GB1524727A - Aliphatic sulphamates - Google Patents

Aliphatic sulphamates

Info

Publication number
GB1524727A
GB1524727A GB48763/75A GB4876375A GB1524727A GB 1524727 A GB1524727 A GB 1524727A GB 48763/75 A GB48763/75 A GB 48763/75A GB 4876375 A GB4876375 A GB 4876375A GB 1524727 A GB1524727 A GB 1524727A
Authority
GB
United Kingdom
Prior art keywords
radicals
formula
compounds
reacting
aralkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB48763/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/537,613 external-priority patent/US3997585A/en
Priority claimed from US05/618,998 external-priority patent/US4061663A/en
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Publication of GB1524727A publication Critical patent/GB1524727A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/02—Monoamides of sulfuric acids or esters thereof, e.g. sulfamic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Bis-O-sulphamylglycols of the general formula I <IMAGE> are prepared by reacting a glycol of the formula II <IMAGE> with a sulphamyl chloride of the formula III (Hal)-SO2NR1R2 (III> in a solvent in the presence of a strong base. In these compounds, n is zero or an integer from 1 to 8, X and Y denote hydrogen, and if n is 1 additionally denotes lower alkyl radicals, aryl radicals, aralkyl radicals or cyclohexyl radicals. R1 and R2, independently of one another, are hydrogen atoms, alkyl, aryl, aralkyl or cycloalkyl radicals, or they form, together with the nitrogen atom to which they are bonded, a pyrrolidinyl ring or piperidinyl ring. Those compounds of the formula I in which all the radicals R1 and R2 are hydrogen atoms are also prepared by reacting a sulphamoyl halide of the formula III carrying a protective group on its nitrogen atom and, after the reaction, removing this protective group using an acid. The compounds of the formula I are suitable for regulation of the fertility of male animals.
GB48763/75A 1974-12-30 1975-11-27 Aliphatic sulphamates Expired GB1524727A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/537,613 US3997585A (en) 1974-12-30 1974-12-30 Aliphatic sulfamates
US05/618,998 US4061663A (en) 1975-10-02 1975-10-02 Process for preparation of aliphatic primary sulfamates

Publications (1)

Publication Number Publication Date
GB1524727A true GB1524727A (en) 1978-09-13

Family

ID=27065556

Family Applications (1)

Application Number Title Priority Date Filing Date
GB48763/75A Expired GB1524727A (en) 1974-12-30 1975-11-27 Aliphatic sulphamates

Country Status (11)

Country Link
JP (1) JPS5198217A (en)
AT (1) AT357998B (en)
CA (1) CA1082194A (en)
CH (1) CH617184A5 (en)
DE (1) DE2559210A1 (en)
DK (1) DK579975A (en)
FR (1) FR2296410A1 (en)
GB (1) GB1524727A (en)
NL (1) NL7514794A (en)
NO (1) NO141607C (en)
SE (1) SE7514459L (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997016417A1 (en) * 1995-11-02 1997-05-09 Yukong Limited Novel sulfamate compound containing carbamoyl group
WO1997016418A1 (en) * 1995-11-02 1997-05-09 Yukong Limited Novel sulfamate compound containing n-substituted carbamoyl group and method for preparing the same
US6476011B1 (en) 1991-08-28 2002-11-05 Sterix Limited Methods for introducing an estrogenic compound
US6903084B2 (en) 1991-08-29 2005-06-07 Sterix Limited Steroid sulphatase inhibitors
US7335650B2 (en) 2000-01-14 2008-02-26 Sterix Limited Composition

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT94305B (en) * 1989-06-12 1997-02-28 Robins Co Inc A H METHOD FOR PREPARING COMPOUNDS HAVING ONE OR MORE USED AMINOSULFONYLOXIDE RADIATIONS AS PHARMACEUTICAL PRODUCTS
US5273993A (en) * 1989-06-12 1993-12-28 A. H. Robins Company, Incorporated Compounds having one or more aminosulfonyloxy radicals useful as pharmaceuticals
US5194446A (en) * 1989-06-12 1993-03-16 A. H. Robins Company, Incorporated Compounds having one or more aminosulfaonyloxy radicals useful as pharmaceuticals
US6011024A (en) 1991-08-28 2000-01-04 Imperial College Of Science Technology & Medicine Steroid sulphatase inhibitors

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6476011B1 (en) 1991-08-28 2002-11-05 Sterix Limited Methods for introducing an estrogenic compound
US6677325B2 (en) 1991-08-28 2004-01-13 Sterix Ltd. Steroid sulphatase inhibitors
US6903084B2 (en) 1991-08-29 2005-06-07 Sterix Limited Steroid sulphatase inhibitors
WO1997016417A1 (en) * 1995-11-02 1997-05-09 Yukong Limited Novel sulfamate compound containing carbamoyl group
WO1997016418A1 (en) * 1995-11-02 1997-05-09 Yukong Limited Novel sulfamate compound containing n-substituted carbamoyl group and method for preparing the same
CN1077570C (en) * 1995-11-02 2002-01-09 Sk株式会社 Sulfamate compounds containing n -substituted carbanoyl and process for preparing the same
US7335650B2 (en) 2000-01-14 2008-02-26 Sterix Limited Composition

Also Published As

Publication number Publication date
FR2296410B1 (en) 1979-09-21
ATA986175A (en) 1980-01-15
NO754009L (en) 1976-07-01
AT357998B (en) 1980-08-11
FR2296410A1 (en) 1976-07-30
DK579975A (en) 1976-07-01
NL7514794A (en) 1976-07-02
SE7514459L (en) 1976-07-01
CH617184A5 (en) 1980-05-14
DE2559210A1 (en) 1976-07-01
CA1082194A (en) 1980-07-22
NO141607B (en) 1980-01-02
NO141607C (en) 1980-04-09
JPS5198217A (en) 1976-08-30

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee