KR860001866B1 - Process for preparing 2'-deoxy-5-substituted uridine derivatives - Google Patents
Process for preparing 2'-deoxy-5-substituted uridine derivativesInfo
- Publication number
- KR860001866B1 KR860001866B1 KR8607840A KR860007840A KR860001866B1 KR 860001866 B1 KR860001866 B1 KR 860001866B1 KR 8607840 A KR8607840 A KR 8607840A KR 860007840 A KR860007840 A KR 860007840A KR 860001866 B1 KR860001866 B1 KR 860001866B1
- Authority
- KR
- South Korea
- Prior art keywords
- deoxy
- alpha
- uridine
- trifluoromethyl
- preparing
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
2'-Deoxy-5-substd. uridine derivs. (I) [R1=H, benzoyl, tetrahydrofuranyl; R2=F, trifluoromethyl; R3,R4=The one is H, the other is alkyl, alkenyl or benzyl group! are prepd. for use as a medicine for a tumor. 1 g of 2'-deoxy-5-trifluoromethyl uridine is dissolved into 15 ml of 1,4-dioxane, and 2.50 g of bis-(alpha, alpha- dimethylbenzyloxy)methane and 38 mg of anhydrous toluene sulfonic acid are added into the soln.. This mixt. is stirred for 3.5 hrs. at 60≰C, and then distilled. The residues are seperated by silicagel column chromato graphy to give 0.40g of 2'-deoxy-5'0-(alpha, alpha- dimethylbenzyl)-5-trifluoromethyl uridine and 0.28g of 2'-deoxy-3'-0- (alpha, alpha-dimethylbenzyl)-5-trifluoromethyl uridine.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR8607840A KR860001866B1 (en) | 1983-05-23 | 1986-09-17 | Process for preparing 2'-deoxy-5-substituted uridine derivatives |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP58091190A JPS59216899A (en) | 1983-05-23 | 1983-05-23 | 2'-deoxy-5-trifluoromethyluridine derivative, its preparation, and antitumor agent containing it |
JP58170149A JPS6061593A (en) | 1983-09-14 | 1983-09-14 | 2'-deoxy-5-trifluoromethyluridine derivative and antitumor agent containing the same |
JP58170147A JPS6061591A (en) | 1983-09-14 | 1983-09-14 | 2'-deoxy-5-fluorouridine derivative, its preparation and antitumor agent containing the same |
KR1019840002789A KR860001865B1 (en) | 1983-05-23 | 1984-05-22 | Process for preparing 2'-deoxy-5-substituted uridine derivatives |
KR8607840A KR860001866B1 (en) | 1983-05-23 | 1986-09-17 | Process for preparing 2'-deoxy-5-substituted uridine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
KR860001866B1 true KR860001866B1 (en) | 1986-10-24 |
Family
ID=27525532
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR8607840A KR860001866B1 (en) | 1983-05-23 | 1986-09-17 | Process for preparing 2'-deoxy-5-substituted uridine derivatives |
Country Status (1)
Country | Link |
---|---|
KR (1) | KR860001866B1 (en) |
-
1986
- 1986-09-17 KR KR8607840A patent/KR860001866B1/en not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A107 | Divisional application of patent | ||
A201 | Request for examination | ||
G160 | Decision to publish patent application | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 19871224 Year of fee payment: 12 |
|
LAPS | Lapse due to unpaid annual fee |