SE7612960L - TIENAMYCIN DERIVATIVES - Google Patents

TIENAMYCIN DERIVATIVES

Info

Publication number
SE7612960L
SE7612960L SE7612960A SE7612960A SE7612960L SE 7612960 L SE7612960 L SE 7612960L SE 7612960 A SE7612960 A SE 7612960A SE 7612960 A SE7612960 A SE 7612960A SE 7612960 L SE7612960 L SE 7612960L
Authority
SE
Sweden
Prior art keywords
hydrogen
pharmaceutically acceptable
acceptable salts
acyl
derivatives
Prior art date
Application number
SE7612960A
Other languages
Swedish (sv)
Other versions
SE427840B (en
Inventor
L Barash
B G Christensen
W J Leanza
J Hannah
D H-M Shih
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of SE7612960L publication Critical patent/SE7612960L/en
Publication of SE427840B publication Critical patent/SE427840B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Abstract

N-Acyl derivatives and phosphorus-containing N-acyl derivatives of the antibiotic thienamycin of the general formula (II) <IMAGE> in which R<1> and R<2>, independently of each other, are selected from hydrogen, acyl and phosphorus-containing acyl, with the proviso that R<1> and R<2> are not both hydrogen and that, when R<1> or R<2> denotes acetyl, R<2> or R<1> is different from hydrogen and their non-toxic, pharmaceutically acceptable salts, are obtained by treating thienamycin with an appropriate acylating agent and converting the resulting compounds of the formula (II), where appropriate, into their non-toxic, pharmaceutically acceptable salts. The compounds which are obtained, and their pharmaceutically acceptable salts, are suitable for use as antibiotics.
SE7612960A 1975-11-21 1976-11-19 ANALOGY PROCEDURE FOR THE PREPARATION OF TIENAMYCIN DERIVATIVES SE427840B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63429175A 1975-11-21 1975-11-21

Publications (2)

Publication Number Publication Date
SE7612960L true SE7612960L (en) 1977-05-22
SE427840B SE427840B (en) 1983-05-09

Family

ID=24543192

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7612960A SE427840B (en) 1975-11-21 1976-11-19 ANALOGY PROCEDURE FOR THE PREPARATION OF TIENAMYCIN DERIVATIVES

Country Status (8)

Country Link
JP (1) JPS5277083A (en)
CH (1) CH632509A5 (en)
DE (1) DE2652675A1 (en)
DK (1) DK523276A (en)
FR (1) FR2332016A1 (en)
GB (1) GB1570986A (en)
NL (1) NL189298C (en)
SE (1) SE427840B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0008888B1 (en) * 1978-08-23 1983-09-21 Beecham Group Plc Beta-lactam antibacterial compounds, their preparation and pharmaceutical compositions containing them
DK456580A (en) * 1979-10-29 1981-06-04 Beecham Group Ltd PROCEDURE FOR PREPARING BICYCLIC BETA-LACTAMRING COMPOUNDS
EP0044142A1 (en) * 1980-07-03 1982-01-20 Beecham Group Plc Process for the preparation of beta-lactam antibiotics
WO2017132321A1 (en) * 2016-01-29 2017-08-03 The Johns Hopkins University Novel inhibitors of bacterial growth

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1004670A (en) * 1963-04-23 1965-09-15 Beecham Res Lab Penicillins
GB1348985A (en) * 1970-06-16 1974-03-27 Merck & Co Inc Esters of cephalosporin compounds

Also Published As

Publication number Publication date
FR2332016B1 (en) 1978-11-10
NL7612940A (en) 1977-05-24
GB1570986A (en) 1980-07-09
SE427840B (en) 1983-05-09
JPS5277083A (en) 1977-06-29
CH632509A5 (en) 1982-10-15
DE2652675C2 (en) 1990-02-01
FR2332016A1 (en) 1977-06-17
DE2652675A1 (en) 1977-06-02
JPS61346B2 (en) 1986-01-08
NL189298B (en) 1992-10-01
DK523276A (en) 1977-05-22
NL189298C (en) 1993-03-01

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