GB2008096A - (2-Oxo-pyrrolidine-1)- and (2-oxo- piperidine-1) carboxylic acid hydrazides, process for the manufacture thereof, and pharmaceutical preparations containing them - Google Patents

(2-Oxo-pyrrolidine-1)- and (2-oxo- piperidine-1) carboxylic acid hydrazides, process for the manufacture thereof, and pharmaceutical preparations containing them

Info

Publication number
GB2008096A
GB2008096A GB7840009A GB7840009A GB2008096A GB 2008096 A GB2008096 A GB 2008096A GB 7840009 A GB7840009 A GB 7840009A GB 7840009 A GB7840009 A GB 7840009A GB 2008096 A GB2008096 A GB 2008096A
Authority
GB
United Kingdom
Prior art keywords
oxo
pyrrolidine
piperidine
manufacture
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7840009A
Other versions
GB2008096B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ICS CONSULTING SERVICE CO AG
Original Assignee
ICS CONSULTING SERVICE CO AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ICS CONSULTING SERVICE CO AG filed Critical ICS CONSULTING SERVICE CO AG
Publication of GB2008096A publication Critical patent/GB2008096A/en
Application granted granted Critical
Publication of GB2008096B publication Critical patent/GB2008096B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

(2-Oxo-pyrrolidine-1)- and (2-oxo- piperidine-1) carboxylic acids having the general formula: <IMAGE> in which R1 is H or 1 or more C1-4 alkyl and R2 is H or C1-4 alkyl, n is 0-4 and R3 is H or a radical IIa or IIb <IMAGE> providing the compound Ia is other than (2-oxo-pyrrolidino) acetic acid hydrazide, act as psychopharmacological drugs against retrograde and anterograde amnesia and ischemias, and have a nootropic action. The compounds are prepared by reacting the corresponding methyl ester with R3NH.NH2.
GB7840009A 1977-10-12 1978-10-10 (2-oxo-pyrrolidine-1)-and(2-oxo-piperidine-1)carboxylic acid derivatives process for the manufacture therof and pharaceutical prparations containing them Expired GB2008096B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772745907 DE2745907A1 (en) 1977-10-12 1977-10-12 (2-OXO-PYRROLIDIN-1) - AND (2-OXO-PIPERIDIN-1) -CARBONIC ACID DERIVATIVES, THE PROCESS FOR THEIR PRODUCTION, THEIR FURTHER PROCESSING AND THE PHARMACEUTICAL PREPARATIONS CONTAINING THEM

Publications (2)

Publication Number Publication Date
GB2008096A true GB2008096A (en) 1979-05-31
GB2008096B GB2008096B (en) 1982-07-28

Family

ID=6021282

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7840009A Expired GB2008096B (en) 1977-10-12 1978-10-10 (2-oxo-pyrrolidine-1)-and(2-oxo-piperidine-1)carboxylic acid derivatives process for the manufacture therof and pharaceutical prparations containing them

Country Status (6)

Country Link
JP (1) JPS5473769A (en)
BE (1) BE871207A (en)
DE (1) DE2745907A1 (en)
FR (1) FR2405944A1 (en)
GB (1) GB2008096B (en)
IT (1) IT1196396B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3006806A1 (en) * 1980-02-23 1981-09-10 Rütgerswerke AG, 6000 Frankfurt METHOD FOR PRODUCING SUBSTITUTED ACETIC ACID HYDRAZIDES
DE3006807A1 (en) * 1980-02-23 1981-09-10 Rütgerswerke AG, 6000 Frankfurt METHOD FOR PRODUCING SUBSTITUTED ACETIC ACID HYDRAZIDS
DE3031118A1 (en) * 1980-08-18 1982-04-01 Meditest Institut für medizinisch-pharmazeutische Untersuchungen GmbH & Co KG, 7958 Laupheim N, N'-BIS (5-OXO-1-METHYL-PYRROLIDIN-2-YL-ACETIC ACID) -HYDRAZIDE, METHOD FOR THE PRODUCTION THEREOF AND THE USE THEREOF AS A MEDICINAL PRODUCT
EP0417143A1 (en) * 1988-06-03 1991-03-20 The Upjohn Company Cyclic lactams for cholesterol and atherosclerosis control

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2440633C3 (en) * 1974-08-24 1980-10-30 Chemisches Laboratorium Fritzwalter Lange Gmbh & Co Kg, 8035 Gauting 1,2-bis- (2-oxo-pyrrolidine-1) acetic acid hydrazide, process for its preparation and medicinal products containing this compound

Also Published As

Publication number Publication date
FR2405944A1 (en) 1979-05-11
IT7828559A0 (en) 1978-10-09
JPS5473769A (en) 1979-06-13
GB2008096B (en) 1982-07-28
IT1196396B (en) 1988-11-16
BE871207A (en) 1979-04-12
FR2405944B1 (en) 1982-11-05
DE2745907A1 (en) 1979-04-26

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee