ES469303A1 - Process for the preparation of kanamycin derivatives - Google Patents

Process for the preparation of kanamycin derivatives

Info

Publication number
ES469303A1
ES469303A1 ES469303A ES469303A ES469303A1 ES 469303 A1 ES469303 A1 ES 469303A1 ES 469303 A ES469303 A ES 469303A ES 469303 A ES469303 A ES 469303A ES 469303 A1 ES469303 A1 ES 469303A1
Authority
ES
Spain
Prior art keywords
amino
preparation
formula
image
kanamycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES469303A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES469303A1 publication Critical patent/ES469303A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1-N-[ omega -amino- alpha -hydroxyalkanoyl] kanamycins A and B of the formula I < IMAGE > in which R represents OH or NH2, are prepared by acylation of polysilylated kanamycin A or B, or polysilylated kanamycin A or B which has a protective group other than silyl on the 6'-amino group, with an acylating derivative of an acid of the formula II < IMAGE > in which n is an integer from 0 to 2 and B is an amino protective group, in an essentially anhydrous organic solvent and by subsequent removal of all blocking groups. The compounds have therapeutic properties.
ES469303A 1977-04-28 1978-04-28 Process for the preparation of kanamycin derivatives Expired ES469303A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79180677A 1977-04-28 1977-04-28
US88858578A 1978-03-20 1978-03-20

Publications (1)

Publication Number Publication Date
ES469303A1 true ES469303A1 (en) 1979-09-16

Family

ID=27121201

Family Applications (1)

Application Number Title Priority Date Filing Date
ES469303A Expired ES469303A1 (en) 1977-04-28 1978-04-28 Process for the preparation of kanamycin derivatives

Country Status (27)

Country Link
JP (1) JPS53149951A (en)
AR (1) AR218910A1 (en)
AT (1) AT357675B (en)
CA (2) CA1105454A (en)
CH (1) CH639104A5 (en)
CS (1) CS207607B2 (en)
CY (1) CY1241A (en)
DE (2) DE2818992A1 (en)
DK (2) DK165450C (en)
EG (1) EG13710A (en)
ES (1) ES469303A1 (en)
FI (1) FI781288A (en)
FR (2) FR2388827A1 (en)
GB (1) GB1598294A (en)
HK (1) HK51484A (en)
IE (2) IE46945B1 (en)
IT (2) IT1156718B (en)
KE (1) KE3398A (en)
LU (1) LU79541A1 (en)
MY (1) MY8500528A (en)
NL (1) NL178790C (en)
NO (2) NO149635C (en)
PL (1) PL117307B1 (en)
PT (1) PT67959B (en)
SE (2) SE447259B (en)
SG (1) SG22884G (en)
YU (2) YU102578A (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55306A (en) * 1978-04-28 1980-01-05 Bristol Myers Co Manufacture of 11nn*omegaaaminooalphaahydroxy alkanoyl**aminoglycoside antibiotic
EP1484317A4 (en) * 2002-02-19 2006-08-30 Amato Pharm Prod Ltd Lactic acid derivative
EP3150617B1 (en) 2007-11-21 2020-04-08 Cipla USA, Inc. Antibacterial aminoglycoside analogs
WO2010132768A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of sisomicin
WO2010132757A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132759A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of dibekacin
WO2010132765A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132760A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of tobramycin

Also Published As

Publication number Publication date
NO149635B (en) 1984-02-13
YU102478A (en) 1982-10-31
CY1241A (en) 1984-06-29
PL117307B1 (en) 1981-07-31
IE47271B1 (en) 1984-02-08
FR2388826A1 (en) 1978-11-24
SE461148B (en) 1990-01-15
IE780842L (en) 1978-10-28
NL7804503A (en) 1978-10-31
JPS5721277B2 (en) 1982-05-06
DE2818822C2 (en) 1989-01-26
IE46945B1 (en) 1983-11-16
IT1156718B (en) 1987-02-04
NO781437L (en) 1978-10-31
SE7804973L (en) 1978-10-29
NO831197L (en) 1978-10-31
NO149635C (en) 1984-05-23
ATA312778A (en) 1979-12-15
DK172543B1 (en) 1998-12-07
CH639104A5 (en) 1983-10-31
CA1105454A (en) 1981-07-21
IT7849137A0 (en) 1978-04-28
FR2388827B1 (en) 1982-07-09
DE2818992C2 (en) 1988-03-17
LU79541A1 (en) 1978-11-28
NL178790C (en) 1986-05-16
PT67959B (en) 1980-03-05
NO154697B (en) 1986-08-25
SE447259B (en) 1986-11-03
MY8500528A (en) 1985-12-31
DK183078A (en) 1978-10-29
EG13710A (en) 1982-09-30
JPS53149951A (en) 1978-12-27
NO154697C (en) 1986-12-03
FI781288A (en) 1978-10-29
DE2818822A1 (en) 1978-11-09
KE3398A (en) 1984-06-08
DE2818992A1 (en) 1978-11-23
NL178790B (en) 1985-12-16
DK182978A (en) 1978-10-29
YU41590B (en) 1987-12-31
GB1598294A (en) 1981-09-16
YU102578A (en) 1983-01-21
SE8305538L (en) 1983-10-07
SG22884G (en) 1985-01-04
IT1105500B (en) 1985-11-04
PL206457A1 (en) 1980-03-24
IT7849136A0 (en) 1978-04-28
HK51484A (en) 1984-06-22
CS207607B2 (en) 1981-08-31
DK165450B (en) 1992-11-30
SE8305538D0 (en) 1983-10-07
IE780841L (en) 1978-10-28
AT357675B (en) 1980-07-25
CA1100953A (en) 1981-05-12
DK165450C (en) 1993-04-13
FR2388827A1 (en) 1978-11-24
AR218910A1 (en) 1980-07-15
FR2388826B1 (en) 1982-12-10
PT67959A (en) 1978-05-01

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