Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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AGC Inc
Original Assignee
Asahi Glass Co Ltd
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Filing date
Publication date
Application filed by Asahi Glass Co LtdfiledCriticalAsahi Glass Co Ltd
Priority to JP17723187ApriorityCriticalpatent/JPS6422894A/en
Publication of JPS6422894ApublicationCriticalpatent/JPS6422894A/en
NEW MATERIAL:2',3-Deoxy-2',3'-didehydro-3'-fluoronucleosides expressed by the formula (B is residue of nucleic acid bases). EXAMPLE:2',3'-Dideoxy-2',3'-didehydro-3'-fluoroadenosine. USE:An antitumor and antiviral agents. PREPARATION:The hydroxy group at the 5-position of a 3'-deoxy-3'- fluoropentofuranoside derivative and, as necessary, amino group there are initially protected and the resultant compound is then treated with a base, such as sodium hydroxide, and successively reacted with carbon disulfide and methyl iodide to provide methyl xanthate, which is subsequently subjected to dehydrogenation reaction by heating at 100-250 deg.C.