SE8305538L - POLYSILYLATED CANAMYCINE A OR B AS INTERMEDIATE IN THE PREPARATION OF CANAMYCINE A AND B DERIVATIVES - Google Patents

POLYSILYLATED CANAMYCINE A OR B AS INTERMEDIATE IN THE PREPARATION OF CANAMYCINE A AND B DERIVATIVES

Info

Publication number
SE8305538L
SE8305538L SE8305538A SE8305538A SE8305538L SE 8305538 L SE8305538 L SE 8305538L SE 8305538 A SE8305538 A SE 8305538A SE 8305538 A SE8305538 A SE 8305538A SE 8305538 L SE8305538 L SE 8305538L
Authority
SE
Sweden
Prior art keywords
canamycine
polysilylated
amino
derivatives
preparation
Prior art date
Application number
SE8305538A
Other languages
Swedish (sv)
Other versions
SE8305538D0 (en
SE461148B (en
Inventor
Martin John Cron
John Gerard Keil
Jeng Shyong Lin
Mariano Vecchio Ruggeri
Derek Walker
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of SE8305538D0 publication Critical patent/SE8305538D0/en
Publication of SE8305538L publication Critical patent/SE8305538L/en
Publication of SE461148B publication Critical patent/SE461148B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1-N-[ omega -amino- alpha -hydroxyalkanoyl] kanamycins A and B of the formula I in which R represents OH or NH2, are prepared by acylation of polysilylated kanamycin A or B, or polysilylated kanamycin A or B which has a protective group other than silyl on the 6'-amino group, with an acylating derivative of an acid of the formula II in which n is an integer from 0 to 2 and B is an amino protective group, in an essentially anhydrous organic solvent and by subsequent removal of all blocking groups. The compounds have therapeutic properties.

Claims (1)

Patentkrav Polysilylerat kanamycin A eller B eller polysilylerat kanamycin A eller B innehEllande en annan blockeringsgrupp En silyl p& 6'-aminogruppen son mellanprodukt vid framstEllning av derivat av kanamycin A och B.Polysilylated kanamycin A or B or polysilylated kanamycin A or B containing another blocking group A silyl p & 6 'amino group is an intermediate in the preparation of derivatives of kanamycin A and B.
SE8305538A 1977-04-28 1983-10-07 POLYSILYLATED CANAMYCIN A OR B DERIVATE SE461148B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79180677A 1977-04-28 1977-04-28
US88858578A 1978-03-20 1978-03-20

Publications (3)

Publication Number Publication Date
SE8305538D0 SE8305538D0 (en) 1983-10-07
SE8305538L true SE8305538L (en) 1983-10-07
SE461148B SE461148B (en) 1990-01-15

Family

ID=27121201

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7804973A SE447259B (en) 1977-04-28 1978-04-28 PROCEDURE FOR PREPARING A 1-N- / L - (-) - OMEGA-AMINO-ALFA-HYDROXIAL CANOYL / CANAMYCINE A OR B
SE8305538A SE461148B (en) 1977-04-28 1983-10-07 POLYSILYLATED CANAMYCIN A OR B DERIVATE

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7804973A SE447259B (en) 1977-04-28 1978-04-28 PROCEDURE FOR PREPARING A 1-N- / L - (-) - OMEGA-AMINO-ALFA-HYDROXIAL CANOYL / CANAMYCINE A OR B

Country Status (27)

Country Link
JP (1) JPS53149951A (en)
AR (1) AR218910A1 (en)
AT (1) AT357675B (en)
CA (2) CA1105454A (en)
CH (1) CH639104A5 (en)
CS (1) CS207607B2 (en)
CY (1) CY1241A (en)
DE (2) DE2818822A1 (en)
DK (2) DK165450C (en)
EG (1) EG13710A (en)
ES (1) ES469303A1 (en)
FI (1) FI781288A (en)
FR (2) FR2388826A1 (en)
GB (1) GB1598294A (en)
HK (1) HK51484A (en)
IE (2) IE46945B1 (en)
IT (2) IT1156718B (en)
KE (1) KE3398A (en)
LU (1) LU79541A1 (en)
MY (1) MY8500528A (en)
NL (1) NL178790C (en)
NO (2) NO149635C (en)
PL (1) PL117307B1 (en)
PT (1) PT67959B (en)
SE (2) SE447259B (en)
SG (1) SG22884G (en)
YU (2) YU41590B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55306A (en) * 1978-04-28 1980-01-05 Bristol Myers Co Manufacture of 11nn*omegaaaminooalphaahydroxy alkanoyl**aminoglycoside antibiotic
CN1646484A (en) * 2002-02-19 2005-07-27 天藤制药株式会社 Lactic acid derivative
KR101296099B1 (en) 2007-11-21 2014-02-26 아카오젠, 인코포레이티드 Antibacterial aminoglycoside analogs
WO2010132759A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of dibekacin
WO2010132757A2 (en) * 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132760A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of tobramycin
WO2010132765A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132768A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of sisomicin

Also Published As

Publication number Publication date
CS207607B2 (en) 1981-08-31
AR218910A1 (en) 1980-07-15
LU79541A1 (en) 1978-11-28
CA1100953A (en) 1981-05-12
NL178790B (en) 1985-12-16
DK182978A (en) 1978-10-29
KE3398A (en) 1984-06-08
DE2818992A1 (en) 1978-11-23
IT7849137A0 (en) 1978-04-28
SE7804973L (en) 1978-10-29
IE780841L (en) 1978-10-28
AT357675B (en) 1980-07-25
NO149635C (en) 1984-05-23
CY1241A (en) 1984-06-29
FR2388827B1 (en) 1982-07-09
DK183078A (en) 1978-10-29
YU102578A (en) 1983-01-21
PT67959A (en) 1978-05-01
JPS53149951A (en) 1978-12-27
DK165450B (en) 1992-11-30
DE2818822C2 (en) 1989-01-26
PL206457A1 (en) 1980-03-24
YU41590B (en) 1987-12-31
NL178790C (en) 1986-05-16
GB1598294A (en) 1981-09-16
NO781437L (en) 1978-10-31
FR2388826A1 (en) 1978-11-24
CH639104A5 (en) 1983-10-31
DK165450C (en) 1993-04-13
IE780842L (en) 1978-10-28
ES469303A1 (en) 1979-09-16
JPS5721277B2 (en) 1982-05-06
DE2818992C2 (en) 1988-03-17
EG13710A (en) 1982-09-30
IT7849136A0 (en) 1978-04-28
YU102478A (en) 1982-10-31
DE2818822A1 (en) 1978-11-09
IE46945B1 (en) 1983-11-16
SE447259B (en) 1986-11-03
IE47271B1 (en) 1984-02-08
CA1105454A (en) 1981-07-21
ATA312778A (en) 1979-12-15
NO154697C (en) 1986-12-03
IT1156718B (en) 1987-02-04
MY8500528A (en) 1985-12-31
DK172543B1 (en) 1998-12-07
IT1105500B (en) 1985-11-04
PL117307B1 (en) 1981-07-31
NL7804503A (en) 1978-10-31
SG22884G (en) 1985-01-04
FI781288A (en) 1978-10-29
FR2388826B1 (en) 1982-12-10
SE8305538D0 (en) 1983-10-07
PT67959B (en) 1980-03-05
NO149635B (en) 1984-02-13
NO154697B (en) 1986-08-25
NO831197L (en) 1978-10-31
HK51484A (en) 1984-06-22
FR2388827A1 (en) 1978-11-24
SE461148B (en) 1990-01-15

Similar Documents

Publication Publication Date Title
CA2054619A1 (en) Aminocoumaran derivatives, their production and use
PE50196A1 (en) PROCEDURE TO PURIFY AND ISOLATE 2`-DEOXI-2 ', 2'-DIFLUORONUCLEOSIDE
MY103912A (en) Adriamycin
SE8305538L (en) POLYSILYLATED CANAMYCINE A OR B AS INTERMEDIATE IN THE PREPARATION OF CANAMYCINE A AND B DERIVATIVES
GB1080491A (en) A process for the manufacture of nucleosides
JPS5461151A (en) Novel aminoglycoside derivative
ES457793A1 (en) Process for the preparation of aminoglycoside antibiotics and intermediates therefor
ES442144A1 (en) 4{40 -Epi-6{40 -hydroxyadriamycin and method of use
FI800779A (en) PEPTIDER MED UBIKITIN LIKNANDE AKTIVITET
ATE136550T1 (en) 9-DEOXO-9A-AZA-11-DEOXY-9A-HOMOERYTHROMYCIN A 9A, 11-CYCLIC CARBAMATES
IE42957L (en) Rosamicin (antibiotic 67-694) derivatives.
GB1530643A (en) Aminoglycosides
JPS5488242A (en) Novel derivative of fortimicin b and its preparation
ATE3046T1 (en) AN AMINO-SUGAR CONTAINING POLYEN MACROLIDIANT ANTIBIOTIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
ATE9584T1 (en) BETA-LACTAM ANTIBACTERIAL COMPOUNDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
SE7910734L (en) 3 ', 4'-DIDEOXICANAMYCINE AND 1-N- (ALF-HYDROXY-OMEGA-AMINO-ALKANOYL) DERIVATIVE THEREOF
JPS5581897A (en) Preparation of 1-n-isoseryl-or 1-n-(l-4-amino-2-hydroxybutyryl)-3',4'-dideoxykanamycin b
SE8302517L (en) PROCEDURE FOR THE PREPARATION OF ANTIBIOTIC C-15003 P-0 (MAYTANSINOL)
JPS56152476A (en) Novel minimycin derivative
GB1458586A (en) Antiviral complexes of double stranded rna and its derivatives
JPS5432493A (en) Preparation of macrolide antibiotics derivatives
JPS55120516A (en) Antitumor drug comprising organic silicon compound as chief ingredient
JPS5651499A (en) Aminoglycoside derivative and its preparation
ES435375A1 (en) Derivative of antibiotic xk-62-2 and method of production thereof
ES404747A1 (en) Derivatives of kanamycin a and b and a process for the preparation thereof

Legal Events

Date Code Title Description
NAL Patent in force

Ref document number: 8305538-4

Format of ref document f/p: F

NUG Patent has lapsed

Ref document number: 8305538-4

Format of ref document f/p: F