GB1470154A - Dialkylaminoalkyl esters of penicillin and process for the preparation thereof - Google Patents

Dialkylaminoalkyl esters of penicillin and process for the preparation thereof

Info

Publication number
GB1470154A
GB1470154A GB2833075A GB2833075A GB1470154A GB 1470154 A GB1470154 A GB 1470154A GB 2833075 A GB2833075 A GB 2833075A GB 2833075 A GB2833075 A GB 2833075A GB 1470154 A GB1470154 A GB 1470154A
Authority
GB
United Kingdom
Prior art keywords
penicillin
crystalline
dialkylaminoalkyl esters
alkyl
july
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2833075A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Andreu SA
Original Assignee
Dr Andreu SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Andreu SA filed Critical Dr Andreu SA
Publication of GB1470154A publication Critical patent/GB1470154A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Abstract

1470154 Crystalline dialkylaminoalkyl esters of penicillin DR ANDREU SA 4 July 1975 [12 July 1974] 28330/75 Heading C2C Novel crystalline dialkylaminoalkyl esters of a penicillin of the formula wherein R may be H, C 1-4 alkyl, OH, OCH 3 , or OC 2 H 5 ; R<SP>1</SP> is an alkyl group ; n is 0 or 1; and r is from 1 to 10, may be obtained by reacting an alkali salt of penicillin in an anhydrous medium with an alkyl ester of chloroformic acid, decomposing the mixed anhydride formed by treating with a N,N-disubstituted amino alcohol, and crystallizing the product. Particular examples are crystalline benzyl penicillin diisopropylamino ethyl ester and crystalline methicillin diethylamino ethyl ester. Pharmaceutical compositions useful for the treatment of mastitis comprise an above novel compound together with a pharmaceutically acceptable diluent or medium.
GB2833075A 1974-07-12 1975-07-04 Dialkylaminoalkyl esters of penicillin and process for the preparation thereof Expired GB1470154A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES428213A ES428213A1 (en) 1974-07-12 1974-07-12 Dialkylaminoalkyl esters of penicillin and process for the preparation thereof

Publications (1)

Publication Number Publication Date
GB1470154A true GB1470154A (en) 1977-04-14

Family

ID=8467134

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2833075A Expired GB1470154A (en) 1974-07-12 1975-07-04 Dialkylaminoalkyl esters of penicillin and process for the preparation thereof

Country Status (7)

Country Link
AR (1) AR214390A1 (en)
CA (1) CA1055928A (en)
CH (1) CH595386A5 (en)
DE (1) DE2531144C3 (en)
ES (1) ES428213A1 (en)
FR (1) FR2277582A1 (en)
GB (1) GB1470154A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4215120A (en) * 1977-07-14 1980-07-29 Beecham Group Limited Penicillin esters and their preparation
JP2010512380A (en) * 2006-12-10 2010-04-22 チョンシー ユー Transdermal delivery system for β-lactam antibiotics
US9969751B2 (en) 2009-06-10 2018-05-15 Techfields Pharma Co., Ltd. High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds
US11813256B2 (en) 2012-05-16 2023-11-14 Techfields Pharma Co., Ltd. High penetration prodrug compositions and pharmaceutical compositon thereof for treatment of pulmonary conditions

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1569421A (en) * 1976-06-11 1980-06-18 Beecham Group Ltd Penicillin compositions
US4150157A (en) * 1976-06-11 1979-04-17 Beecham Group Limited Penicillin compositions

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4215120A (en) * 1977-07-14 1980-07-29 Beecham Group Limited Penicillin esters and their preparation
JP2010512380A (en) * 2006-12-10 2010-04-22 チョンシー ユー Transdermal delivery system for β-lactam antibiotics
US10233197B2 (en) 2006-12-10 2019-03-19 Techfields Pharma Co., Ltd. High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds
US9969751B2 (en) 2009-06-10 2018-05-15 Techfields Pharma Co., Ltd. High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds
US11485744B2 (en) 2009-06-10 2022-11-01 Techfields Pharma Co., Ltd. High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds
US11813256B2 (en) 2012-05-16 2023-11-14 Techfields Pharma Co., Ltd. High penetration prodrug compositions and pharmaceutical compositon thereof for treatment of pulmonary conditions
US11857545B2 (en) 2012-05-16 2024-01-02 Techfields Pharma Co., Ltd. High penetration prodrug compositions and pharmaceutical composition thereof for treatment of pulmonary conditions

Also Published As

Publication number Publication date
CH595386A5 (en) 1978-02-15
FR2277582A1 (en) 1976-02-06
FR2277582B1 (en) 1978-12-01
CA1055928A (en) 1979-06-05
DE2531144A1 (en) 1976-01-29
ES428213A1 (en) 1976-07-16
DE2531144B2 (en) 1978-02-23
DE2531144C3 (en) 1978-09-28
AR214390A1 (en) 1979-06-15

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee