GB1332930A - Acyl derivatives of substituted bis-arylalklamines - Google Patents
Acyl derivatives of substituted bis-arylalklaminesInfo
- Publication number
- GB1332930A GB1332930A GB6019370A GB6019370A GB1332930A GB 1332930 A GB1332930 A GB 1332930A GB 6019370 A GB6019370 A GB 6019370A GB 6019370 A GB6019370 A GB 6019370A GB 1332930 A GB1332930 A GB 1332930A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compounds
- alkyl
- reacting
- methylphenethylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
1332930 Acyl derivatives DEUTSCHE GOLDUND SILBER-SCHEIDEANSTALT 18 Dec 1970 [18 Dec 1969] 60193/70 Heading C2C The invention comprises acyl derivatives of the formula in whieh Ar is phenyl or naphthyl; X is O or OH plus. H; Y is optionally substituted C 1-4 alkylene; R<SP>1</SP> is acyloxy, acyloxyalkoxy, aeylamino, or -N(alkyl)acyl; R<SP>4</SP> is H or C 1-6 alkyl; R<SP>5</SP> is H, C 1-6 alkyl or acyl; and R<SP>2</SP>, R<SP>3</SP>, R<SP>6</SP> and R? each are H, halogen, OH, C 1-6 alkoxy, acyloxy, amine, alkylamino, dialkylamino, acylamino, NO 2 , C 1-6 alkyl, C 1-6 haloalkyl or C 1-6 alkylthio, and acid addition salts thereof. Compounds of the above Formula I in which X is O are prepared by reacting ketones of the Formula II with amines of the Formula VII wherein W is -NHR<SP>5</SP>, in the presence of formaldehyde or formaldehyde donors, or by reacting compounds of the formula or in which R<SP>8</SP> and R<SP>9</SP> each are C 1-6 alkyl or together with the N atom to which they are attached form a saturated heterocyclic ring. The compounds of Formula I above may also be obtained by reacting compounds of the formula with compounds of Formula VII above in which Z and W are different from one another and one is halogen while the other is NHR<SP>5</SP> in the presence of bases, or by reducing compounds of the formula or by acylating amino, alkylamino, hydroxy, or hydroxyalkyl groups. dl - # - [#,p - Dihydroxy - α - methylphenethylamino] - 3 - aminopropiophenone hydrochloride is obtained by reducing d,l-#-[#,p-dihydroxy-α- methylphenethylamino]- 3 - nitropropiophenone hydrochloride, resulting from the reaction between 3-nitro-acetophenone, d,l-4-hydroxynorephedrine and paraformaldehyde. dl - # - [#,p - Dihydroxy - α - methylphenethylamino] - 3 - (#,# - dimethylacryloylamino)acrylophenone is prepared by reacting 3-(##-dimethylacryloylamino)acetophenone with sodium, ethyl formate and l-p-hydroxynorephedrine. Pharmaceutical compositions, enteral, parenteral or oral administration, contain the above novel compounds or acid addition salts thereof in admixture with further unspecified pharmaceutically active substances and pharmaceutically acceptable excipients or additives. The compounds possess antiphlogistic, analgesic, antipyretic, broncholytic and cardiocirculatory activity.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT1178769A AT305987B (en) | 1969-12-18 | 1969-12-18 | Process for the preparation of new aminoketones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1332930A true GB1332930A (en) | 1973-10-10 |
Family
ID=3630679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB6019370A Expired GB1332930A (en) | 1969-12-18 | 1970-12-18 | Acyl derivatives of substituted bis-arylalklamines |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS5245701B1 (en) |
| AT (1) | AT305987B (en) |
| BE (1) | BE760505A (en) |
| CA (1) | CA992979A (en) |
| CH (4) | CH566289A5 (en) |
| DE (1) | DE2061864C3 (en) |
| DK (1) | DK137380B (en) |
| ES (3) | ES385918A1 (en) |
| FI (1) | FI53700C (en) |
| FR (1) | FR2081381B1 (en) |
| GB (1) | GB1332930A (en) |
| NL (1) | NL164552C (en) |
| SE (1) | SE383874B (en) |
| SU (3) | SU507224A3 (en) |
| YU (1) | YU35434B (en) |
| ZA (1) | ZA708151B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4276307A (en) | 1980-01-25 | 1981-06-30 | Shell Oil Company | N-Phenethylaminopropiophenones as lipogenesis inhibitors |
| US4279925A (en) | 1980-01-25 | 1981-07-21 | Shell Oil Company | N-Phenethylaminopropiophenones as lipogenesis inhibitors |
| US4279929A (en) | 1980-01-25 | 1981-07-21 | Shell Oil Company | N-Phenethylaminopropiophenones as lipogenesis inhibitors |
| US4285970A (en) | 1980-01-25 | 1981-08-25 | Shell Oil Company | N-Phenethylaminopropiophenones as lipogenesis inhibitors |
| US4305960A (en) | 1980-01-25 | 1981-12-15 | Shell Oil Company | N-Phenethylaminopropiophenones as lipogenesis inhibitors |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL156669A0 (en) | 2003-06-26 | 2004-01-04 | Neurim Pharma 1991 | 2-aminobenzoyl derivatives |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6609318A (en) * | 1966-07-04 | 1968-01-05 |
-
1969
- 1969-12-18 AT AT1178769A patent/AT305987B/en not_active IP Right Cessation
-
1970
- 1970-11-26 ES ES385918A patent/ES385918A1/en not_active Expired
- 1970-12-02 YU YU2927/70A patent/YU35434B/en unknown
- 1970-12-02 ZA ZA708151A patent/ZA708151B/en unknown
- 1970-12-08 NL NL7017884.A patent/NL164552C/en not_active IP Right Cessation
- 1970-12-10 FI FI3330/70A patent/FI53700C/en active
- 1970-12-15 CH CH1342873A patent/CH566289A5/xx not_active IP Right Cessation
- 1970-12-15 CH CH1342973A patent/CH566290A5/xx not_active IP Right Cessation
- 1970-12-15 CH CH1859570A patent/CH566963A5/xx not_active IP Right Cessation
- 1970-12-15 CH CH1342773A patent/CH566288A5/xx not_active IP Right Cessation
- 1970-12-16 DE DE2061864A patent/DE2061864C3/en not_active Expired
- 1970-12-16 SU SU1740985A patent/SU507224A3/en active
- 1970-12-16 SE SE7017064A patent/SE383874B/en unknown
- 1970-12-16 SU SU1740556A patent/SU493956A3/en active
- 1970-12-16 SU SU1499482A patent/SU470108A3/en active
- 1970-12-17 BE BE760505A patent/BE760505A/en unknown
- 1970-12-17 DK DK642170AA patent/DK137380B/en unknown
- 1970-12-18 FR FR7045775A patent/FR2081381B1/fr not_active Expired
- 1970-12-18 CA CA101,047A patent/CA992979A/en not_active Expired
- 1970-12-18 GB GB6019370A patent/GB1332930A/en not_active Expired
- 1970-12-18 JP JP45114020A patent/JPS5245701B1/ja active Pending
-
1971
- 1971-09-18 ES ES395207A patent/ES395207A1/en not_active Expired
- 1971-09-18 ES ES395209A patent/ES395209A1/en not_active Expired
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4276307A (en) | 1980-01-25 | 1981-06-30 | Shell Oil Company | N-Phenethylaminopropiophenones as lipogenesis inhibitors |
| US4279925A (en) | 1980-01-25 | 1981-07-21 | Shell Oil Company | N-Phenethylaminopropiophenones as lipogenesis inhibitors |
| US4279929A (en) | 1980-01-25 | 1981-07-21 | Shell Oil Company | N-Phenethylaminopropiophenones as lipogenesis inhibitors |
| US4285970A (en) | 1980-01-25 | 1981-08-25 | Shell Oil Company | N-Phenethylaminopropiophenones as lipogenesis inhibitors |
| US4305960A (en) | 1980-01-25 | 1981-12-15 | Shell Oil Company | N-Phenethylaminopropiophenones as lipogenesis inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| ES395209A1 (en) | 1975-03-01 |
| FI53700B (en) | 1978-03-31 |
| YU35434B (en) | 1981-02-28 |
| CA992979A (en) | 1976-07-13 |
| YU292770A (en) | 1980-06-30 |
| FR2081381A1 (en) | 1971-12-03 |
| ES395207A1 (en) | 1975-03-16 |
| CH566288A5 (en) | 1975-09-15 |
| NL7017884A (en) | 1971-06-22 |
| ES385918A1 (en) | 1973-05-01 |
| SU507224A3 (en) | 1976-03-15 |
| CH566290A5 (en) | 1975-09-15 |
| DE2061864A1 (en) | 1971-10-14 |
| CH566963A5 (en) | 1975-09-30 |
| DE2061864B2 (en) | 1979-06-28 |
| AT305987B (en) | 1973-03-26 |
| SU440826A3 (en) | 1974-08-25 |
| NL164552C (en) | 1981-01-15 |
| CH566289A5 (en) | 1975-09-15 |
| NL164552B (en) | 1980-08-15 |
| DK137380C (en) | 1978-07-31 |
| ZA708151B (en) | 1971-12-29 |
| BE760505A (en) | 1971-05-27 |
| SE383874B (en) | 1976-04-05 |
| JPS5245701B1 (en) | 1977-11-17 |
| SU493956A3 (en) | 1975-11-28 |
| FR2081381B1 (en) | 1974-03-22 |
| DE2061864C3 (en) | 1980-03-13 |
| DK137380B (en) | 1978-02-27 |
| FI53700C (en) | 1978-07-10 |
| SU470108A3 (en) | 1975-05-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |