FR2388827A1 - PROCESS FOR THE PRODUCTION OF 1-N- (O-AMINO-A-HYDROXYALCANOYL) -AMINOGLYCOSIDIC ANTIBIOTICS - Google Patents
PROCESS FOR THE PRODUCTION OF 1-N- (O-AMINO-A-HYDROXYALCANOYL) -AMINOGLYCOSIDIC ANTIBIOTICSInfo
- Publication number
- FR2388827A1 FR2388827A1 FR7812591A FR7812591A FR2388827A1 FR 2388827 A1 FR2388827 A1 FR 2388827A1 FR 7812591 A FR7812591 A FR 7812591A FR 7812591 A FR7812591 A FR 7812591A FR 2388827 A1 FR2388827 A1 FR 2388827A1
- Authority
- FR
- France
- Prior art keywords
- amino
- groups
- hydroxyalcanoyl
- production
- aminoglycoside
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
L'invention concerne un procédé de préparation d'un 1-N-Ø omega -amino- alpha -hydroxyalcanoylõ aminoglycoside ou d'un sel d'addition d'acide acceptable du point de vue pharmaceutique de ce composé. Le procédé consiste à faire réagir un aminoglycoside polysilylé renfermant éventuellement un à trois groupes autres que les groupes silyle protégeant des fonctions amino autres que la fonction amino en C-1, dans un solvant organique sensiblement anhydre, avec un dérivé acylant d'un acide hydroxycarboxylique aminé à groupe amino protégé, puis à éliminer tous les groupes protecteurs. Les composés obtenus par le procédé de l'invention sont des antibiotiques.Disclosed is a process for preparing a 1-N-Ø omega -amino-alpha -hydroxyalkanoylõ aminoglycoside or a pharmaceutically acceptable acid addition salt thereof. The process consists in reacting a polysilylated aminoglycoside optionally containing one to three groups other than the silyl groups protecting amino functions other than the C-1 amino function, in a substantially anhydrous organic solvent, with an acylating derivative of a hydroxycarboxylic acid amino to protected amino group, then removing all protecting groups. The compounds obtained by the process of the invention are antibiotics.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79180677A | 1977-04-28 | 1977-04-28 | |
| US88858578A | 1978-03-20 | 1978-03-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2388827A1 true FR2388827A1 (en) | 1978-11-24 |
| FR2388827B1 FR2388827B1 (en) | 1982-07-09 |
Family
ID=27121201
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7812589A Granted FR2388826A1 (en) | 1977-04-28 | 1978-04-27 | PREPARATION OF 1-N- (O) AMINO-A-HYDROXYALKANOY) KANAMYCINS |
| FR7812591A Granted FR2388827A1 (en) | 1977-04-28 | 1978-04-27 | PROCESS FOR THE PRODUCTION OF 1-N- (O-AMINO-A-HYDROXYALCANOYL) -AMINOGLYCOSIDIC ANTIBIOTICS |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7812589A Granted FR2388826A1 (en) | 1977-04-28 | 1978-04-27 | PREPARATION OF 1-N- (O) AMINO-A-HYDROXYALKANOY) KANAMYCINS |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPS53149951A (en) |
| AR (1) | AR218910A1 (en) |
| AT (1) | AT357675B (en) |
| CA (2) | CA1105454A (en) |
| CH (1) | CH639104A5 (en) |
| CS (1) | CS207607B2 (en) |
| CY (1) | CY1241A (en) |
| DE (2) | DE2818822A1 (en) |
| DK (2) | DK165450C (en) |
| EG (1) | EG13710A (en) |
| ES (1) | ES469303A1 (en) |
| FI (1) | FI781288A (en) |
| FR (2) | FR2388826A1 (en) |
| GB (1) | GB1598294A (en) |
| HK (1) | HK51484A (en) |
| IE (2) | IE46945B1 (en) |
| IT (2) | IT1156718B (en) |
| KE (1) | KE3398A (en) |
| LU (1) | LU79541A1 (en) |
| MY (1) | MY8500528A (en) |
| NL (1) | NL178790C (en) |
| NO (2) | NO149635C (en) |
| PL (1) | PL117307B1 (en) |
| PT (1) | PT67959B (en) |
| SE (2) | SE447259B (en) |
| SG (1) | SG22884G (en) |
