GB933715A - Substituted phenylalanines and manufacture thereof - Google Patents

Substituted phenylalanines and manufacture thereof

Info

Publication number
GB933715A
GB933715A GB3585159A GB3585159A GB933715A GB 933715 A GB933715 A GB 933715A GB 3585159 A GB3585159 A GB 3585159A GB 3585159 A GB3585159 A GB 3585159A GB 933715 A GB933715 A GB 933715A
Authority
GB
United Kingdom
Prior art keywords
acid
hydrogen
alkali metal
metal ion
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3585159A
Inventor
Franz Bergel
John Albert Stock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Development Corp UK
Original Assignee
National Research Development Corp UK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Development Corp UK filed Critical National Research Development Corp UK
Priority to GB3585159A priority Critical patent/GB933715A/en
Priority to CH1184360A priority patent/CH396933A/en
Publication of GB933715A publication Critical patent/GB933715A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of the general formula <FORM:0933715/IV(a)/1> (wherein R represents hydrogen, an alkali metal ion or a C1-4 alkyl group, X represents a formyl or acetyl group, and Y is a radical found in attachment to the a -carbon atom of a known naturally occurring a -amino acid containing only one amino group and carbon, hydrogen and oxygen as the only other elements), and the preparation thereof by reacting a compound of the formula <FORM:0933715/IV(a)/2> with a mixed anhydride derived from an acid <FORM:0933715/IV(a)/3> and a C1-4 alkyl ester of chloroformic acid, or with an azide <FORM:0933715/IV(a)/4> Partial racemization occurs with the first method, giving a mixture of diastereoisomers (also comprised by the invention), but not with the second method. When R in the final product is to be hydrogen it should be an alkali metal ion in the starting material, the acid being liberated from the resulting salt. Pharmaceutical preparations comprise the foregoing compounds and a pharmaceutically acceptable carrier. Specification 750,155 is referred to.
GB3585159A 1959-10-22 1959-10-22 Substituted phenylalanines and manufacture thereof Expired GB933715A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB3585159A GB933715A (en) 1959-10-22 1959-10-22 Substituted phenylalanines and manufacture thereof
CH1184360A CH396933A (en) 1959-10-22 1960-10-22 Process for the preparation of therapeutically active derivatives of p-di- (2-chloroetyl) -aminophenylalanine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3585159A GB933715A (en) 1959-10-22 1959-10-22 Substituted phenylalanines and manufacture thereof

Publications (1)

Publication Number Publication Date
GB933715A true GB933715A (en) 1963-08-14

Family

ID=10382222

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3585159A Expired GB933715A (en) 1959-10-22 1959-10-22 Substituted phenylalanines and manufacture thereof

Country Status (2)

Country Link
CH (1) CH396933A (en)
GB (1) GB933715A (en)

Also Published As

Publication number Publication date
CH396933A (en) 1965-08-15

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