JPS57114516A - Inhibitor of phosphodiesterase reaction - Google Patents

Inhibitor of phosphodiesterase reaction

Info

Publication number
JPS57114516A
JPS57114516A JP11746781A JP11746781A JPS57114516A JP S57114516 A JPS57114516 A JP S57114516A JP 11746781 A JP11746781 A JP 11746781A JP 11746781 A JP11746781 A JP 11746781A JP S57114516 A JPS57114516 A JP S57114516A
Authority
JP
Japan
Prior art keywords
inhibitor
adenosine
formula
compound shown
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11746781A
Other languages
Japanese (ja)
Other versions
JPS6122954B2 (en
Inventor
Yukinae Yamazaki
Hideo Suzuki
Akira Kamibayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Institute of Advanced Industrial Science and Technology AIST
Original Assignee
Agency of Industrial Science and Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency of Industrial Science and Technology filed Critical Agency of Industrial Science and Technology
Priority to JP11746781A priority Critical patent/JPS57114516A/en
Publication of JPS57114516A publication Critical patent/JPS57114516A/en
Publication of JPS6122954B2 publication Critical patent/JPS6122954B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound shown by the formula[R is lower alkyl which may have a substituent group (carboxyl, or amino), aryl].
EXAMPLE: 6-[(1-Methylethyl)thiomethylamino]-9-β-D-ribofuranosylpurine.
USE: An inhibitor of enzyme reaction. By adding the inhibitor to the enzyme reaction, the activity of phosphodiesterase is inhibited, and the decomposition of cyclic AMP is protected.
PROCESS: Adenosine is reacted with a compound shown by the formula HS-R(R is methyl, ethyl, propyl, isopropyl, butyl, etc.) and formaldehyde in water, to give a compound shown by the formula. A substituent group is easily introduced to the N6-NH2 group of adenosine, the reaction time is usually ≤15 hours, and this process is advantageous. A particular pretreatment, for example, the protection of OH in the ribose group of adenosine, etc. is unnecessary, and the process is advantageous.
COPYRIGHT: (C)1982,JPO&Japio
JP11746781A 1981-07-27 1981-07-27 Inhibitor of phosphodiesterase reaction Granted JPS57114516A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP11746781A JPS57114516A (en) 1981-07-27 1981-07-27 Inhibitor of phosphodiesterase reaction

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11746781A JPS57114516A (en) 1981-07-27 1981-07-27 Inhibitor of phosphodiesterase reaction

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP16496678A Division JPS5589296A (en) 1978-12-27 1978-12-27 Novel adenosine derivative having dhysiological activity

Publications (2)

Publication Number Publication Date
JPS57114516A true JPS57114516A (en) 1982-07-16
JPS6122954B2 JPS6122954B2 (en) 1986-06-03

Family

ID=14712400

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11746781A Granted JPS57114516A (en) 1981-07-27 1981-07-27 Inhibitor of phosphodiesterase reaction

Country Status (1)

Country Link
JP (1) JPS57114516A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5498605A (en) * 1992-07-15 1996-03-12 The United States Of America As Represented By The Department Of Health And Human Services Sulfo-derivatives of adenosine
WO2004050678A3 (en) * 2002-12-03 2004-08-19 Univ Baylor Compounds resistant to metabolic deactivation and methods of use

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5498605A (en) * 1992-07-15 1996-03-12 The United States Of America As Represented By The Department Of Health And Human Services Sulfo-derivatives of adenosine
WO2004050678A3 (en) * 2002-12-03 2004-08-19 Univ Baylor Compounds resistant to metabolic deactivation and methods of use
JP2006510633A (en) * 2002-12-03 2006-03-30 ベイラー ユニバーシティー Compounds resistant to metabolic inactivation and methods of use

Also Published As

Publication number Publication date
JPS6122954B2 (en) 1986-06-03

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