IL47258A - Pyroglutamyl compounds having antidepressive activity and process for their manufacture - Google Patents

Pyroglutamyl compounds having antidepressive activity and process for their manufacture

Info

Publication number
IL47258A
IL47258A IL47258A IL4725875A IL47258A IL 47258 A IL47258 A IL 47258A IL 47258 A IL47258 A IL 47258A IL 4725875 A IL4725875 A IL 4725875A IL 47258 A IL47258 A IL 47258A
Authority
IL
Israel
Prior art keywords
compounds
pyroglutamyl
group
manufacture
carbon atoms
Prior art date
Application number
IL47258A
Other versions
IL47258A0 (en
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of IL47258A0 publication Critical patent/IL47258A0/en
Publication of IL47258A publication Critical patent/IL47258A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06173—Dipeptides with the first amino acid being heterocyclic and Glp-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Novel pyroglutamyl compounds of the formula I <IMAGE> in which X denotes an optionally branched alkyl radical having 2 to 6 carbon atoms or an optionally branched alkyl radical having 2 to 6 carbon atoms which is either substituted in the alpha -position by a carbamoyl group or in the omega -position by a carbamoyl group or a carboxyl group, are prepared by reaction of a pyroglutamic acid, which is optionally substituted on the nitrogen by a benzyloxycarbonyl radical, or of a reactive derivative thereof with a primary amine which introduces the group X and subsequent removal of possible carboxyl protective groups. The novel compounds are useful therapeutics for the treatment of psychic disorders, in particular of depressions.
IL47258A 1974-05-14 1975-05-08 Pyroglutamyl compounds having antidepressive activity and process for their manufacture IL47258A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2423390A DE2423390A1 (en) 1974-05-14 1974-05-14 PYROGLUTAMYL COMPOUNDS WITH ANTIDEPRESSIVE EFFECT AND PROCESS FOR THEIR PRODUCTION

Publications (2)

Publication Number Publication Date
IL47258A0 IL47258A0 (en) 1975-07-28
IL47258A true IL47258A (en) 1978-07-31

Family

ID=5915523

Family Applications (1)

Application Number Title Priority Date Filing Date
IL47258A IL47258A (en) 1974-05-14 1975-05-08 Pyroglutamyl compounds having antidepressive activity and process for their manufacture

Country Status (14)

Country Link
JP (1) JPS50157362A (en)
AT (2) AT352707B (en)
BE (1) BE829059A (en)
CA (1) CA1064942A (en)
CH (2) CH613689A5 (en)
DE (1) DE2423390A1 (en)
DK (1) DK209575A (en)
FR (1) FR2270866B1 (en)
GB (1) GB1472154A (en)
IE (1) IE41145B1 (en)
IL (1) IL47258A (en)
LU (1) LU72450A1 (en)
NL (1) NL7505473A (en)
SE (1) SE405113B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0775112A1 (en) * 1994-08-05 1997-05-28 Warwick International Group Limited Bleach activators
US6420427B1 (en) * 1997-10-09 2002-07-16 Ono Pharmaceutical Co., Ltd. Aminobutyric acid derivatives
RU2232578C1 (en) * 2003-04-10 2004-07-20 Ахапкина Валентина Ивановна Substance eliciting antidepressant activity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5220996B2 (en) * 1972-01-14 1977-06-07
JPS5015793B2 (en) * 1972-06-07 1975-06-07

Also Published As

Publication number Publication date
BE829059A (en) 1975-11-14
IL47258A0 (en) 1975-07-28
IE41145L (en) 1975-11-14
AT364875B (en) 1979-03-15
IE41145B1 (en) 1979-10-24
FR2270866B1 (en) 1978-08-04
ATA364875A (en) 1979-03-15
ATA13179A (en) 1981-04-15
NL7505473A (en) 1975-11-18
AT352707B (en) 1979-10-10
DK209575A (en) 1975-11-15
JPS50157362A (en) 1975-12-19
FR2270866A1 (en) 1975-12-12
CA1064942A (en) 1979-10-23
SE405113B (en) 1978-11-20
CH613689A5 (en) 1979-10-15
GB1472154A (en) 1977-05-04
LU72450A1 (en) 1977-02-09
CH612180A5 (en) 1979-07-13
SE7505546L (en) 1975-11-17
DE2423390A1 (en) 1975-12-04

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