SE7709646L - ANTIBACTERIAL AGENTS - Google Patents

ANTIBACTERIAL AGENTS

Info

Publication number
SE7709646L
SE7709646L SE7709646A SE7709646A SE7709646L SE 7709646 L SE7709646 L SE 7709646L SE 7709646 A SE7709646 A SE 7709646A SE 7709646 A SE7709646 A SE 7709646A SE 7709646 L SE7709646 L SE 7709646L
Authority
SE
Sweden
Prior art keywords
reaction
cephalosporin
appropriate
antibacterial agents
infections
Prior art date
Application number
SE7709646A
Other languages
Swedish (sv)
Inventor
W J Gottstein
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of SE7709646L publication Critical patent/SE7709646L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C265/00—Derivatives of isocyanic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cephalosporins of the formula I in which R<1> represents alkyl having 1 - 4 C atoms and n is 1, 2 or 3, and non-toxic, pharmaceutically utilisable salts and esters thereof are obtained by reaction of an appropriate cephalosporin, which carries an acetoxymethyl group in the 3-position of the ring system, with an appropriate mercaptotetrazole compound. In an alternative process, this reaction is carried out using a cephalosporin having a free amino group, this being appropriately acylated in a second step. The compounds can be used in pharmaceutical compositions for the control of bacterial infections, such as Haemophilus or Neisseria infections. <IMAGE>
SE7709646A 1976-08-30 1977-08-29 ANTIBACTERIAL AGENTS SE7709646L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71902576A 1976-08-30 1976-08-30

Publications (1)

Publication Number Publication Date
SE7709646L true SE7709646L (en) 1978-03-01

Family

ID=24888488

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7709646A SE7709646L (en) 1976-08-30 1977-08-29 ANTIBACTERIAL AGENTS

Country Status (18)

Country Link
JP (1) JPS5331693A (en)
AU (1) AU510280B2 (en)
BE (1) BE858112A (en)
CA (1) CA1115267A (en)
CH (1) CH638812A5 (en)
DE (1) DE2739080A1 (en)
DK (1) DK382977A (en)
ES (1) ES461983A1 (en)
FI (1) FI64803C (en)
FR (1) FR2372167A1 (en)
GB (1) GB1557423A (en)
GR (1) GR74023B (en)
IE (1) IE46431B1 (en)
LU (1) LU78027A1 (en)
NL (1) NL7709466A (en)
SE (1) SE7709646L (en)
YU (1) YU204877A (en)
ZA (1) ZA775193B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2421907A1 (en) * 1978-04-07 1979-11-02 Roussel Uclaf NEW CEPHALOSPORINS DERIVED FROM 7- / 2- (2-AMINO 4-THIAZOLYL) 2- (CARBOXYMETHOXYIMINO / ACETAMIDO 3-SUBSTITUTE CEPHALOSPORANIC ACID, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS
FI782683A (en) * 1978-07-19 1980-01-20 Hoffmann La Roche KEFALOSPORINESTRAR OCH -ESTRAR
US4973107A (en) * 1989-11-01 1990-11-27 Graham John M Dual pressure air brake system
JP2004538265A (en) * 2001-04-19 2004-12-24 ビオフェルマ ムルシア，エス．アー． Method for producing 3-cephalosporanic acid derivative using α-keto acid derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4286089A (en) * 1974-12-27 1981-08-25 Smithkline Corporation 7-Acyl-3-(substituted tetrazolyl thiomethyl)cephalosporins
NZ182649A (en) * 1975-11-27 1979-11-01 Beecham Group Ltd Cephalosporins,intermediates, and phrmaceutical compositions
US4278670A (en) * 1976-07-12 1981-07-14 Smithkline Corporation 7-Alpha-oxyiminoacylcephalosporins

Also Published As

Publication number Publication date
FI64803C (en) 1984-01-10
ZA775193B (en) 1978-07-26
CH638812A5 (en) 1983-10-14
JPS5331693A (en) 1978-03-25
FI64803B (en) 1983-09-30
DK382977A (en) 1978-03-01
NL7709466A (en) 1978-03-02
AU2797277A (en) 1979-02-22
GR74023B (en) 1984-06-06
FI772549A (en) 1978-03-01
IE46431B1 (en) 1983-06-15
CA1115267A (en) 1981-12-29
ES461983A1 (en) 1978-12-01
IE771799L (en) 1978-02-28
DE2739080A1 (en) 1978-03-02
YU204877A (en) 1982-10-31
FR2372167A1 (en) 1978-06-23
GB1557423A (en) 1979-12-12
AU510280B2 (en) 1980-06-19
BE858112A (en) 1978-02-27
FR2372167B1 (en) 1981-11-27
LU78027A1 (en) 1978-04-27

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