GB1472154A - Pyroglutamyl compounds and process for their manufacture - Google Patents

Pyroglutamyl compounds and process for their manufacture

Info

Publication number
GB1472154A
GB1472154A GB1984075A GB1984075A GB1472154A GB 1472154 A GB1472154 A GB 1472154A GB 1984075 A GB1984075 A GB 1984075A GB 1984075 A GB1984075 A GB 1984075A GB 1472154 A GB1472154 A GB 1472154A
Authority
GB
United Kingdom
Prior art keywords
compounds
pyroglutamyl
group
carbon atoms
branched alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1984075A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of GB1472154A publication Critical patent/GB1472154A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06173—Dipeptides with the first amino acid being heterocyclic and Glp-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Novel pyroglutamyl compounds of the formula I <IMAGE> in which X denotes an optionally branched alkyl radical having 2 to 6 carbon atoms or an optionally branched alkyl radical having 2 to 6 carbon atoms which is either substituted in the alpha -position by a carbamoyl group or in the omega -position by a carbamoyl group or a carboxyl group, are prepared by reaction of a pyroglutamic acid, which is optionally substituted on the nitrogen by a benzyloxycarbonyl radical, or of a reactive derivative thereof with a primary amine which introduces the group X and subsequent removal of possible carboxyl protective groups. The novel compounds are useful therapeutics for the treatment of psychic disorders, in particular of depressions.
GB1984075A 1974-05-14 1975-05-12 Pyroglutamyl compounds and process for their manufacture Expired GB1472154A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2423390A DE2423390A1 (en) 1974-05-14 1974-05-14 PYROGLUTAMYL COMPOUNDS WITH ANTIDEPRESSIVE EFFECT AND PROCESS FOR THEIR PRODUCTION

Publications (1)

Publication Number Publication Date
GB1472154A true GB1472154A (en) 1977-05-04

Family

ID=5915523

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1984075A Expired GB1472154A (en) 1974-05-14 1975-05-12 Pyroglutamyl compounds and process for their manufacture

Country Status (14)

Country Link
JP (1) JPS50157362A (en)
AT (2) AT352707B (en)
BE (1) BE829059A (en)
CA (1) CA1064942A (en)
CH (2) CH612180A5 (en)
DE (1) DE2423390A1 (en)
DK (1) DK209575A (en)
FR (1) FR2270866B1 (en)
GB (1) GB1472154A (en)
IE (1) IE41145B1 (en)
IL (1) IL47258A (en)
LU (1) LU72450A1 (en)
NL (1) NL7505473A (en)
SE (1) SE405113B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840667A (en) * 1994-08-05 1998-11-24 Warwick International Group, Ltd. Bleach activators
WO2004089893A1 (en) * 2003-04-10 2004-10-21 Valentina Ivanovna Akhapkina Substance exhibiting antidepressant property

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6420427B1 (en) * 1997-10-09 2002-07-16 Ono Pharmaceutical Co., Ltd. Aminobutyric acid derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5220996B2 (en) * 1972-01-14 1977-06-07
JPS5015793B2 (en) * 1972-06-07 1975-06-07

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840667A (en) * 1994-08-05 1998-11-24 Warwick International Group, Ltd. Bleach activators
WO2004089893A1 (en) * 2003-04-10 2004-10-21 Valentina Ivanovna Akhapkina Substance exhibiting antidepressant property
EA009044B1 (en) * 2003-04-10 2007-10-26 Валентина Ивановна АХАПКИНА Substance inhibiting antidepressant property

Also Published As

Publication number Publication date
CH613689A5 (en) 1979-10-15
AT364875B (en) 1979-03-15
ATA364875A (en) 1979-03-15
SE405113B (en) 1978-11-20
AT352707B (en) 1979-10-10
DE2423390A1 (en) 1975-12-04
ATA13179A (en) 1981-04-15
SE7505546L (en) 1975-11-17
FR2270866B1 (en) 1978-08-04
JPS50157362A (en) 1975-12-19
NL7505473A (en) 1975-11-18
BE829059A (en) 1975-11-14
IE41145L (en) 1975-11-14
CA1064942A (en) 1979-10-23
IL47258A (en) 1978-07-31
CH612180A5 (en) 1979-07-13
IE41145B1 (en) 1979-10-24
DK209575A (en) 1975-11-15
IL47258A0 (en) 1975-07-28
LU72450A1 (en) 1977-02-09
FR2270866A1 (en) 1975-12-12

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee