FR2376847A1 - IMPROVED PROCESS FOR TRANSPOSITION OF MORPHINES INTO APOMORPHINS - Google Patents

IMPROVED PROCESS FOR TRANSPOSITION OF MORPHINES INTO APOMORPHINS

Info

Publication number
FR2376847A1
FR2376847A1 FR7739473A FR7739473A FR2376847A1 FR 2376847 A1 FR2376847 A1 FR 2376847A1 FR 7739473 A FR7739473 A FR 7739473A FR 7739473 A FR7739473 A FR 7739473A FR 2376847 A1 FR2376847 A1 FR 2376847A1
Authority
FR
France
Prior art keywords
transposition
apomorphins
morphines
improved process
degrees
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7739473A
Other languages
French (fr)
Other versions
FR2376847B1 (en
Inventor
Roman Richard Lorenz
Edward David Parady
Et William Henry Thielking
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of FR2376847A1 publication Critical patent/FR2376847A1/en
Application granted granted Critical
Publication of FR2376847B1 publication Critical patent/FR2376847B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

L'invention concerne la préparation de dérivés d'apomorphine avec un rendement amélioré, par transposition du dérivé de morphine correspondant en présence d'acide phosphorique anhydre sous un vide partiel, genéralement compris entre 9 et 20 mm de mercure et à une température comprise entre 125 degrés C et 140 degrés C.The invention relates to the preparation of apomorphine derivatives with improved yield, by transposition of the corresponding morphine derivative in the presence of anhydrous phosphoric acid under a partial vacuum, generally between 9 and 20 mm of mercury and at a temperature between 125 degrees C and 140 degrees C.

FR7739473A 1977-01-10 1977-12-28 IMPROVED PROCESS FOR TRANSPOSITION OF MORPHINES INTO APOMORPHINS Granted FR2376847A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75788877A 1977-01-10 1977-01-10

Publications (2)

Publication Number Publication Date
FR2376847A1 true FR2376847A1 (en) 1978-08-04
FR2376847B1 FR2376847B1 (en) 1980-08-22

Family

ID=25049636

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7739473A Granted FR2376847A1 (en) 1977-01-10 1977-12-28 IMPROVED PROCESS FOR TRANSPOSITION OF MORPHINES INTO APOMORPHINS

Country Status (14)

Country Link
JP (1) JPS5387359A (en)
AU (1) AU510976B2 (en)
BE (1) BE862389A (en)
CA (1) CA1092122A (en)
CH (1) CH624674A5 (en)
DE (1) DE2758954A1 (en)
DK (1) DK584077A (en)
FR (1) FR2376847A1 (en)
GB (1) GB1566049A (en)
IE (1) IE45922B1 (en)
LU (1) LU78790A1 (en)
NL (1) NL7714227A (en)
NZ (1) NZ185799A (en)
SE (1) SE7713456L (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3171561D1 (en) * 1980-05-08 1985-09-05 Univ Northeastern N-substituted aporphines, a method of inducing emesis and a method of controlling psychosis utilising the same
WO1990012574A1 (en) * 1989-04-25 1990-11-01 Northeastern University Dopamine agonist compounds
GB201915911D0 (en) * 2019-11-01 2019-12-18 Johnson Matthey Plc Process

Also Published As

Publication number Publication date
NZ185799A (en) 1979-12-11
NL7714227A (en) 1978-07-12
BE862389A (en) 1978-06-28
JPS5387359A (en) 1978-08-01
CA1092122A (en) 1980-12-23
SE7713456L (en) 1978-07-11
CH624674A5 (en) 1981-08-14
IE45922B1 (en) 1982-12-29
IE45922L (en) 1978-07-10
DK584077A (en) 1978-07-11
AU3101377A (en) 1979-06-07
AU510976B2 (en) 1980-07-24
GB1566049A (en) 1980-04-30
LU78790A1 (en) 1978-07-11
FR2376847B1 (en) 1980-08-22
DE2758954A1 (en) 1978-07-13

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Legal Events

Date Code Title Description
ST Notification of lapse