SE7511229L - ANTIQUE BACTERIAL AGENT - Google Patents

ANTIQUE BACTERIAL AGENT

Info

Publication number
SE7511229L
SE7511229L SE7511229A SE7511229A SE7511229L SE 7511229 L SE7511229 L SE 7511229L SE 7511229 A SE7511229 A SE 7511229A SE 7511229 A SE7511229 A SE 7511229A SE 7511229 L SE7511229 L SE 7511229L
Authority
SE
Sweden
Prior art keywords
amino
protective group
amino protective
alpha
hydrogen
Prior art date
Application number
SE7511229A
Other languages
Swedish (sv)
Other versions
SE431216B (en
Inventor
H Umezawa
K Maeda
S Kondo
S Umezawa
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of SE7511229L publication Critical patent/SE7511229L/en
Publication of SE431216B publication Critical patent/SE431216B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Physical Vapour Deposition (AREA)

Abstract

1-N-(alpha-hydroxy-omega-aminoalkanoyl)-6'-N-methyl-3',4'-dideoxyka namycins B or pharmaceutically acceptable acid addition salts thereof are prepared by selective acylation of the 1-amino group of an amino-protected derivative of the formula <IMAGE> in which R1 is a monovalent amino protective group and R2 is hydrogen or a monovalent amino protective group, with an alpha -hydroxyomega -amino acid of the formula V or with a functional derivative thereof, in which n is 1, 2 or 3, R3 is an amino protective group and R4 is hydrogen, or R3 and R4 together are a divalent amino protective group, after which the amino protective groups are eliminated from the 1-N-acylated product obtained in this way. The prepared compounds are effective not only against Gram-negative and Gram-positive bacteria with the usual kanamycin sensitivity but also against kanamycin-resistant bacteria. <IMAGE>
SE7511229A 1974-10-08 1975-10-07 PROCEDURE FOR THE PREPARATION OF 1N- (ALFA-HYDROXY-OMEGA-AMINO-ALKANOYL) -6 721N-METHYL-3 721, 4 721-DIDEOXICANAMYCINE B OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS. SE431216B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP49115199A JPS5148634A (en) 1974-10-08 1974-10-08 Taiseikinnyukona 11nn * arufua hidorokishi omega aminoashiru * 6**nn mechiru 3* *hh jideokishikanamaishin b no seizoho

Publications (2)

Publication Number Publication Date
SE7511229L true SE7511229L (en) 1976-04-09
SE431216B SE431216B (en) 1984-01-23

Family

ID=14656799

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7511229A SE431216B (en) 1974-10-08 1975-10-07 PROCEDURE FOR THE PREPARATION OF 1N- (ALFA-HYDROXY-OMEGA-AMINO-ALKANOYL) -6 721N-METHYL-3 721, 4 721-DIDEOXICANAMYCINE B OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS.

Country Status (16)

Country Link
JP (1) JPS5148634A (en)
BE (1) BE834236A (en)
CA (1) CA1050537A (en)
CH (1) CH615685A5 (en)
DE (1) DE2543535C3 (en)
DK (1) DK148262C (en)
FR (1) FR2287233A1 (en)
GB (1) GB1475481A (en)
HU (1) HU173702B (en)
IE (1) IE42354B1 (en)
LU (1) LU73533A1 (en)
NL (1) NL181503C (en)
SE (1) SE431216B (en)
SU (1) SU965359A3 (en)
YU (1) YU39659B (en)
ZA (1) ZA756291B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57175198A (en) * 1981-04-20 1982-10-28 Microbial Chem Res Found 1-n-acyl derivative of 5,3,4-trideoxy-6-n-methylkanamycin b and their preparation
JPS60179468U (en) * 1984-05-11 1985-11-28 大成プラス株式会社 multicolor stamp
DE102006004062A1 (en) 2006-01-28 2007-08-09 Degussa Gmbh rubber compounds
RU2458931C2 (en) 2006-06-02 2012-08-20 Мейдзи Сейка Фарма Ко., Лтд. New aminoglycoside antibiotics

