NL7505473A - PROCEDURE FOR PREPARING PYROGLUTAMYL COMPOUNDS WITH ANTI-PRESSURE ACTION. - Google Patents

PROCEDURE FOR PREPARING PYROGLUTAMYL COMPOUNDS WITH ANTI-PRESSURE ACTION.

Info

Publication number
NL7505473A
NL7505473A NL7505473A NL7505473A NL7505473A NL 7505473 A NL7505473 A NL 7505473A NL 7505473 A NL7505473 A NL 7505473A NL 7505473 A NL7505473 A NL 7505473A NL 7505473 A NL7505473 A NL 7505473A
Authority
NL
Netherlands
Prior art keywords
compounds
pyroglutamyl
preparing
procedure
group
Prior art date
Application number
NL7505473A
Other languages
Dutch (nl)
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NL7505473A publication Critical patent/NL7505473A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06173—Dipeptides with the first amino acid being heterocyclic and Glp-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Novel pyroglutamyl compounds of the formula I <IMAGE> in which X denotes an optionally branched alkyl radical having 2 to 6 carbon atoms or an optionally branched alkyl radical having 2 to 6 carbon atoms which is either substituted in the alpha -position by a carbamoyl group or in the omega -position by a carbamoyl group or a carboxyl group, are prepared by reaction of a pyroglutamic acid, which is optionally substituted on the nitrogen by a benzyloxycarbonyl radical, or of a reactive derivative thereof with a primary amine which introduces the group X and subsequent removal of possible carboxyl protective groups. The novel compounds are useful therapeutics for the treatment of psychic disorders, in particular of depressions.
NL7505473A 1974-05-14 1975-05-09 PROCEDURE FOR PREPARING PYROGLUTAMYL COMPOUNDS WITH ANTI-PRESSURE ACTION. NL7505473A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2423390A DE2423390A1 (en) 1974-05-14 1974-05-14 PYROGLUTAMYL COMPOUNDS WITH ANTIDEPRESSIVE EFFECT AND PROCESS FOR THEIR PRODUCTION

Publications (1)

Publication Number Publication Date
NL7505473A true NL7505473A (en) 1975-11-18

Family

ID=5915523

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7505473A NL7505473A (en) 1974-05-14 1975-05-09 PROCEDURE FOR PREPARING PYROGLUTAMYL COMPOUNDS WITH ANTI-PRESSURE ACTION.

Country Status (14)

Country Link
JP (1) JPS50157362A (en)
AT (2) AT352707B (en)
BE (1) BE829059A (en)
CA (1) CA1064942A (en)
CH (2) CH613689A5 (en)
DE (1) DE2423390A1 (en)
DK (1) DK209575A (en)
FR (1) FR2270866B1 (en)
GB (1) GB1472154A (en)
IE (1) IE41145B1 (en)
IL (1) IL47258A (en)
LU (1) LU72450A1 (en)
NL (1) NL7505473A (en)
SE (1) SE405113B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840667A (en) * 1994-08-05 1998-11-24 Warwick International Group, Ltd. Bleach activators
EP1024134A4 (en) * 1997-10-09 2003-05-14 Ono Pharmaceutical Co Aminobutanoic acid derivatives
RU2232578C1 (en) * 2003-04-10 2004-07-20 Ахапкина Валентина Ивановна Substance eliciting antidepressant activity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5220996B2 (en) * 1972-01-14 1977-06-07
JPS5015793B2 (en) * 1972-06-07 1975-06-07

Also Published As

Publication number Publication date
IL47258A (en) 1978-07-31
FR2270866B1 (en) 1978-08-04
IL47258A0 (en) 1975-07-28
SE7505546L (en) 1975-11-17
SE405113B (en) 1978-11-20
IE41145B1 (en) 1979-10-24
IE41145L (en) 1975-11-14
JPS50157362A (en) 1975-12-19
DE2423390A1 (en) 1975-12-04
AT364875B (en) 1979-03-15
FR2270866A1 (en) 1975-12-12
ATA13179A (en) 1981-04-15
AT352707B (en) 1979-10-10
CH613689A5 (en) 1979-10-15
CH612180A5 (en) 1979-07-13
GB1472154A (en) 1977-05-04
LU72450A1 (en) 1977-02-09
ATA364875A (en) 1979-03-15
BE829059A (en) 1975-11-14
DK209575A (en) 1975-11-15
CA1064942A (en) 1979-10-23

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Legal Events

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BA A request for search or an international-type search has been filed
BB A search report has been drawn up
BC A request for examination has been filed
BV The patent application has lapsed