ES386847A1 - Amino-oxy carboxylic acid amides - Google Patents

Amino-oxy carboxylic acid amides

Info

Publication number
ES386847A1
ES386847A1 ES386847A ES386847A ES386847A1 ES 386847 A1 ES386847 A1 ES 386847A1 ES 386847 A ES386847 A ES 386847A ES 386847 A ES386847 A ES 386847A ES 386847 A1 ES386847 A1 ES 386847A1
Authority
ES
Spain
Prior art keywords
group
general formula
amino
compound
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES386847A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of ES386847A1 publication Critical patent/ES386847A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Procedure for the preparation of derivatives of alpha-aminooxycarboxylic acids of the general formula I **(See formula)** where X is hydrogen or an acyl radical, R is hydrogen or an alcohol, aralcohyl or aryl group; and Z signifies a substituted or unsubstituted alcohol or cycloalcoyl group, containing 1 to 15 carbon atoms, a substituted or unsubstituted aralkoxy or aryl group or a heterocyclic group, and their acid addition salts formed with therapeutically usable acids, and of the optically active isomers of the compounds containing an asymmetric carbon atom, characterized in that derivatives of alpha-amino-carboxylic acids of the general formula II are reacted **(See formula)** where A represents an acyl radical or, when X represents a hydrogen atom in the reaction product to be prepared, a suitable protecting group for the transient protection of the amino group, for example a benzyloxycarbonyl or tert-butyloxycarbonyl group, B means a group hydroxyl or a group suitable for the activation of the carboxyl group, advantageously a pentachlorophenoxy group, a halogen atom or an N3 group, and R has the above meaning, with amines of the general formula III H2N - Z (III) in which Z has the above meaning, and eventually, from the reaction product obtained from the general formula IV **(See formula)** in which A, R and Z have the above meanings, the protecting group A introduced for the transient protection of the amino group is separated in a manner known per se, and if desired the compound of the general formula I obtained is transformed into a salt by adding therapeutically usable acid and/or if desired, the compound obtained is N-acylated and/or the compound of the general formula I obtained is split in a racemic manner, in a manner known per se, into the optically active isomers. (Machine-translation by Google Translate, not legally binding)
ES386847A 1969-12-29 1970-12-26 Amino-oxy carboxylic acid amides Expired ES386847A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HURI385A HU162469B (en) 1969-12-29 1969-12-29

Publications (1)

Publication Number Publication Date
ES386847A1 true ES386847A1 (en) 1973-04-01

Family

ID=11000834

Family Applications (1)

Application Number Title Priority Date Filing Date
ES386847A Expired ES386847A1 (en) 1969-12-29 1970-12-26 Amino-oxy carboxylic acid amides

Country Status (16)

Country Link
JP (1) JPS4928740B1 (en)
AT (1) AT305242B (en)
BE (1) BE760793A (en)
CA (1) CA952113A (en)
CH (1) CH561177A5 (en)
DE (1) DE2064061C3 (en)
ES (1) ES386847A1 (en)
FI (1) FI53815C (en)
FR (1) FR2081405B1 (en)
GB (1) GB1329590A (en)
HU (1) HU162469B (en)
IL (1) IL35932A (en)
NL (1) NL7018971A (en)
NO (1) NO132393C (en)
SE (1) SE370230B (en)
YU (1) YU34514B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52134132A (en) * 1976-05-06 1977-11-10 Hitachi Ltd Controlling system for automatic burner
JPS59134740U (en) * 1983-02-23 1984-09-08 三国工業株式会社 Combustion control safety circuit
JP5583592B2 (en) 2007-11-30 2014-09-03 ニューリンク ジェネティクス コーポレイション IDO inhibitor
WO2009082020A1 (en) * 2007-12-21 2009-07-02 National Institute Of Advanced Industrial Science And Technology Reactive compound having aminooxy group

Also Published As

Publication number Publication date
SE370230B (en) 1974-10-07
BE760793A (en) 1971-05-27
FR2081405B1 (en) 1974-07-12
CH561177A5 (en) 1975-04-30
CA952113A (en) 1974-07-30
FI53815B (en) 1978-05-02
NO132393B (en) 1975-07-28
IL35932A0 (en) 1971-02-25
FR2081405A1 (en) 1971-12-03
GB1329590A (en) 1973-09-12
FI53815C (en) 1978-08-10
HU162469B (en) 1973-02-28
DE2064061A1 (en) 1971-07-15
DE2064061C3 (en) 1974-05-22
AT305242B (en) 1973-02-12
NL7018971A (en) 1971-07-01
YU34514B (en) 1979-09-10
YU318770A (en) 1979-02-28
DE2064061B2 (en) 1973-10-18
NO132393C (en) 1975-11-05
IL35932A (en) 1974-11-29
JPS4928740B1 (en) 1974-07-29

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