JPS57114516A - Inhibitor of phosphodiesterase reaction - Google Patents
Inhibitor of phosphodiesterase reactionInfo
- Publication number
- JPS57114516A JPS57114516A JP11746781A JP11746781A JPS57114516A JP S57114516 A JPS57114516 A JP S57114516A JP 11746781 A JP11746781 A JP 11746781A JP 11746781 A JP11746781 A JP 11746781A JP S57114516 A JPS57114516 A JP S57114516A
- Authority
- JP
- Japan
- Prior art keywords
- inhibitor
- adenosine
- formula
- compound shown
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:A compound shown by the formula[R is lower alkyl which may have a substituent group (carboxyl, or amino), aryl].
EXAMPLE: 6-[(1-Methylethyl)thiomethylamino]-9-β-D-ribofuranosylpurine.
USE: An inhibitor of enzyme reaction. By adding the inhibitor to the enzyme reaction, the activity of phosphodiesterase is inhibited, and the decomposition of cyclic AMP is protected.
PROCESS: Adenosine is reacted with a compound shown by the formula HS-R(R is methyl, ethyl, propyl, isopropyl, butyl, etc.) and formaldehyde in water, to give a compound shown by the formula. A substituent group is easily introduced to the N6-NH2 group of adenosine, the reaction time is usually ≤15 hours, and this process is advantageous. A particular pretreatment, for example, the protection of OH in the ribose group of adenosine, etc. is unnecessary, and the process is advantageous.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11746781A JPS57114516A (en) | 1981-07-27 | 1981-07-27 | Inhibitor of phosphodiesterase reaction |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11746781A JPS57114516A (en) | 1981-07-27 | 1981-07-27 | Inhibitor of phosphodiesterase reaction |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP16496678A Division JPS5589296A (en) | 1978-12-27 | 1978-12-27 | Novel adenosine derivative having dhysiological activity |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57114516A true JPS57114516A (en) | 1982-07-16 |
JPS6122954B2 JPS6122954B2 (en) | 1986-06-03 |
Family
ID=14712400
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11746781A Granted JPS57114516A (en) | 1981-07-27 | 1981-07-27 | Inhibitor of phosphodiesterase reaction |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57114516A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5498605A (en) * | 1992-07-15 | 1996-03-12 | The United States Of America As Represented By The Department Of Health And Human Services | Sulfo-derivatives of adenosine |
WO2004050678A3 (en) * | 2002-12-03 | 2004-08-19 | Univ Baylor | Compounds resistant to metabolic deactivation and methods of use |
-
1981
- 1981-07-27 JP JP11746781A patent/JPS57114516A/en active Granted
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5498605A (en) * | 1992-07-15 | 1996-03-12 | The United States Of America As Represented By The Department Of Health And Human Services | Sulfo-derivatives of adenosine |
WO2004050678A3 (en) * | 2002-12-03 | 2004-08-19 | Univ Baylor | Compounds resistant to metabolic deactivation and methods of use |
JP2006510633A (en) * | 2002-12-03 | 2006-03-30 | ベイラー ユニバーシティー | Compounds resistant to metabolic inactivation and methods of use |
Also Published As
Publication number | Publication date |
---|---|
JPS6122954B2 (en) | 1986-06-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
YU47791B (en) | PROCEDURE FOR OBTAINING DIDEOXYCHIDROCAR-BOCYCLIC NUCLEOSIDES | |
EP0884300A4 (en) | Process for preparing free alpha-hydroxy acids from ammonium salts thereof | |
GB2091723B (en) | Derivatives of 2-oxoazetidine-1-sulphonic acid | |
JPS5791997A (en) | 5'-o-acylnucleoside and its preparation | |
IE41052B1 (en) | Crop protection composition and method of application, whereby the drift of spraying liquids may be reduced | |
ES8704153A1 (en) | Pyrimidine derivatives, processes for preparation thereof and composition of the same. | |
JPS57114516A (en) | Inhibitor of phosphodiesterase reaction | |
JPS57146798A (en) | Hexosyl nucleoside derivative | |
JPS5731696A (en) | Anthracycline derivative | |
ES2092962A1 (en) | Nitric esters of 2-(2,6-dihalophenylamino) phenylacetoxyacetic acid derivatives and their preparation process | |
JPS5334716A (en) | Preparation of amide amine amphoteric surface active agent | |
JPS5748971A (en) | Novel alkylimidazole derivative | |
JPS57123155A (en) | Preparation of pyrrolidine derivative and its intermediate | |
JPS5721400A (en) | Novel fortimicin derivative | |
ATE20742T1 (en) | PROCESS FOR THE PREPARATION OF PYRAZINE DERIVATIVES. | |
CA2206804A1 (en) | Trisubstituted thioxanthines | |
JPS5587721A (en) | Anti-tumor agent | |
EP0636612A4 (en) | Process for producing tetrahydroisoquinoline-3-carboxylic acid derivative. | |
JPS5716892A (en) | Synthesis of n-trialkylsilylmethylurea | |
JPS5718697A (en) | 5-acetonyluracil derivative and its preparation | |
UA10967C2 (en) | 4.5-dimethyl-2-H-propylthio-2-W-H-perfluorbutyl-3H,6H-thiaine 4.5-DIMETHYL-2-H-PROPYLATHIO-2-W-H-PERFLUORBUTYL-3H. 6H-THIAINE AND A PROCESS FOR ITS PREPARATION | |
PL348919A1 (en) | Method for preparing bicyclic compounds and use of said method for preparing an interleukin-1$g(b) conversion enzyme (ice) inhibitor | |
JPS57192341A (en) | Isoprenylamine derivative | |
JPS57192348A (en) | Decaprenyl-substituted amino acid derivative | |
JPS574981A (en) | Novel amino glucoside |