GB1482388A - Method of producing 6-beta-amidinopenicillanic acid derivatives - Google Patents
Method of producing 6-beta-amidinopenicillanic acid derivativesInfo
- Publication number
- GB1482388A GB1482388A GB27639/75A GB2763975A GB1482388A GB 1482388 A GB1482388 A GB 1482388A GB 27639/75 A GB27639/75 A GB 27639/75A GB 2763975 A GB2763975 A GB 2763975A GB 1482388 A GB1482388 A GB 1482388A
- Authority
- GB
- United Kingdom
- Prior art keywords
- beta
- acid derivatives
- reaction
- carried out
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
6 beta -Aminomethyleneaminopenicillanic acid derivatives of the following formula <IMAGE> are prepared, in which R<1> and R<2> are identical or different and unbranched or branched aliphatic hydrocarbon radicals or cycloaliphatic hydrocarbon radicals, where R<1> and R<2> may also form together with the nitrogen atom a heterocyclic radical; R<3> is H, alkyl, aralkyl or pivaloyloxymethyl. These compounds are obtained by reacting a corresponding 6-aminopenicillanic ester or trimethylsilyl 6-aminopenicillanate with an appropriate secondary amine. The reaction is carried out in the presence of a condensing agent selected from the group comprising orthoformates, thioorthoformates and 1,1-dichlorodimethyl ether. The reaction is carried out at -5 to +30 DEG C in an organic solvent medium. The resulting derivatives can be used as antibacterial agents.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU7502092903A SU566843A1 (en) | 1975-01-06 | 1975-01-06 | Method of preparing derivatives of 6- -amidino penicillanic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1482388A true GB1482388A (en) | 1977-08-10 |
Family
ID=20606315
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB27639/75A Expired GB1482388A (en) | 1975-01-06 | 1975-07-01 | Method of producing 6-beta-amidinopenicillanic acid derivatives |
Country Status (7)
Country | Link |
---|---|
JP (1) | JPS5210287A (en) |
CA (1) | CA1052771A (en) |
CH (1) | CH612974A5 (en) |
DE (1) | DE2530299A1 (en) |
FR (1) | FR2296638A1 (en) |
GB (1) | GB1482388A (en) |
SU (1) | SU566843A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4508723A (en) * | 1977-05-17 | 1985-04-02 | Ciba Geigy Corporation | 6-Azaoligocycloalkylmethyleneaminopenam compounds |
CN114573603A (en) * | 2022-03-07 | 2022-06-03 | 南京美智德合成材料有限公司 | Process for synthesizing pimecrcillin in one pot |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE758782A (en) * | 1969-11-11 | 1971-05-10 | Leo Pharm Prod Ltd | NEW DERIVATIVES OF 6-AMIDINO PENICILLANIC ACID, THEIR PREPARATION PROCESS AND THEIR APPLICATIONS AS ANTIBIOTICS |
GB1427139A (en) * | 1972-03-13 | 1976-03-10 | Astra Laekemedel Ab | Penicillins |
GB1417099A (en) * | 1973-02-02 | 1975-12-10 | Leo Pharm Prod Ltd | Method for the production of derivatives of 6-aminopenicillanic acid |
-
1975
- 1975-01-06 SU SU7502092903A patent/SU566843A1/en active
- 1975-06-30 CA CA230,488A patent/CA1052771A/en not_active Expired
- 1975-07-01 GB GB27639/75A patent/GB1482388A/en not_active Expired
- 1975-07-07 DE DE19752530299 patent/DE2530299A1/en active Pending
- 1975-07-09 JP JP50083616A patent/JPS5210287A/en active Granted
- 1975-07-24 CH CH968675A patent/CH612974A5/en not_active IP Right Cessation
- 1975-10-06 FR FR7530540A patent/FR2296638A1/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4508723A (en) * | 1977-05-17 | 1985-04-02 | Ciba Geigy Corporation | 6-Azaoligocycloalkylmethyleneaminopenam compounds |
CN114573603A (en) * | 2022-03-07 | 2022-06-03 | 南京美智德合成材料有限公司 | Process for synthesizing pimecrcillin in one pot |
Also Published As
Publication number | Publication date |
---|---|
CH612974A5 (en) | 1979-08-31 |
JPS5210287A (en) | 1977-01-26 |
SU566843A1 (en) | 1977-07-30 |
FR2296638A1 (en) | 1976-07-30 |
JPS5417756B2 (en) | 1979-07-02 |
CA1052771A (en) | 1979-04-17 |
FR2296638B1 (en) | 1978-04-07 |
DE2530299A1 (en) | 1976-07-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3363244D1 (en) | Compounds, process for their preparation and their use as pharmaceutical preparations | |
ES477695A1 (en) | Derivatives of dehydrocyclicimino acids | |
JPS5517386A (en) | Novel oxadiazolopyrimidine derivative | |
ES443912A1 (en) | Phenylacetic acid derivatives | |
SE7909017L (en) | SET TO PREPARE 1,2,3-THIADIAZOL-5-YL CARBAMIDES | |
GB1482388A (en) | Method of producing 6-beta-amidinopenicillanic acid derivatives | |
GB2017087A (en) | Process for the preparation of xanthone derivatives | |
GB1524727A (en) | Aliphatic sulphamates | |
JPS54128591A (en) | Cephalosporin analog | |
GB1047061A (en) | Polymers and a process for the preparation thereof | |
SE8301785L (en) | SET TO MAKE 2-THIOPHENIC ACETIC ACID DERIVATIVES AND INTERMEDIATES REQUIRED FOR THEIR PREPARATION | |
SE7603640L (en) | METHOD OF PRODUCTION OF INDEPENDENT, BIOLOGICALLY ACTIVE ASSOCIATIONS | |
SE7811761L (en) | 4,5,6,7-TETRAHYDROIMIDAZO- (4,5-C), PYRIDINE DERIVATIVES AND PROCEDURE FOR THEIR PREPARATION | |
JPS5221392A (en) | Process for preparing prostaglandin derivatives | |
GB2017689A (en) | Substituted N- Iminomethylpiperidines | |
JPS5612395A (en) | Oxazolinoazetidinone derivative | |
ES485801A1 (en) | Process for preparing cyclo-1,3,2-oxazaphosphoryl derivatives | |
SE7905060L (en) | NEW 1-PYRROLE AND 1-PYRROLIDINE CARBOXYLIC ACID DERIVATIVES AND METHODS OF PREPARATION | |
CH608797A5 (en) | Process for the preparation of heterocyclic compounds | |
JPS51127068A (en) | A process for preparing 8-azaprostanoic acid derivatives. | |
ATE6654T1 (en) | SOLUTIONS OF SODIUM ALKYLENES IN HYDROCARBONS AND PROCESSES FOR THE PREPARATION OF THESE SOLUTIONS. | |
ES454265A1 (en) | Method for preparing novel cephalosporins | |
JPS5416466A (en) | Novel 3-hydroxypyrrolldine-3-carboxylic derivative | |
SE8105338L (en) | NEW SET TO MAKE APOVINCAMIC ACID ESTERS | |
GB2050380B (en) | Phosphorus containing compounds used in the preparation of cephalosporins |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |