GB1557423A - Cephalosporins - Google Patents

Cephalosporins

Info

Publication number
GB1557423A
GB1557423A GB35958/77A GB3595877A GB1557423A GB 1557423 A GB1557423 A GB 1557423A GB 35958/77 A GB35958/77 A GB 35958/77A GB 3595877 A GB3595877 A GB 3595877A GB 1557423 A GB1557423 A GB 1557423A
Authority
GB
United Kingdom
Prior art keywords
reaction
cephalosporin
appropriate
cephalosporins
infections
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB35958/77A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of GB1557423A publication Critical patent/GB1557423A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04Five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C265/00Derivatives of isocyanic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/207-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/247-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36Methylene radicals, substituted by sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cephalosporins of the formula I in which R<1> represents alkyl having 1 - 4 C atoms and n is 1, 2 or 3, and non-toxic, pharmaceutically utilisable salts and esters thereof are obtained by reaction of an appropriate cephalosporin, which carries an acetoxymethyl group in the 3-position of the ring system, with an appropriate mercaptotetrazole compound. In an alternative process, this reaction is carried out using a cephalosporin having a free amino group, this being appropriately acylated in a second step. The compounds can be used in pharmaceutical compositions for the control of bacterial infections, such as Haemophilus or Neisseria infections. <IMAGE>
GB35958/77A 1976-08-30 1977-08-26 Cephalosporins Expired GB1557423A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71902576A 1976-08-30 1976-08-30

Publications (1)

Publication Number Publication Date
GB1557423A true GB1557423A (en) 1979-12-12

Family

ID=24888488

Family Applications (1)

Application Number Title Priority Date Filing Date
GB35958/77A Expired GB1557423A (en) 1976-08-30 1977-08-26 Cephalosporins

Country Status (18)

Country Link
JP (1) JPS5331693A (en)
AU (1) AU510280B2 (en)
BE (1) BE858112A (en)
CA (1) CA1115267A (en)
CH (1) CH638812A5 (en)
DE (1) DE2739080A1 (en)
DK (1) DK382977A (en)
ES (1) ES461983A1 (en)
FI (1) FI64803C (en)
FR (1) FR2372167A1 (en)
GB (1) GB1557423A (en)
GR (1) GR74023B (en)
IE (1) IE46431B1 (en)
LU (1) LU78027A1 (en)
NL (1) NL7709466A (en)
SE (1) SE7709646L (en)
YU (1) YU204877A (en)
ZA (1) ZA775193B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2421907A1 (en) * 1978-04-07 1979-11-02 Roussel Uclaf NEW CEPHALOSPORINS DERIVED FROM 7- / 2- (2-AMINO 4-THIAZOLYL) 2- (CARBOXYMETHOXYIMINO / ACETAMIDO 3-SUBSTITUTE CEPHALOSPORANIC ACID, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS
FI782683A (en) * 1978-07-19 1980-01-20 Hoffmann La Roche KEFALOSPORINESTRAR OCH -ESTRAR
US4973107A (en) * 1989-11-01 1990-11-27 Graham John M Dual pressure air brake system
EP1379531A2 (en) * 2001-04-19 2004-01-14 Bioferma Murcia, S.A. Enzymatic process for preparing cephalosporanic acid derivatives using alpha-ketoacid derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4286089A (en) * 1974-12-27 1981-08-25 Smithkline Corporation 7-Acyl-3-(substituted tetrazolyl thiomethyl)cephalosporins
NZ182649A (en) * 1975-11-27 1979-11-01 Beecham Group Ltd Cephalosporins,intermediates, and phrmaceutical compositions
US4278670A (en) * 1976-07-12 1981-07-14 Smithkline Corporation 7-Alpha-oxyiminoacylcephalosporins

Also Published As

Publication number Publication date
FI64803C (en) 1984-01-10
NL7709466A (en) 1978-03-02
DK382977A (en) 1978-03-01
IE771799L (en) 1978-02-28
BE858112A (en) 1978-02-27
IE46431B1 (en) 1983-06-15
FR2372167B1 (en) 1981-11-27
AU510280B2 (en) 1980-06-19
DE2739080A1 (en) 1978-03-02
JPS5331693A (en) 1978-03-25
FI772549A (en) 1978-03-01
CH638812A5 (en) 1983-10-14
ES461983A1 (en) 1978-12-01
CA1115267A (en) 1981-12-29
AU2797277A (en) 1979-02-22
FR2372167A1 (en) 1978-06-23
GR74023B (en) 1984-06-06
YU204877A (en) 1982-10-31
ZA775193B (en) 1978-07-26
SE7709646L (en) 1978-03-01
FI64803B (en) 1983-09-30
LU78027A1 (en) 1978-04-27

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee