JPS5634696A - Preparation of n6-acyl or trityl-3'-0(o-nitro-benzyl) adenosine - Google Patents

Preparation of n6-acyl or trityl-3'-0(o-nitro-benzyl) adenosine

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Publication number
JPS5634696A
JPS5634696A JP11152179A JP11152179A JPS5634696A JP S5634696 A JPS5634696 A JP S5634696A JP 11152179 A JP11152179 A JP 11152179A JP 11152179 A JP11152179 A JP 11152179A JP S5634696 A JPS5634696 A JP S5634696A
Authority
JP
Japan
Prior art keywords
acyl
adenosine
group
substituted
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11152179A
Other languages
Japanese (ja)
Other versions
JPS6118558B2 (en
Inventor
Morio Ikehara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WAKINAGA YAKUHIN KK
Wakunaga Pharmaceutical Co Ltd
Original Assignee
WAKINAGA YAKUHIN KK
Wakunaga Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WAKINAGA YAKUHIN KK, Wakunaga Pharmaceutical Co Ltd filed Critical WAKINAGA YAKUHIN KK
Priority to JP11152179A priority Critical patent/JPS5634696A/en
Publication of JPS5634696A publication Critical patent/JPS5634696A/en
Publication of JPS6118558B2 publication Critical patent/JPS6118558B2/ja
Granted legal-status Critical Current

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Abstract

PURPOSE: To prepare the titled compound useful as an intermediate for the total synthesis of a carcinostatic agent, by reacting an N6-acyl or trityladenosine with an o-nitrophenyl diazomethane under the conditions to proceed the benzylation prefrentially at the 3'-OH group.
CONSTITUTION: An N6-acyl or substituted or unsubstituted trityladenosine is prepared by protecting the 6-position amino group of adenosine with acyl or substituted or unsubstituted trityl group. The product is made to react with a 4- and/or 5-substituted or unsubstituted o-nitrophenyl diazomethane or o-nitrobenzyl halogenide under the conditions to proceed the benzylation preferentially at the 3'-OH group. The objective compound which is an intermediate of 5'-triphosphoryladenylyl-(2'-5')-adenylyl-(2'-5')adenosine having protein-synthesis inhibiting activity is prepared by this process.
COPYRIGHT: (C)1981,JPO&Japio
JP11152179A 1979-08-31 1979-08-31 Preparation of n6-acyl or trityl-3'-0(o-nitro-benzyl) adenosine Granted JPS5634696A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11152179A JPS5634696A (en) 1979-08-31 1979-08-31 Preparation of n6-acyl or trityl-3'-0(o-nitro-benzyl) adenosine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11152179A JPS5634696A (en) 1979-08-31 1979-08-31 Preparation of n6-acyl or trityl-3'-0(o-nitro-benzyl) adenosine

Publications (2)

Publication Number Publication Date
JPS5634696A true JPS5634696A (en) 1981-04-06
JPS6118558B2 JPS6118558B2 (en) 1986-05-13

Family

ID=14563427

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11152179A Granted JPS5634696A (en) 1979-08-31 1979-08-31 Preparation of n6-acyl or trityl-3'-0(o-nitro-benzyl) adenosine

Country Status (1)

Country Link
JP (1) JPS5634696A (en)

Also Published As

Publication number Publication date
JPS6118558B2 (en) 1986-05-13

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