ab Synthesis of furanosyl compounds useful as intermediates in preparation of nucleoside analogues
US6576763B1 (en) 1996-02-16 2003-06-10 Medivir Ab Acyclic nucleoside derivatives

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5215970A (en) * 1987-04-16 1993-06-01 Medivir Ab Nucleosides and nucleotide analogues, pharmaceutical composition and processes for the preparation of the compounds
US5409906A (en) * 1987-04-16 1995-04-25 Medivir Ab α nucleoside compounds and a method for treating HBV using said compounds
US5145960A (en) * 1989-04-24 1992-09-08 E. R. Squibb & Sons, Inc. Pyrimidinyl tetrahydrofurans
US5164520A (en) * 1989-04-24 1992-11-17 E. R. Squibb & Sons, Inc. Intermediates for purinyl and pyrimidinyl tetrahydrofurans
US5272152A (en) * 1990-07-02 1993-12-21 E. R. Squibb & Sons, Inc. Purinyl and pyrimidinyl tetrahydrofurans
US5473063A (en) * 1990-10-02 1995-12-05 Medivir Ab Synthesis of furanosyl compounds useful as intermediates in preparation of nucleoside analogues
US5747473A (en) * 1990-10-02 1998-05-05 Medivir Ab L-nucleoside analogues and pharmaceutical compositions
US5952500A (en) * 1990-10-02 1999-09-14 Medivir Ab Nucleoside derivatives
US6121431A (en) * 1990-10-02 2000-09-19 Medivir Ab Nucleoside derivatives
US6576763B1 (en) 1996-02-16 2003-06-10 Medivir Ab Acyclic nucleoside derivatives

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