JPS57167941A - Purification of clinofibrate - Google Patents
Purification of clinofibrateInfo
- Publication number
- JPS57167941A JPS57167941A JP5405781A JP5405781A JPS57167941A JP S57167941 A JPS57167941 A JP S57167941A JP 5405781 A JP5405781 A JP 5405781A JP 5405781 A JP5405781 A JP 5405781A JP S57167941 A JPS57167941 A JP S57167941A
- Authority
- JP
- Japan
- Prior art keywords
- clinofibrate
- acid
- ammonium salt
- precipitated
- ammonia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To prepare high purity clinofibrate, in high yield, by reacting crude clinofibrate with ammonia in acetone or methyl ethyl ketone, separating the precipitated clinofibrate ammonium salt, and treating with an acid.
CONSTITUTION: Crude clinofibrate of formula[2,2'-(4,4'-cyclohexylidenediphenoxy)-2,2'-dimethyl-dibutyric acid]is made to react with ammonia in acetone or methyl ethyl ketone, and the precipitated clinofibrate ammonium salt, is separated and treated with an acid to obtain the objective clinofibrate. The loss of clinofibrate is small because the separation of the clinofibrate ammonium salt from the ammonium salt of the by-produced carboxylic acids (e.g. 2,3-dimethylacrylic acid, 2-methylacrylic acid, etc.) can be carried out almost perfectly.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5405781A JPS57167941A (en) | 1981-04-09 | 1981-04-09 | Purification of clinofibrate |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5405781A JPS57167941A (en) | 1981-04-09 | 1981-04-09 | Purification of clinofibrate |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57167941A true JPS57167941A (en) | 1982-10-16 |
JPS6213936B2 JPS6213936B2 (en) | 1987-03-30 |
Family
ID=12959979
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5405781A Granted JPS57167941A (en) | 1981-04-09 | 1981-04-09 | Purification of clinofibrate |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57167941A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102816060A (en) * | 2012-09-14 | 2012-12-12 | 瑞阳制药有限公司 | Preparation method of high-purity clinofibrate |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH022320U (en) * | 1988-06-13 | 1990-01-09 |
-
1981
- 1981-04-09 JP JP5405781A patent/JPS57167941A/en active Granted
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102816060A (en) * | 2012-09-14 | 2012-12-12 | 瑞阳制药有限公司 | Preparation method of high-purity clinofibrate |
Also Published As
Publication number | Publication date |
---|---|
JPS6213936B2 (en) | 1987-03-30 |
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