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4001208A (en) * 1972-10-06 1977-01-04 Zaidan Hojin Biseibutsu Kagaku Kenkyo Kai 1-N-[(S)-α-hydroxy-ω-aminoacyl]

Also Published As

Publication number Publication date
NL7511662A (en) 1976-04-12
YU39659B (en) 1985-03-20
DE2543535B2 (en) 1977-10-13
AU8518975A (en) 1977-03-31
DE2543535A1 (en) 1976-04-22
IE42354L (en) 1976-04-08
FR2287233A1 (en) 1976-05-07
DE2543535C3 (en) 1978-06-01
CA1050537A (en) 1979-03-13
JPS5653558B2 (en) 1981-12-19
YU253075A (en) 1982-05-31
SU965359A3 (en) 1982-10-07
ZA756291B (en) 1976-06-30
SE431216B (en) 1984-01-23
IE42354B1 (en) 1980-07-30
NL181503C (en) 1987-09-01
DK148262B (en) 1985-05-20
FR2287233B1 (en) 1978-11-10
LU73533A1 (en) 1976-08-19
DK148262C (en) 1986-02-10
GB1475481A (en) 1977-06-01
NL181503B (en) 1987-04-01
DK451475A (en) 1976-04-09
CH615685A5 (en) 1980-02-15
HU173702B (en) 1979-07-28
BE834236A (en) 1976-04-06
JPS5148634A (en) 1976-04-26

Similar Documents

Publication Publication Date Title
ES464772A1 (en) Thiazolylacetamido cephalosporin type compounds
ES454118A1 (en) Glucosamine derivatives and a process for their manufacture
ES2137162T3 (en) CEPHALOSPORINS AND APPROVALS, PHARMACEUTICAL PREPARATIONS AND COMPOSITIONS.
GB1426908A (en) 1-n--s--alpha-hydroxy-omega-aminoacyl- derivative of amino glycosidic antibiotics
GB1529243A (en) Process for the preparation of aminoglycoside derivatives and cyclic urethane intermediates for use therein
GB1530201A (en) Process for the preparation of aminoglycoside antibiotics and intermediates therefor
JPS5543011A (en) 7-halothiazolylalkoxyiminoacetamido-3-cephem compound
SE7511229L (en) ANTIQUE BACTERIAL AGENT
SE7612964L (en) TIENAMYCIN DERIVATIVES
GB1521073A (en) Cephalosporin compounds
GB1535215A (en) Kanamycin derivatives
ES469303A1 (en) Process for the preparation of kanamycin derivatives
ES403973A1 (en) (ile3,leu4)-vasopressin analogs and intermediates
GB1317275A (en) Process for the preparation of n-protected-alpha-l-glutamyl-s benzyl-l-cysteinylglycines
ES432862A1 (en) Antibiotic derivatives of xk-62-2 and method of production thereof
ES8506749A1 (en) 1N-(omega-amino-alpha-hydroxyalkanoyl)-2&#39;,3&#39;-dideoxykanamycin A and the production of the same.
JPS55329A (en) Novel xk-62-4 derivative
FR2435481B1 (en)
ES8304973A1 (en) Beta-lactam antibiotics, their preparation and use.
ES435375A1 (en) Derivative of antibiotic xk-62-2 and method of production thereof
ES444643A1 (en) Bacterial culture medium
GB1352870A (en) Photosensitive compositions
SE7709646L (en) ANTIBACTERIAL AGENTS
ES404747A1 (en) Derivatives of kanamycin a and b and a process for the preparation thereof
SE7612960L (en) TIENAMYCIN DERIVATIVES

Legal Events

Date Code Title Description
NUG Patent has lapsed

Ref document number: 7511229-2

Effective date: 19930510

Format of ref document f/p: F