IE45922L - Improved morphine/apomorphine rearrangement process - Google Patents

Improved morphine/apomorphine rearrangement process

Info

Publication number
IE45922L
IE45922L IE237377A IE237377A IE45922L IE 45922 L IE45922 L IE 45922L IE 237377 A IE237377 A IE 237377A IE 237377 A IE237377 A IE 237377A IE 45922 L IE45922 L IE 45922L
Authority
IE
Ireland
Prior art keywords
apomorphine
rearrangement process
improved
morphine
improved morphine
Prior art date
Application number
IE237377A
Other versions
IE45922B1 (en
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of IE45922L publication Critical patent/IE45922L/en
Publication of IE45922B1 publication Critical patent/IE45922B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Apomorphine derivatives are prepared with an improved yield by transposition of the corresponding morphine derivative in the presence of anhydrous phosphoric acid under a partial vacuum, generally between 9 and 20 mm of mercury and at a temperature between 125 DEG C and 140 DEG C. [GB1566049A]
IE237377A 1977-01-10 1977-11-23 Improved morphine/apomorphine rearrangement process IE45922B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75788877A 1977-01-10 1977-01-10

Publications (2)

Publication Number Publication Date
IE45922L true IE45922L (en) 1978-07-10
IE45922B1 IE45922B1 (en) 1982-12-29

Family

ID=25049636

Family Applications (1)

Application Number Title Priority Date Filing Date
IE237377A IE45922B1 (en) 1977-01-10 1977-11-23 Improved morphine/apomorphine rearrangement process

Country Status (14)

Country Link
JP (1) JPS5387359A (en)
AU (1) AU510976B2 (en)
BE (1) BE862389A (en)
CA (1) CA1092122A (en)
CH (1) CH624674A5 (en)
DE (1) DE2758954A1 (en)
DK (1) DK584077A (en)
FR (1) FR2376847A1 (en)
GB (1) GB1566049A (en)
IE (1) IE45922B1 (en)
LU (1) LU78790A1 (en)
NL (1) NL7714227A (en)
NZ (1) NZ185799A (en)
SE (1) SE7713456L (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3171561D1 (en) * 1980-05-08 1985-09-05 Univ Northeastern N-substituted aporphines, a method of inducing emesis and a method of controlling psychosis utilising the same
WO1990012574A1 (en) * 1989-04-25 1990-11-01 Northeastern University Dopamine agonist compounds
GB201915911D0 (en) * 2019-11-01 2019-12-18 Johnson Matthey Plc Process

Also Published As

Publication number Publication date
DE2758954A1 (en) 1978-07-13
DK584077A (en) 1978-07-11
FR2376847B1 (en) 1980-08-22
NL7714227A (en) 1978-07-12
AU510976B2 (en) 1980-07-24
GB1566049A (en) 1980-04-30
CA1092122A (en) 1980-12-23
IE45922B1 (en) 1982-12-29
AU3101377A (en) 1979-06-07
FR2376847A1 (en) 1978-08-04
CH624674A5 (en) 1981-08-14
NZ185799A (en) 1979-12-11
BE862389A (en) 1978-06-28
LU78790A1 (en) 1978-07-11
JPS5387359A (en) 1978-08-01
SE7713456L (en) 1978-07-11

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