ES453304A1 - Amino acid derivatives - Google Patents
Amino acid derivativesInfo
- Publication number
- ES453304A1 ES453304A1 ES453304A ES453304A ES453304A1 ES 453304 A1 ES453304 A1 ES 453304A1 ES 453304 A ES453304 A ES 453304A ES 453304 A ES453304 A ES 453304A ES 453304 A1 ES453304 A1 ES 453304A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- compounds
- general formula
- formula
- see formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003862 amino acid derivatives Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 9
- -1 p-toluenesulfonyl group Chemical group 0.000 abstract 6
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 2
- 125000003158 alcohol group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- 125000002030 1,2-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([*:2])C([H])=C1[H] 0.000 abstract 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 102000002704 Leucyl aminopeptidase Human genes 0.000 abstract 1
- 108010004098 Leucyl aminopeptidase Proteins 0.000 abstract 1
- 239000012042 active reagent Substances 0.000 abstract 1
- 125000005194 alkoxycarbonyloxy group Chemical group 0.000 abstract 1
- 239000000908 ammonium hydroxide Substances 0.000 abstract 1
- 150000001540 azides Chemical class 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000007071 enzymatic hydrolysis Effects 0.000 abstract 1
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 238000007327 hydrogenolysis reaction Methods 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- ODZPKZBBUMBTMG-UHFFFAOYSA-N sodium amide Chemical compound [NH2-].[Na+] ODZPKZBBUMBTMG-UHFFFAOYSA-N 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Birds (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Nutrition Science (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
A procedure for the preparation of new amino acid derivatives of the general formula (I) ** (See formula) ** where R is a hydrogen atom or an alcohol group with 1 to 4 carbon atoms, n is an integer from 1 to 3, and m is 2 or 3, as well as the optically active salts and isomers of these compounds, characterized in that compounds of the general formula (II) are reacted ** (See formula) ** wherein R7 signifies an aralkoxy, formyl, trifluoroacetyl or p-toluenesulfonyl group, a benzyloxycarbonyl group, a -CO- group or a group of the formula (see formula) (in which R15 means an alcohol group with 1 to 4 carbon atoms, a cycloalcohyl group, an optionally substituted aralcohyl group or an optionally substituted aryl group), R8 means a hydrogen atom or a -CO- group, provided that in case R7 = R8 = -CO- group, R7 and R8 are closed on an orthophenylene group to form the ring, A4 means an aralkoxy group, preferably a benzyloxy group, a substituted aralkoxy group, preferably a p-methoxybenzyl xi group, or a p-nitrobenzyloxy group, and A7 means a hydroxyl, azide, succinimidoxy, p-nitrophenyloxy or pentachlorophenyloxy group or an alkoxycarbonyloxy group with 2 to 4 carbon atoms, with compounds of the general formula (III) ** (See formula) ** the compounds obtained from the general formula are oxidized ** (See formula) ** and is separated from the compounds obtained from the general formula (V) ** (See formula) ** the protecting group of the α-carboxyl group and are cleaved from the compounds obtained of the general formula (VI) ** (See formula) ** the protecting groups of the nitrogen atom by acidolysis, hydrogenolysis or with a dilute solution of ammonium hydroxide, sodium, sodium amide or hydrazine or by means of enzymatic hydrolysis, preferably with leucine aminopeptidase, and the obtained compounds are converted into their salts or liberated of their salts and/or the compounds are prepared in the form of their optically active isomers by using optically active reagents in any reaction step or by subjecting the compounds to racemate separation. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU74FE00000928A HU171576B (en) | 1974-04-29 | 1974-04-29 | Process for the isolation of gamma-l-glutamyl-taurine |
HU74CI1558A HU174114B (en) | 1975-03-26 | 1975-03-26 | Process for producing new aminoacid derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES453304A1 true ES453304A1 (en) | 1977-11-16 |
Family
ID=26318406
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES436986A Expired ES436986A1 (en) | 1974-04-29 | 1975-04-25 | Amino acid derivatives |
ES453305A Expired ES453305A1 (en) | 1974-04-29 | 1976-11-13 | Amino acid derivatives |
ES453304A Expired ES453304A1 (en) | 1974-04-29 | 1976-11-13 | Amino acid derivatives |
ES453306A Expired ES453306A1 (en) | 1974-04-29 | 1976-11-13 | Amino acid derivatives |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES436986A Expired ES436986A1 (en) | 1974-04-29 | 1975-04-25 | Amino acid derivatives |
ES453305A Expired ES453305A1 (en) | 1974-04-29 | 1976-11-13 | Amino acid derivatives |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES453306A Expired ES453306A1 (en) | 1974-04-29 | 1976-11-13 | Amino acid derivatives |
Country Status (23)
Country | Link |
---|---|
JP (1) | JPS6012347B2 (en) |
AR (3) | AR218221A1 (en) |
AT (6) | AT361902B (en) |
AU (1) | AU499173B2 (en) |
BE (1) | BE828546A (en) |
BG (4) | BG26517A4 (en) |
CA (1) | CA1051802A (en) |
CH (4) | CH617183A5 (en) |
CS (4) | CS209855B2 (en) |
DD (2) | DD122377A5 (en) |
DE (2) | DE2518160A1 (en) |
DK (10) | DK155433C (en) |
EG (1) | EG11847A (en) |
ES (4) | ES436986A1 (en) |
FI (1) | FI65990C (en) |
FR (1) | FR2279388A1 (en) |
GB (1) | GB1504541A (en) |
IL (1) | IL47149A (en) |
NL (1) | NL183186C (en) |
NO (2) | NO146430C (en) |
PL (2) | PL111745B1 (en) |
SE (2) | SE430164B (en) |
SU (1) | SU747419A3 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU178199B (en) * | 1976-05-06 | 1982-03-28 | Chinoin Gyogyszer Es Vegyeszet | New process for producing amides of omega-amino-carboxylic acids |
HU180443B (en) * | 1979-04-02 | 1983-03-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing a pharmaceutical preparation with synergetic action against radiation |
HU185632B (en) * | 1981-03-27 | 1985-03-28 | Chinoin Gyogyszer Es Vegyeszet | New process for preparing gamma-glutamyl-taurine |
CH665645A5 (en) * | 1981-07-09 | 1988-05-31 | Michel Flork | DIPEPTIDE DERIVATIVES AND THEIR PREPARATION PROCESS. |
HU208072B (en) * | 1990-02-28 | 1993-08-30 | Chinoin Gyogyszer Es Vegyeszet | Process for producing pharmaceutical composition suitable for preventing and curing autoimmune diseases and skin affections caused by heat and light radiacion |
JPH0680964A (en) * | 1991-12-27 | 1994-03-22 | Sogo Yatsukou Kk | Active-oxygen scavenger |
JPH11180846A (en) * | 1997-12-15 | 1999-07-06 | Sogo Pharmaceut Co Ltd | Cosmetic |
DE10133197A1 (en) * | 2001-07-07 | 2003-01-23 | Beiersdorf Ag | Use of topical compositions containing beta-amino acids, guanidinoethanesulfonate, homotaurine and their precursors and derivatives e.g. to improve skin condition and to treat or prevent skin disorders |
DK2089417T3 (en) | 2006-10-12 | 2015-03-23 | Bhi Ltd Partnership | Methods, Compounds, Compositions and Vehicles for Delivery of 3-Amion-1-Propanesulfonic Acid |
US9662304B1 (en) * | 2013-06-13 | 2017-05-30 | Thermolife International, Llc | Substituted glutaurine compounds and substituted glutaurine derivatives |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU169462B (en) * | 1971-08-04 | 1976-11-28 |
-
1975
- 1975-04-23 IL IL47149A patent/IL47149A/en unknown
- 1975-04-24 AT AT314075A patent/AT361902B/en not_active IP Right Cessation
- 1975-04-24 DE DE19752518160 patent/DE2518160A1/en active Granted
- 1975-04-24 DE DE2559989A patent/DE2559989C3/en not_active Expired
- 1975-04-25 SE SE7504828A patent/SE430164B/en not_active IP Right Cessation
- 1975-04-25 FI FI751256A patent/FI65990C/en not_active IP Right Cessation
- 1975-04-25 ES ES436986A patent/ES436986A1/en not_active Expired
- 1975-04-28 DD DD185727A patent/DD122377A5/xx unknown
- 1975-04-28 EG EG262/75A patent/EG11847A/en active
- 1975-04-28 CA CA225,659A patent/CA1051802A/en not_active Expired
- 1975-04-28 DD DD193288A patent/DD125070A5/xx unknown
- 1975-04-28 CH CH539075A patent/CH617183A5/de not_active IP Right Cessation
- 1975-04-28 GB GB17608/75A patent/GB1504541A/en not_active Expired
- 1975-04-28 SU SU752128794A patent/SU747419A3/en active
- 1975-04-28 DK DK182875A patent/DK155433C/en not_active IP Right Cessation
- 1975-04-28 FR FR7513230A patent/FR2279388A1/en active Granted
- 1975-04-28 AU AU80564/75A patent/AU499173B2/en not_active Expired
- 1975-04-28 NO NO751504A patent/NO146430C/en unknown
- 1975-04-29 BE BE155914A patent/BE828546A/en not_active IP Right Cessation
- 1975-04-29 BG BG7530769A patent/BG26517A4/xx unknown
- 1975-04-29 BG BG7530768A patent/BG26369A4/xx unknown
- 1975-04-29 BG BG7529816A patent/BG26368A3/xx unknown
- 1975-04-29 BG BG7530770A patent/BG26370A4/xx unknown
- 1975-04-29 PL PL1975196801A patent/PL111745B1/en unknown
- 1975-04-29 NL NLAANVRAGE7505075,A patent/NL183186C/en not_active IP Right Cessation
- 1975-04-29 CS CS752987A patent/CS209855B2/en unknown
- 1975-04-29 PL PL1975196798A patent/PL111746B1/en unknown
- 1975-04-30 JP JP50051612A patent/JPS6012347B2/en not_active Expired
-
1976
- 1976-04-02 AR AR262768A patent/AR218221A1/en active
- 1976-04-02 AR AR262769A patent/AR217236A1/en active
- 1976-04-02 AR AR262770A patent/AR218222A1/en active
- 1976-11-13 ES ES453305A patent/ES453305A1/en not_active Expired
- 1976-11-13 ES ES453304A patent/ES453304A1/en not_active Expired
- 1976-11-13 ES ES453306A patent/ES453306A1/en not_active Expired
-
1977
- 1977-08-30 AT AT624977A patent/AT351007B/en not_active IP Right Cessation
- 1977-08-30 AT AT624877A patent/AT359085B/en not_active IP Right Cessation
- 1977-08-30 AT AT624777A patent/AT359084B/en not_active Expired
- 1977-10-06 DK DK442577A patent/DK442577A/en not_active Application Discontinuation
- 1977-10-06 DK DK442377A patent/DK155520C/en not_active IP Right Cessation
- 1977-10-06 DK DK442877A patent/DK158676C/en active
- 1977-10-06 DK DK442477A patent/DK155732C/en not_active IP Right Cessation
- 1977-10-06 DK DK442777A patent/DK442777A/en not_active Application Discontinuation
- 1977-10-06 DK DK442677A patent/DK159654C/en not_active IP Right Cessation
- 1977-10-06 DK DK443077A patent/DK159267C/en not_active IP Right Cessation
- 1977-10-06 DK DK442977A patent/DK442977A/en unknown
-
1978
- 1978-09-22 CS CS786128A patent/CS209856B2/en unknown
- 1978-09-22 CS CS786130A patent/CS209858B2/en unknown
- 1978-09-22 CS CS786129A patent/CS209857B2/en unknown
- 1978-12-14 SE SE7812884A patent/SE441356B/en not_active IP Right Cessation
-
1979
- 1979-04-30 AT AT0323079A patent/AT374484B/en not_active IP Right Cessation
- 1979-04-30 AT AT0323179A patent/AT370724B/en not_active IP Right Cessation
- 1979-10-19 CH CH943279A patent/CH621334A5/de not_active IP Right Cessation
- 1979-10-19 CH CH943379A patent/CH624098A5/de not_active IP Right Cessation
- 1979-10-19 CH CH943179A patent/CH621333A5/de not_active IP Right Cessation
-
1981
- 1981-03-10 NO NO810816A patent/NO149036C/en unknown
-
1983
- 1983-05-31 DK DK245783A patent/DK155672C/en not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL49552A (en) | Adhesive compositions | |
GB1445503A (en) | Acylamino acid amides | |
ES453304A1 (en) | Amino acid derivatives | |
ES394915A1 (en) | 1-cyanophenoxy-2-hydroxy-3-(cycloalkyl-amino)-propanes | |
ES461987A3 (en) | Gona-4,9(10)-dienes and process of producing the same | |
GB966222A (en) | Derivatives of cephalosporin c | |
ES435498A1 (en) | Procedure for the preparation of 1- (3,5-dihydroxypenyl) -1-hydroxy-2- (1-methyl-2- (4-hydroxypenyl) -etil) -aminoethane. (Machine-translation by Google Translate, not legally binding) | |
ES459186A1 (en) | Polyprenyl carboxylic acid compound | |
ES435955A1 (en) | A procedure for obtaining a pirid derivative (3,4-d) pyridezine. (Machine-translation by Google Translate, not legally binding) | |
ES386846A1 (en) | Hydroxamic acid derivatives of alphaaminooxy carboxylic acids | |
ES442022A1 (en) | Phenylpropanolamines | |
ES438736A1 (en) | Procedure to prepare esters of dihydro-16, 17 apovincaminic acid. (Machine-translation by Google Translate, not legally binding) | |
GB1466411A (en) | Sulphur-containing hydroxy aliphatic compounds | |
GB1565413A (en) | Sulphur-containing n-(o-nitro-benzyl)-amino acids adn esters | |
ES434955A1 (en) | Derivatives of 5-hydroxy-2,3-dihydro-1h-dibenzo(2,3:6,7)thiepino and oxepino-(4,5-c)pyrrole methods for their preparation and compositions containing them | |
ES386847A1 (en) | Amino-oxy carboxylic acid amides | |
ES8200092A1 (en) | Esters of N-(4'-hydroxyphenyl)acetamide with 5-benzoyl-1-methylpyrrole-2-acetic acids. | |
GB1047257A (en) | ||
ES386042A1 (en) | A procedure for the preparation of 3-hydroxy-3-methyl-7-aminocefam-carboxylic compounds. (Machine-translation by Google Translate, not legally binding) | |
ES396174A1 (en) | Phenylethanolamine derivatives | |
ES413743A1 (en) | A procedure for the preparation of l-alpha-hydrazino-beta-phenylpropionic acid compounds. (Machine-translation by Google Translate, not legally binding) | |
GB1266718A (en) | ||
ES423226A1 (en) | Procedure for the preparation of new 1,4-benzodiazepinas. (Machine-translation by Google Translate, not legally binding) | |
ES423560A1 (en) | Peroxydicarbonates | |
ES465567A1 (en) | 2-amino-cyclopent-1-ene-1-thiocarboxylic acid-disulphides and a process for the preparation thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19981103 |