| YU (2) | YU41590B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55306A (en) * | 1978-04-28 | 1980-01-05 | Bristol Myers Co | Manufacture of 11nn*omegaaaminooalphaahydroxy alkanoyl**aminoglycoside antibiotic |
| CN1646484A (en) * | 2002-02-19 | 2005-07-27 | 天藤制药株式会社 | Lactic acid derivative |
| KR101296099B1 (en) | 2007-11-21 | 2014-02-26 | 아카오젠, 인코포레이티드 | Antibacterial aminoglycoside analogs |
| WO2010132759A1 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial derivatives of dibekacin |
| WO2010132757A2 (en) * | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
| WO2010132760A1 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial derivatives of tobramycin |
| WO2010132765A2 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
| WO2010132768A1 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial derivatives of sisomicin |
-
1978
- 1978-04-21 AR AR271852A patent/AR218910A1/en active
- 1978-04-25 CA CA301,968A patent/CA1105454A/en not_active Expired
- 1978-04-25 FI FI781288A patent/FI781288A/en not_active Application Discontinuation
- 1978-04-25 CA CA301,962A patent/CA1100953A/en not_active Expired
- 1978-04-25 NO NO781437A patent/NO149635C/en unknown
- 1978-04-26 DK DK182978A patent/DK165450C/en not_active IP Right Cessation
- 1978-04-26 NL NLAANVRAGE7804503,A patent/NL178790C/en not_active IP Right Cessation
- 1978-04-26 GB GB16571/78A patent/GB1598294A/en not_active Expired
- 1978-04-26 DK DK197801830A patent/DK172543B1/en not_active IP Right Cessation
- 1978-04-26 CY CY1241A patent/CY1241A/en unknown
- 1978-04-27 YU YU1024/78A patent/YU41590B/en unknown
- 1978-04-27 YU YU01025/78A patent/YU102578A/en unknown
- 1978-04-27 FR FR7812589A patent/FR2388826A1/en active Granted
- 1978-04-27 IE IE841/78A patent/IE46945B1/en not_active IP Right Cessation
- 1978-04-27 CS CS782729A patent/CS207607B2/en unknown
- 1978-04-27 LU LU79541A patent/LU79541A1/en unknown
- 1978-04-27 PT PT67959A patent/PT67959B/en unknown
- 1978-04-27 FR FR7812591A patent/FR2388827A1/en active Granted
- 1978-04-27 IE IE842/78A patent/IE47271B1/en not_active IP Right Cessation
- 1978-04-28 DE DE19782818822 patent/DE2818822A1/en active Granted
- 1978-04-28 ES ES469303A patent/ES469303A1/en not_active Expired
- 1978-04-28 SE SE7804973A patent/SE447259B/en not_active IP Right Cessation
- 1978-04-28 DE DE19782818992 patent/DE2818992A1/en active Granted
- 1978-04-28 IT IT49136/78A patent/IT1156718B/en active
- 1978-04-28 CH CH470278A patent/CH639104A5/en not_active IP Right Cessation
- 1978-04-28 JP JP5016078A patent/JPS53149951A/en active Granted
- 1978-04-28 IT IT49137/78A patent/IT1105500B/en active
- 1978-04-28 PL PL1978206457A patent/PL117307B1/en unknown
- 1978-04-28 AT AT312778A patent/AT357675B/en not_active IP Right Cessation
- 1978-04-29 EG EG283/78A patent/EG13710A/en active
-
1983
- 1983-04-05 NO NO83831197A patent/NO154697C/en unknown
- 1983-10-07 SE SE8305538A patent/SE461148B/en not_active IP Right Cessation
-
1984
- 1984-03-12 SG SG228/84A patent/SG22884G/en unknown
- 1984-04-12 KE KE3398A patent/KE3398A/en unknown
- 1984-06-22 HK HK514/84A patent/HK51484A/en not_active IP Right Cessation
-
1985
- 1985-12-30 MY MY528/85A patent/MY8500528A/en unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CC | Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990) |
Free format text: 92C0103, 920429 |
|
| CD | Change of name or company name | ||
| CB | Supplementary protection certificate (spc) granted (law of 25 june 1990) |
Free format text: 92C0103, 780427 |
|
| CL | Concession to grant licences |