ES435375A1 - Derivative of antibiotic xk-62-2 and method of production thereof - Google Patents
Derivative of antibiotic xk-62-2 and method of production thereofInfo
- Publication number
- ES435375A1 ES435375A1 ES435375A ES435375A ES435375A1 ES 435375 A1 ES435375 A1 ES 435375A1 ES 435375 A ES435375 A ES 435375A ES 435375 A ES435375 A ES 435375A ES 435375 A1 ES435375 A1 ES 435375A1
- Authority
- ES
- Spain
- Prior art keywords
- antibiotic
- group
- protective
- gram
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
- C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A novel antibiotic with high antibacterial activity against Gram-positive and Gram-negative bacteria, especially bacteria which are resistant to aminoglycoside antibiotics, is prepared. This entails acylation of the antibiotic XK-62-2 of the formula II, which is obtained by cultivation of actinomycetes, < IMAGE > in which, where appropriate, at least one of the amino groups in position 2' and 6' undergoes intermediate protection, in position 1 using 0.4 to 2.5 mole equivalents of a compound which is able to introduce an alpha -hydroxybeta -aminopropionyl group in which the beta -amino group is substituted by at least one protective group chosen from the protective groups listed in Claim 1. The reaction takes place in a solvent at -50 to 50 DEG C, and subsequently the protective group or protective groups are eliminated.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2575374A JPS573679B2 (en) | 1974-03-07 | 1974-03-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES435375A1 true ES435375A1 (en) | 1977-05-01 |
Family
ID=12174581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES435375A Expired ES435375A1 (en) | 1974-03-07 | 1975-03-06 | Derivative of antibiotic xk-62-2 and method of production thereof |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS573679B2 (en) |
| AT (1) | AT340588B (en) |
| CA (1) | CA1046057A (en) |
| CH (1) | CH613710A5 (en) |
| DE (1) | DE2509885C3 (en) |
| DK (1) | DK88475A (en) |
| ES (1) | ES435375A1 (en) |
| FR (1) | FR2263251B1 (en) |
| GB (1) | GB1500218A (en) |
| NL (1) | NL7502740A (en) |
| NO (1) | NO140428C (en) |
| PH (1) | PH13670A (en) |
| SE (1) | SE416208B (en) |
| ZA (1) | ZA751414B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4136254A (en) | 1976-06-17 | 1979-01-23 | Schering Corporation | Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby |
| EP0000057B1 (en) * | 1977-06-10 | 1982-07-14 | Bayer Ag | Selectively protected 4,6-di-o-(aminoglycosyl)-1,3-diamino-cyclitols |
-
1974
- 1974-03-07 JP JP2575374A patent/JPS573679B2/ja not_active Expired
-
1975
- 1975-03-04 NO NO750720A patent/NO140428C/en unknown
- 1975-03-05 GB GB9134/75A patent/GB1500218A/en not_active Expired
- 1975-03-05 DK DK88475*#A patent/DK88475A/da unknown
- 1975-03-05 PH PH16870A patent/PH13670A/en unknown
- 1975-03-05 SE SE7502449A patent/SE416208B/en unknown
- 1975-03-06 AT AT173875A patent/AT340588B/en not_active IP Right Cessation
- 1975-03-06 FR FR7507097A patent/FR2263251B1/fr not_active Expired
- 1975-03-06 ES ES435375A patent/ES435375A1/en not_active Expired
- 1975-03-06 DE DE2509885A patent/DE2509885C3/en not_active Expired
- 1975-03-06 CA CA221,422A patent/CA1046057A/en not_active Expired
- 1975-03-07 NL NL7502740A patent/NL7502740A/en not_active Application Discontinuation
- 1975-03-07 CH CH292175A patent/CH613710A5/en not_active IP Right Cessation
- 1975-03-07 ZA ZA00751414A patent/ZA751414B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB1500218A (en) | 1978-02-08 |
| SE416208B (en) | 1980-12-08 |
| ATA173875A (en) | 1977-04-15 |
| NO750720L (en) | 1975-09-09 |
| NL7502740A (en) | 1975-09-09 |
| FR2263251A1 (en) | 1975-10-03 |
| DE2509885C3 (en) | 1978-08-17 |
| CH613710A5 (en) | 1979-10-15 |
| DE2509885B2 (en) | 1977-12-08 |
| PH13670A (en) | 1980-08-26 |
| CA1046057A (en) | 1979-01-09 |
| AT340588B (en) | 1977-12-27 |
| DE2509885A1 (en) | 1975-09-11 |
| JPS573679B2 (en) | 1982-01-22 |
| NO140428B (en) | 1979-05-21 |
| NO140428C (en) | 1979-08-29 |
| FR2263251B1 (en) | 1977-07-22 |
| DK88475A (en) | 1975-09-08 |
| JPS50117748A (en) | 1975-09-16 |
| ZA751414B (en) | 1976-10-27 |
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