ES395207A1 - Acyl derivatives of substituted bis-arylalklamines - Google Patents
Acyl derivatives of substituted bis-arylalklaminesInfo
- Publication number
- ES395207A1 ES395207A1 ES395207A ES395207A ES395207A1 ES 395207 A1 ES395207 A1 ES 395207A1 ES 395207 A ES395207 A ES 395207A ES 395207 A ES395207 A ES 395207A ES 395207 A1 ES395207 A1 ES 395207A1
- Authority
- ES
- Spain
- Prior art keywords
- groups
- molecular weight
- low molecular
- group
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Procedure for the preparation of new acylarivates of substituted bis-arylalcohil-amines of the general formula ** (See formula) ** in which Ar is a phenyl or naphthyl radical, Y means an optionally substituted alcoholic group based on 1 to 4 carbon atoms; means an acyloxy, acyloxyalkoxy, acylamino or acylalkyl amino [-N (alcoholic) (acyl)] group; means hydrogen or a low molecular weight alcohol group, R5 means hydrogen, a low molecular weight alcohol group or an acyl group and R2, R3, R6 and R7, which are the same or different, mean hydrogen atoms, halogen atoms, hydroxy, low molecular weight alkoxy, acyloxy, amino, alkoxylamino, dialkyl amino, acylamino, nitro, low molecular weight alcohol, low molecular weight halogenoalcoyl, such as for example trifluoromethyl and low molecular weight alcoholyl groups and in which acyl groups they are derived from fatty acids with 2 to 10 saturated or unsaturated carbon atoms, straight or branched, possibly substituted by halogen atoms, hydroxy groups, acylated hydroxy groups, oxo groups, low molecular weight alkoxy groups or phenyl radicals, being able the phenyl radicals are also substituted by alcohol groups with 1 to 6 carbon atoms, alkoxy groups with 1 to 6 carbon atoms, hydroxy groups thus m or halogen atoms, of benzoic acids optionally substituted one or more times by halogen atoms, hydroxy groups, acylated hydroxy groups, low molecular weight alcohol groups or low molecular weight alkoxy groups or low molecular weight aliphatic semi-esters of carbonic acid or of the phenylsemi-ester of carbonic acid, as well as its salts, its optically active isomers or diastereoisomers, characterized in that, in a way known per se: a compound of the general formula is reacted ** (See formula) ** or the corresponding Mannich base of the general formula ** (See formula) ** in which the symbols Ar, as well as R1 to R4 have the meanings indicated above and R8 and R9 are low molecular weight alcohol groups or together they form a cycloalcohyl group, with a compound of the general formula II; ** (See formula) ** and optionally in the obtained compounds one or more oxo groups are reduced to hydroxy groups and/or optionally other oxy or amino groups are acylated. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT1178769A AT305987B (en) | 1969-12-18 | 1969-12-18 | Process for the preparation of new aminoketones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES395207A1 true ES395207A1 (en) | 1975-03-16 |
Family
ID=3630679
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES385918A Expired ES385918A1 (en) | 1969-12-18 | 1970-11-26 | Acyl derivatives of substituted bis-arylalklamines |
| ES395209A Expired ES395209A1 (en) | 1969-12-18 | 1971-09-18 | Acyl derivatives of substituted bis-arylalklamines |
| ES395207A Expired ES395207A1 (en) | 1969-12-18 | 1971-09-18 | Acyl derivatives of substituted bis-arylalklamines |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES385918A Expired ES385918A1 (en) | 1969-12-18 | 1970-11-26 | Acyl derivatives of substituted bis-arylalklamines |
| ES395209A Expired ES395209A1 (en) | 1969-12-18 | 1971-09-18 | Acyl derivatives of substituted bis-arylalklamines |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS5245701B1 (en) |
| AT (1) | AT305987B (en) |
| BE (1) | BE760505A (en) |
| CA (1) | CA992979A (en) |
| CH (4) | CH566963A5 (en) |
| DE (1) | DE2061864C3 (en) |
| DK (1) | DK137380B (en) |
| ES (3) | ES385918A1 (en) |
| FI (1) | FI53700C (en) |
| FR (1) | FR2081381B1 (en) |
| GB (1) | GB1332930A (en) |
| NL (1) | NL164552C (en) |
| SE (1) | SE383874B (en) |
| SU (3) | SU507224A3 (en) |
| YU (1) | YU35434B (en) |
| ZA (1) | ZA708151B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4285970A (en) | 1980-01-25 | 1981-08-25 | Shell Oil Company | N-Phenethylaminopropiophenones as lipogenesis inhibitors |
| US4279929A (en) | 1980-01-25 | 1981-07-21 | Shell Oil Company | N-Phenethylaminopropiophenones as lipogenesis inhibitors |
| US4279925A (en) | 1980-01-25 | 1981-07-21 | Shell Oil Company | N-Phenethylaminopropiophenones as lipogenesis inhibitors |
| US4305960A (en) | 1980-01-25 | 1981-12-15 | Shell Oil Company | N-Phenethylaminopropiophenones as lipogenesis inhibitors |
| US4276307A (en) | 1980-01-25 | 1981-06-30 | Shell Oil Company | N-Phenethylaminopropiophenones as lipogenesis inhibitors |
| IL156669A0 (en) | 2003-06-26 | 2004-01-04 | Neurim Pharma 1991 | 2-aminobenzoyl derivatives |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6609318A (en) * | 1966-07-04 | 1968-01-05 |
-
1969
- 1969-12-18 AT AT1178769A patent/AT305987B/en not_active IP Right Cessation
-
1970
- 1970-11-26 ES ES385918A patent/ES385918A1/en not_active Expired
- 1970-12-02 YU YU2927/70A patent/YU35434B/en unknown
- 1970-12-02 ZA ZA708151A patent/ZA708151B/en unknown
- 1970-12-08 NL NL7017884.A patent/NL164552C/en not_active IP Right Cessation
- 1970-12-10 FI FI3330/70A patent/FI53700C/en active
- 1970-12-15 CH CH1859570A patent/CH566963A5/xx not_active IP Right Cessation
- 1970-12-15 CH CH1342973A patent/CH566290A5/xx not_active IP Right Cessation
- 1970-12-15 CH CH1342773A patent/CH566288A5/xx not_active IP Right Cessation
- 1970-12-15 CH CH1342873A patent/CH566289A5/xx not_active IP Right Cessation
- 1970-12-16 DE DE2061864A patent/DE2061864C3/en not_active Expired
- 1970-12-16 SU SU1740985A patent/SU507224A3/en active
- 1970-12-16 SU SU1499482A patent/SU470108A3/en active
- 1970-12-16 SE SE7017064A patent/SE383874B/en unknown
- 1970-12-16 SU SU1740556A patent/SU493956A3/en active
- 1970-12-17 DK DK642170AA patent/DK137380B/en unknown
- 1970-12-17 BE BE760505A patent/BE760505A/en unknown
- 1970-12-18 CA CA101,047A patent/CA992979A/en not_active Expired
- 1970-12-18 FR FR7045775A patent/FR2081381B1/fr not_active Expired
- 1970-12-18 JP JP45114020A patent/JPS5245701B1/ja active Pending
- 1970-12-18 GB GB6019370A patent/GB1332930A/en not_active Expired
-
1971
- 1971-09-18 ES ES395209A patent/ES395209A1/en not_active Expired
- 1971-09-18 ES ES395207A patent/ES395207A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH566289A5 (en) | 1975-09-15 |
| YU292770A (en) | 1980-06-30 |
| BE760505A (en) | 1971-05-27 |
| FR2081381A1 (en) | 1971-12-03 |
| DE2061864A1 (en) | 1971-10-14 |
| SU493956A3 (en) | 1975-11-28 |
| SU470108A3 (en) | 1975-05-05 |
| CA992979A (en) | 1976-07-13 |
| DK137380B (en) | 1978-02-27 |
| YU35434B (en) | 1981-02-28 |
| CH566290A5 (en) | 1975-09-15 |
| DE2061864B2 (en) | 1979-06-28 |
| FI53700C (en) | 1978-07-10 |
| GB1332930A (en) | 1973-10-10 |
| SE383874B (en) | 1976-04-05 |
| AT305987B (en) | 1973-03-26 |
| FI53700B (en) | 1978-03-31 |
| JPS5245701B1 (en) | 1977-11-17 |
| NL164552B (en) | 1980-08-15 |
| ES385918A1 (en) | 1973-05-01 |
| DK137380C (en) | 1978-07-31 |
| FR2081381B1 (en) | 1974-03-22 |
| CH566963A5 (en) | 1975-09-30 |
| SU507224A3 (en) | 1976-03-15 |
| NL164552C (en) | 1981-01-15 |
| SU440826A3 (en) | 1974-08-25 |
| ZA708151B (en) | 1971-12-29 |
| NL7017884A (en) | 1971-06-22 |
| DE2061864C3 (en) | 1980-03-13 |
| ES395209A1 (en) | 1975-03-01 |
| CH566288A5 (en) | 1975-09-15 |
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