JPS5634696A - Preparation of n6-acyl or trityl-3'-0(o-nitro-benzyl) adenosine - Google Patents
Preparation of n6-acyl or trityl-3'-0(o-nitro-benzyl) adenosineInfo
- Publication number
- JPS5634696A JPS5634696A JP11152179A JP11152179A JPS5634696A JP S5634696 A JPS5634696 A JP S5634696A JP 11152179 A JP11152179 A JP 11152179A JP 11152179 A JP11152179 A JP 11152179A JP S5634696 A JPS5634696 A JP S5634696A
- Authority
- JP
- Japan
- Prior art keywords
- acyl
- adenosine
- group
- substituted
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Saccharide Compounds (AREA)
Abstract
PURPOSE: To prepare the titled compound useful as an intermediate for the total synthesis of a carcinostatic agent, by reacting an N6-acyl or trityladenosine with an o-nitrophenyl diazomethane under the conditions to proceed the benzylation prefrentially at the 3'-OH group.
CONSTITUTION: An N6-acyl or substituted or unsubstituted trityladenosine is prepared by protecting the 6-position amino group of adenosine with acyl or substituted or unsubstituted trityl group. The product is made to react with a 4- and/or 5-substituted or unsubstituted o-nitrophenyl diazomethane or o-nitrobenzyl halogenide under the conditions to proceed the benzylation preferentially at the 3'-OH group. The objective compound which is an intermediate of 5'-triphosphoryladenylyl-(2'-5')-adenylyl-(2'-5')adenosine having protein-synthesis inhibiting activity is prepared by this process.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11152179A JPS5634696A (en) | 1979-08-31 | 1979-08-31 | Preparation of n6-acyl or trityl-3'-0(o-nitro-benzyl) adenosine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11152179A JPS5634696A (en) | 1979-08-31 | 1979-08-31 | Preparation of n6-acyl or trityl-3'-0(o-nitro-benzyl) adenosine |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5634696A true JPS5634696A (en) | 1981-04-06 |
JPS6118558B2 JPS6118558B2 (en) | 1986-05-13 |
Family
ID=14563427
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11152179A Granted JPS5634696A (en) | 1979-08-31 | 1979-08-31 | Preparation of n6-acyl or trityl-3'-0(o-nitro-benzyl) adenosine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5634696A (en) |
-
1979
- 1979-08-31 JP JP11152179A patent/JPS5634696A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6118558B2 (en) | 1986-05-13 |
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