IE780841L - Kanamycin derivatives - Google Patents

Kanamycin derivatives

Info

Publication number
IE780841L
IE780841L IE780841A IE84178A IE780841L IE 780841 L IE780841 L IE 780841L IE 780841 A IE780841 A IE 780841A IE 84178 A IE84178 A IE 84178A IE 780841 L IE780841 L IE 780841L
Authority
IE
Ireland
Prior art keywords
amino
formula
image
kanamycin
protective group
Prior art date
Application number
IE780841A
Other versions
IE46945B1 (en
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of IE780841L publication Critical patent/IE780841L/en
Publication of IE46945B1 publication Critical patent/IE46945B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

1-N-[ omega -amino- alpha -hydroxyalkanoyl] kanamycins A and B of the formula I <IMAGE> in which R represents OH or NH2, are prepared by acylation of polysilylated kanamycin A or B, or polysilylated kanamycin A or B which has a protective group other than silyl on the 6'-amino group, with an acylating derivative of an acid of the formula II <IMAGE> in which n is an integer from 0 to 2 and B is an amino protective group, in an essentially anhydrous organic solvent and by subsequent removal of all blocking groups. The compounds have therapeutic properties. [GB1598294A]
IE841/78A 1977-04-28 1978-04-27 Process for the preparation of kanamycin derivatives IE46945B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79180677A 1977-04-28 1977-04-28
US88858578A 1978-03-20 1978-03-20

Publications (2)

Publication Number Publication Date
IE780841L true IE780841L (en) 1978-10-28
IE46945B1 IE46945B1 (en) 1983-11-16

Family

ID=27121201

Family Applications (2)

Application Number Title Priority Date Filing Date
IE842/78A IE47271B1 (en) 1977-04-28 1978-04-27 Process for the preparation of 1-n-acyl-aminoglycosides
IE841/78A IE46945B1 (en) 1977-04-28 1978-04-27 Process for the preparation of kanamycin derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IE842/78A IE47271B1 (en) 1977-04-28 1978-04-27 Process for the preparation of 1-n-acyl-aminoglycosides

Country Status (27)

Country Link
JP (1) JPS53149951A (en)
AR (1) AR218910A1 (en)
AT (1) AT357675B (en)
CA (2) CA1100953A (en)
CH (1) CH639104A5 (en)
CS (1) CS207607B2 (en)
CY (1) CY1241A (en)
DE (2) DE2818992A1 (en)
DK (2) DK172543B1 (en)
EG (1) EG13710A (en)
ES (1) ES469303A1 (en)
FI (1) FI781288A (en)
FR (2) FR2388826A1 (en)
GB (1) GB1598294A (en)
HK (1) HK51484A (en)
IE (2) IE47271B1 (en)
IT (2) IT1105500B (en)
KE (1) KE3398A (en)
LU (1) LU79541A1 (en)
MY (1) MY8500528A (en)
NL (1) NL178790C (en)
NO (2) NO149635C (en)
PL (1) PL117307B1 (en)
PT (1) PT67959B (en)
SE (2) SE447259B (en)
SG (1) SG22884G (en)
YU (2) YU41590B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55306A (en) * 1978-04-28 1980-01-05 Bristol Myers Co Manufacture of 11nn*omegaaaminooalphaahydroxy alkanoyl**aminoglycoside antibiotic
KR20040085203A (en) * 2002-02-19 2004-10-07 아마토 세이야쿠 가부시키가이샤 Lactic Acid Derivative
CN101868472B (en) 2007-11-21 2013-05-29 尔察祯有限公司 Antibacterial aminoglycoside analogs
WO2010132765A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132759A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of dibekacin
WO2010132757A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132768A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of sisomicin
WO2010132760A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of tobramycin

Also Published As

Publication number Publication date
YU102578A (en) 1983-01-21
NO154697C (en) 1986-12-03
ES469303A1 (en) 1979-09-16
JPS5721277B2 (en) 1982-05-06
AT357675B (en) 1980-07-25
NL178790C (en) 1986-05-16
DK172543B1 (en) 1998-12-07
DE2818992C2 (en) 1988-03-17
DE2818822C2 (en) 1989-01-26
KE3398A (en) 1984-06-08
FR2388827A1 (en) 1978-11-24
IT1105500B (en) 1985-11-04
SE8305538D0 (en) 1983-10-07
CY1241A (en) 1984-06-29
SE7804973L (en) 1978-10-29
DK165450B (en) 1992-11-30
CH639104A5 (en) 1983-10-31
FR2388826A1 (en) 1978-11-24
MY8500528A (en) 1985-12-31
SE8305538L (en) 1983-10-07
NO149635C (en) 1984-05-23
DK183078A (en) 1978-10-29
EG13710A (en) 1982-09-30
PT67959B (en) 1980-03-05
NO154697B (en) 1986-08-25
GB1598294A (en) 1981-09-16
DK165450C (en) 1993-04-13
IT7849136A0 (en) 1978-04-28
SE447259B (en) 1986-11-03
DK182978A (en) 1978-10-29
IT1156718B (en) 1987-02-04
PT67959A (en) 1978-05-01
DE2818992A1 (en) 1978-11-23
YU102478A (en) 1982-10-31
NO781437L (en) 1978-10-31
NO831197L (en) 1978-10-31
PL206457A1 (en) 1980-03-24
AR218910A1 (en) 1980-07-15
SE461148B (en) 1990-01-15
IE46945B1 (en) 1983-11-16
ATA312778A (en) 1979-12-15
FR2388827B1 (en) 1982-07-09
FR2388826B1 (en) 1982-12-10
CA1100953A (en) 1981-05-12
LU79541A1 (en) 1978-11-28
DE2818822A1 (en) 1978-11-09
FI781288A (en) 1978-10-29
SG22884G (en) 1985-01-04
CS207607B2 (en) 1981-08-31
YU41590B (en) 1987-12-31
CA1105454A (en) 1981-07-21
NO149635B (en) 1984-02-13
JPS53149951A (en) 1978-12-27
IT7849137A0 (en) 1978-04-28
IE780842L (en) 1978-10-28
IE47271B1 (en) 1984-02-08
NL178790B (en) 1985-12-16
PL117307B1 (en) 1981-07-31
NL7804503A (en) 1978-10-31
HK51484A (en) 1984-06-22

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Legal Events

Date Code Title Description
MK9A Patent expired