JPS5634697A - Preparation of 5'-triphosphoryladnylyl-(2'-5')-adenylyl-(2'-5')-adenosine - Google Patents

Preparation of 5'-triphosphoryladnylyl-(2'-5')-adenylyl-(2'-5')-adenosine

Info

Publication number
JPS5634697A
JPS5634697A JP11152479A JP11152479A JPS5634697A JP S5634697 A JPS5634697 A JP S5634697A JP 11152479 A JP11152479 A JP 11152479A JP 11152479 A JP11152479 A JP 11152479A JP S5634697 A JPS5634697 A JP S5634697A
Authority
JP
Japan
Prior art keywords
group
oligomer
formula
adenosine
triphosphate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11152479A
Other languages
Japanese (ja)
Other versions
JPS6121560B2 (en
Inventor
Morio Ikehara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WAKINAGA YAKUHIN KK
Wakunaga Pharmaceutical Co Ltd
Original Assignee
WAKINAGA YAKUHIN KK
Wakunaga Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WAKINAGA YAKUHIN KK, Wakunaga Pharmaceutical Co Ltd filed Critical WAKINAGA YAKUHIN KK
Priority to JP11152479A priority Critical patent/JPS5634697A/en
Publication of JPS5634697A publication Critical patent/JPS5634697A/en
Publication of JPS6121560B2 publication Critical patent/JPS6121560B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Saccharide Compounds (AREA)

Abstract

PURPOSE: To prepare the titled compound having protein-synthesis inhibiting activity and useful as a carcinostatic agent, etc., by the total synthesis which comprises the conversion of the (2'-5')oligomer of adenosine-5'-monophosphate having a 3'-OH group protected with a specific group to 5'-triphosphate, and the elimination of the protecting group from the product.
CONSTITUTION: The objective compound of formula III (A is adenylyl) is prepared by (1) converting the (2'-5')oligomer of the adenosine-5'-mono-phosphate of formula II (NB is o-nitrobenzyl; n is 0, 1 or 2) to the 5'-triphosphate, and (2) eliminating the protecting group of the 3'-OH group. The oligomer of formula II can be prepared by converting the 3'-OH group of a compound of formula I (X is acyl or substituted or unsubstituted trityl) to o-nitro-4- and/or 5-substituted or unsubstituted benzyl group. The conversion to 5'-triphosphate is preferably carried out by reacting the oligomer with 1,1'-carbonylimidazole, and treating the reaction product with pyrophosphoric acid salt. The elimination of the protecting group is carried out preferably by the irradiation with ultraviolet rays having wavelength of ≥ 280nm.
COPYRIGHT: (C)1981,JPO&Japio
JP11152479A 1979-08-31 1979-08-31 Preparation of 5'-triphosphoryladnylyl-(2'-5')-adenylyl-(2'-5')-adenosine Granted JPS5634697A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11152479A JPS5634697A (en) 1979-08-31 1979-08-31 Preparation of 5'-triphosphoryladnylyl-(2'-5')-adenylyl-(2'-5')-adenosine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11152479A JPS5634697A (en) 1979-08-31 1979-08-31 Preparation of 5'-triphosphoryladnylyl-(2'-5')-adenylyl-(2'-5')-adenosine

Publications (2)

Publication Number Publication Date
JPS5634697A true JPS5634697A (en) 1981-04-06
JPS6121560B2 JPS6121560B2 (en) 1986-05-27

Family

ID=14563508

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11152479A Granted JPS5634697A (en) 1979-08-31 1979-08-31 Preparation of 5'-triphosphoryladnylyl-(2'-5')-adenylyl-(2'-5')-adenosine

Country Status (1)

Country Link
JP (1) JPS5634697A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63226405A (en) * 1987-03-16 1988-09-21 Yasunobu Tomoto Artificial ground structure for soft ground
US4880918A (en) * 1982-07-13 1989-11-14 Eliezer Rapaport Arrest and killing of tumor cells by adenosine 5-diphosphate and adenosine-5-triphosphate
US5049372A (en) * 1982-07-13 1991-09-17 Eliezer Rapaport Anticancer activities in a host by increasing blood and plasma adenosine 5'-triphosphate (ATP) levels
US5227371A (en) * 1982-07-13 1993-07-13 Eliezer Rapaport Utilization of adenine nucleotides and/or adenosine and inorganic phosphate for elevation of liver, blood and blood plasma adenosine 5'-triphosphate concentrations

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEM. PHARM. BULL.=1977 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880918A (en) * 1982-07-13 1989-11-14 Eliezer Rapaport Arrest and killing of tumor cells by adenosine 5-diphosphate and adenosine-5-triphosphate
US5049372A (en) * 1982-07-13 1991-09-17 Eliezer Rapaport Anticancer activities in a host by increasing blood and plasma adenosine 5'-triphosphate (ATP) levels
US5227371A (en) * 1982-07-13 1993-07-13 Eliezer Rapaport Utilization of adenine nucleotides and/or adenosine and inorganic phosphate for elevation of liver, blood and blood plasma adenosine 5'-triphosphate concentrations
JPS63226405A (en) * 1987-03-16 1988-09-21 Yasunobu Tomoto Artificial ground structure for soft ground

Also Published As

Publication number Publication date
JPS6121560B2 (en) 1986-05-27

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