GB1557423A - Cephalosporins - Google Patents
CephalosporinsInfo
- Publication number
- GB1557423A GB1557423A GB35958/77A GB3595877A GB1557423A GB 1557423 A GB1557423 A GB 1557423A GB 35958/77 A GB35958/77 A GB 35958/77A GB 3595877 A GB3595877 A GB 3595877A GB 1557423 A GB1557423 A GB 1557423A
- Authority
- GB
- United Kingdom
- Prior art keywords
- reaction
- cephalosporin
- appropriate
- cephalosporins
- infections
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C265/00—Derivatives of isocyanic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Cephalosporins of the formula I in which R<1> represents alkyl having 1 - 4 C atoms and n is 1, 2 or 3, and non-toxic, pharmaceutically utilisable salts and esters thereof are obtained by reaction of an appropriate cephalosporin, which carries an acetoxymethyl group in the 3-position of the ring system, with an appropriate mercaptotetrazole compound. In an alternative process, this reaction is carried out using a cephalosporin having a free amino group, this being appropriately acylated in a second step. The compounds can be used in pharmaceutical compositions for the control of bacterial infections, such as Haemophilus or Neisseria infections. <IMAGE>
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71902576A | 1976-08-30 | 1976-08-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1557423A true GB1557423A (en) | 1979-12-12 |
Family
ID=24888488
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB35958/77A Expired GB1557423A (en) | 1976-08-30 | 1977-08-26 | Cephalosporins |
Country Status (18)
Country | Link |
---|---|
JP (1) | JPS5331693A (en) |
AU (1) | AU510280B2 (en) |
BE (1) | BE858112A (en) |
CA (1) | CA1115267A (en) |
CH (1) | CH638812A5 (en) |
DE (1) | DE2739080A1 (en) |
DK (1) | DK382977A (en) |
ES (1) | ES461983A1 (en) |
FI (1) | FI64803C (en) |
FR (1) | FR2372167A1 (en) |
GB (1) | GB1557423A (en) |
GR (1) | GR74023B (en) |
IE (1) | IE46431B1 (en) |
LU (1) | LU78027A1 (en) |
NL (1) | NL7709466A (en) |
SE (1) | SE7709646L (en) |
YU (1) | YU204877A (en) |
ZA (1) | ZA775193B (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2421907A1 (en) * | 1978-04-07 | 1979-11-02 | Roussel Uclaf | NEW CEPHALOSPORINS DERIVED FROM 7- / 2- (2-AMINO 4-THIAZOLYL) 2- (CARBOXYMETHOXYIMINO / ACETAMIDO 3-SUBSTITUTE CEPHALOSPORANIC ACID, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
FI782683A (en) * | 1978-07-19 | 1980-01-20 | Hoffmann La Roche | KEFALOSPORINESTRAR OCH -ESTRAR |
US4973107A (en) * | 1989-11-01 | 1990-11-27 | Graham John M | Dual pressure air brake system |
EP1379531A2 (en) * | 2001-04-19 | 2004-01-14 | Bioferma Murcia, S.A. | Enzymatic process for preparing cephalosporanic acid derivatives using alpha-ketoacid derivatives |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4286089A (en) * | 1974-12-27 | 1981-08-25 | Smithkline Corporation | 7-Acyl-3-(substituted tetrazolyl thiomethyl)cephalosporins |
NZ182649A (en) * | 1975-11-27 | 1979-11-01 | Beecham Group Ltd | Cephalosporins,intermediates, and phrmaceutical compositions |
US4278670A (en) * | 1976-07-12 | 1981-07-14 | Smithkline Corporation | 7-Alpha-oxyiminoacylcephalosporins |
-
1977
- 1977-08-17 CA CA284,873A patent/CA1115267A/en not_active Expired
- 1977-08-17 AU AU27972/77A patent/AU510280B2/en not_active Expired
- 1977-08-19 GR GR54196A patent/GR74023B/el unknown
- 1977-08-25 BE BE180434A patent/BE858112A/en not_active IP Right Cessation
- 1977-08-25 LU LU78027A patent/LU78027A1/xx unknown
- 1977-08-26 ZA ZA00775193A patent/ZA775193B/en unknown
- 1977-08-26 GB GB35958/77A patent/GB1557423A/en not_active Expired
- 1977-08-26 NL NL7709466A patent/NL7709466A/en not_active Application Discontinuation
- 1977-08-26 FI FI772549A patent/FI64803C/en not_active IP Right Cessation
- 1977-08-29 SE SE7709646A patent/SE7709646L/en not_active Application Discontinuation
- 1977-08-29 IE IE1799/77A patent/IE46431B1/en unknown
- 1977-08-29 YU YU02048/77A patent/YU204877A/en unknown
- 1977-08-29 CH CH1051577A patent/CH638812A5/en not_active IP Right Cessation
- 1977-08-29 DK DK382977A patent/DK382977A/en not_active Application Discontinuation
- 1977-08-30 FR FR7726395A patent/FR2372167A1/en active Granted
- 1977-08-30 JP JP10329877A patent/JPS5331693A/en active Pending
- 1977-08-30 DE DE19772739080 patent/DE2739080A1/en not_active Withdrawn
- 1977-08-30 ES ES461983A patent/ES461983A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
FI64803C (en) | 1984-01-10 |
NL7709466A (en) | 1978-03-02 |
DK382977A (en) | 1978-03-01 |
IE771799L (en) | 1978-02-28 |
BE858112A (en) | 1978-02-27 |
IE46431B1 (en) | 1983-06-15 |
FR2372167B1 (en) | 1981-11-27 |
AU510280B2 (en) | 1980-06-19 |
DE2739080A1 (en) | 1978-03-02 |
JPS5331693A (en) | 1978-03-25 |
FI772549A (en) | 1978-03-01 |
CH638812A5 (en) | 1983-10-14 |
ES461983A1 (en) | 1978-12-01 |
CA1115267A (en) | 1981-12-29 |
AU2797277A (en) | 1979-02-22 |
FR2372167A1 (en) | 1978-06-23 |
GR74023B (en) | 1984-06-06 |
YU204877A (en) | 1982-10-31 |
ZA775193B (en) | 1978-07-26 |
SE7709646L (en) | 1978-03-01 |
FI64803B (en) | 1983-09-30 |
LU78027A1 (en) | 1978-04-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |