ES470961A1 - Lipopeptides, process for their preparation and pharmaceutical compositions containing them. - Google Patents

Lipopeptides, process for their preparation and pharmaceutical compositions containing them.

Info

Publication number
ES470961A1
ES470961A1 ES470961A ES470961A ES470961A1 ES 470961 A1 ES470961 A1 ES 470961A1 ES 470961 A ES470961 A ES 470961A ES 470961 A ES470961 A ES 470961A ES 470961 A1 ES470961 A1 ES 470961A1
Authority
ES
Spain
Prior art keywords
compounds
atoms
aliphatic
free
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES470961A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES470961A1 publication Critical patent/ES470961A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C07K5/06069—Ser-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

1. Compounds of the formula see diagramm : EP0000330,P30,F1 wherein R1 and R2 each represent a saturated or unsaturated aliphatic or mixed aliphatic-cycloaliphatic hydrocarbon radical which has 11-21 C atoms and which is also optionally substituted by oxygen functions, R3 represents hydrogen or the radical R1 -CO-O-CH2 -, where R1 has the same meaning, and X represents a natural aliphatic amino acid linked by a peptide bond and having a free, esterified or amidated carboxyl group, or an amino acid sequence of 2-10 natural aliphatic amino acids, the terminal carboxyl group of which is free or in the ester or amide form, with the asymmetric centres denoted by * and ** possessing the absolute R- and S- or R-configurations, respectively and, possibly, mixtures of the R- and S-compounds epimeric on the C** atoms, and salts and complexes of all these compounds.
ES470961A 1977-06-20 1978-06-20 Lipopeptides, process for their preparation and pharmaceutical compositions containing them. Expired ES470961A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU77584 1977-06-20

Publications (1)

Publication Number Publication Date
ES470961A1 true ES470961A1 (en) 1980-03-01

Family

ID=19728618

Family Applications (3)

Application Number Title Priority Date Filing Date
ES470961A Expired ES470961A1 (en) 1977-06-20 1978-06-20 Lipopeptides, process for their preparation and pharmaceutical compositions containing them.
ES478717A Expired ES478717A1 (en) 1977-06-20 1979-03-16 Lipopeptides, process for their preparation and pharmaceutical compositions containing them.
ES478718A Expired ES478718A1 (en) 1977-06-20 1979-03-16 Lipopeptides, process for their preparation and pharmaceutical compositions containing them.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES478717A Expired ES478717A1 (en) 1977-06-20 1979-03-16 Lipopeptides, process for their preparation and pharmaceutical compositions containing them.
ES478718A Expired ES478718A1 (en) 1977-06-20 1979-03-16 Lipopeptides, process for their preparation and pharmaceutical compositions containing them.

Country Status (18)

Country Link
EP (1) EP0000330B1 (en)
JP (2) JPS549224A (en)
AT (1) AT364095B (en)
AU (1) AU525005B2 (en)
CA (1) CA1139305A (en)
DD (1) DD139257A5 (en)
DE (1) DE2860893D1 (en)
DK (1) DK275178A (en)
ES (3) ES470961A1 (en)
FI (1) FI781933A (en)
GR (1) GR71681B (en)
IE (1) IE46957B1 (en)
IL (1) IL54950A (en)
NO (1) NO148921C (en)
NZ (1) NZ187611A (en)
PL (3) PL207766A1 (en)
PT (1) PT68188A (en)
ZA (1) ZA783504B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0014815A3 (en) * 1978-12-20 1980-10-29 Ciba-Geigy Ag Peptide derivatives, process for their preparation and intermediates, and pharmaceutical compositions containing one of these compounds
DE3485094D1 (en) * 1983-01-25 1991-10-31 Ciba Geigy Ag NEW PEPTIDE DERIVATIVES.
FR2546164B1 (en) * 1983-05-16 1987-07-17 Centre Nat Rech Scient NOVEL PEPTIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS ELASTASE INHIBITORS
DE3546150A1 (en) * 1985-06-24 1987-01-22 Hoechst Ag MEMBRANE ANCHOR ACTIVE CONJUGATE, ITS PRODUCTION AND USE
US6074650A (en) * 1985-06-24 2000-06-13 Hoechst Aktiengesellschaft Membrane anchor/active compound conjugate, its preparation and its uses
US6024964A (en) * 1985-06-24 2000-02-15 Hoechst Aktiengesellschaft Membrane anchor/active compound conjugate, its preparation and its uses
DE3522638A1 (en) * 1985-06-25 1987-01-08 Diamalt Ag NEW SOMATOSTATIN DERIVATIVES
FR2611205B1 (en) * 1987-02-20 1990-03-02 Serbio DIPEPTIDES, PROCESS FOR THE PREPARATION AND USE IN THE DETERMINATION OF PROTEASES
AU626797B2 (en) * 1987-09-08 1992-08-13 Albany Medical College Immunogenic composites capable of selectively inducing antibody production, pharmaceutical compositions employing the same and method of selectively inducing antibody production
DE4119856A1 (en) * 1991-06-17 1992-12-24 Hoechst Ag N-ACYL-S- (2-HYDROXYALKYL) -CYSTEINS, THE PRODUCTION AND USE THEREOF AS INTERMEDIATE PRODUCTS FOR THE PRODUCTION OF SYNTHETIC IMMUNE ADJUVANTS AND SYNTHETIC VACCINANTS
DK0548024T3 (en) * 1991-12-19 1997-01-27 Ciba Geigy Ag Aminosulfonic acid derivatives as well as methods for their preparation
AU666789B2 (en) * 1992-12-28 1996-02-22 Takeda Chemical Industries Ltd. 2-amino-6,7-dihydroxy-4-thiaheptanoic acid derivatives, production and use thereof
EP0604945A1 (en) 1992-12-28 1994-07-06 Takeda Chemical Industries, Ltd. TAN-1511, its derivatives, production and use thereof
EP0641776A3 (en) * 1993-09-08 1997-05-02 Takeda Chemical Industries Ltd Thioglycerol derivatives.
GB9930591D0 (en) * 1999-12-23 2000-02-16 Univ London Component for vaccine
DE10048840A1 (en) * 2000-10-02 2002-04-11 Biotechnolog Forschung Gmbh Use of lipopeptides or lipoproteins to treat lung infections and tumors
FR2816060A1 (en) * 2000-10-27 2002-05-03 Pf Medicament METHOD FOR IDENTIFYING NEW MOXULES BINDING TO THE LOX RECEPTOR AND USE OF SUCH MOLECULES
ES2539490T3 (en) 2005-06-13 2015-07-01 Cleveland Biolabs, Inc. Methods to protect against apoptosis using lipopeptides
MX2008001183A (en) * 2005-07-25 2008-04-11 Therimunex Llc Peptidyl diacylglycerides.
DE102016005550A1 (en) 2016-05-09 2017-11-09 Emc Microcollections Gmbh Adjuvant for the induction of a cellular immune response
US10907764B2 (en) * 2017-11-06 2021-02-02 Crown Equipment Corporation Industrial vehicle layover system

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2706490A1 (en) 1976-02-20 1977-08-25 Ciba Geigy Ag NEW CARBON ACID ESTERS

Also Published As

Publication number Publication date
PL207766A1 (en) 1979-11-19
JPS6372671A (en) 1988-04-02
AT364095B (en) 1981-09-25
CA1139305A (en) 1983-01-11
ATA445178A (en) 1981-02-15
FI781933A (en) 1978-12-21
ZA783504B (en) 1979-06-27
ES478717A1 (en) 1979-12-16
AU525005B2 (en) 1982-10-14
DD139257A5 (en) 1979-12-19
PT68188A (en) 1978-07-01
JPS549224A (en) 1979-01-24
ES478718A1 (en) 1979-12-16
JPS6360760B2 (en) 1988-11-25
EP0000330B1 (en) 1981-08-05
DK275178A (en) 1978-12-21
JPS641466B2 (en) 1989-01-11
IE46957B1 (en) 1983-11-16
IL54950A0 (en) 1978-08-31
DE2860893D1 (en) 1981-11-05
IL54950A (en) 1983-10-31
NO148921C (en) 1984-01-11
EP0000330A1 (en) 1979-01-24
GR71681B (en) 1983-06-21
PL216740A1 (en) 1980-05-19
PL216739A1 (en) 1980-05-19
IE781227L (en) 1978-12-20
NZ187611A (en) 1981-07-13
NO148921B (en) 1983-10-03
NO782138L (en) 1978-12-21
AU3723078A (en) 1980-01-03

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990503