FR2279388A1 - NEW AMINO ACID DERIVATIVES AND METHODS FOR THEIR PREPARATION - Google Patents

NEW AMINO ACID DERIVATIVES AND METHODS FOR THEIR PREPARATION

Info

Publication number
FR2279388A1
FR2279388A1 FR7513230A FR7513230A FR2279388A1 FR 2279388 A1 FR2279388 A1 FR 2279388A1 FR 7513230 A FR7513230 A FR 7513230A FR 7513230 A FR7513230 A FR 7513230A FR 2279388 A1 FR2279388 A1 FR 2279388A1
Authority
FR
France
Prior art keywords
preparation
methods
amino acid
acid derivatives
new amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7513230A
Other languages
French (fr)
Other versions
FR2279388B1 (en
Inventor
Laszlo Feuer
Arpad Furka
Ferenc Sebestyen
Jolan Hercsel
Erzsebet Bendefy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU74FE00000928A external-priority patent/HU171576B/en
Priority claimed from HU74CI1558A external-priority patent/HU174114B/en
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of FR2279388A1 publication Critical patent/FR2279388A1/en
Application granted granted Critical
Publication of FR2279388B1 publication Critical patent/FR2279388B1/fr
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/08Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/55Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/10Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • C07F9/091Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Birds (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Nutrition Science (AREA)
  • Biophysics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FR7513230A 1974-04-29 1975-04-28 NEW AMINO ACID DERIVATIVES AND METHODS FOR THEIR PREPARATION Granted FR2279388A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU74FE00000928A HU171576B (en) 1974-04-29 1974-04-29 Process for the isolation of gamma-l-glutamyl-taurine
HU74CI1558A HU174114B (en) 1975-03-26 1975-03-26 Process for producing new aminoacid derivatives

Publications (2)

Publication Number Publication Date
FR2279388A1 true FR2279388A1 (en) 1976-02-20
FR2279388B1 FR2279388B1 (en) 1978-07-28

Family

ID=26318406

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7513230A Granted FR2279388A1 (en) 1974-04-29 1975-04-28 NEW AMINO ACID DERIVATIVES AND METHODS FOR THEIR PREPARATION

Country Status (23)

Country Link
JP (1) JPS6012347B2 (en)
AR (3) AR217236A1 (en)
AT (6) AT361902B (en)
AU (1) AU499173B2 (en)
BE (1) BE828546A (en)
BG (4) BG26369A4 (en)
CA (1) CA1051802A (en)
CH (4) CH617183A5 (en)
CS (4) CS209855B2 (en)
DD (2) DD122377A5 (en)
DE (2) DE2559989C3 (en)
DK (10) DK155433C (en)
EG (1) EG11847A (en)
ES (4) ES436986A1 (en)
FI (1) FI65990C (en)
FR (1) FR2279388A1 (en)
GB (1) GB1504541A (en)
IL (1) IL47149A (en)
NL (1) NL183186C (en)
NO (2) NO146430C (en)
PL (2) PL111745B1 (en)
SE (2) SE430164B (en)
SU (1) SU747419A3 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2452929A1 (en) * 1979-04-02 1980-10-31 Chinoin Gyogyszer Es Vegyeszet SYNERGISTIC PHARMACEUTICAL COMPOSITIONS PROTECTING AGAINST RADIATION
EP0069674A1 (en) * 1981-07-09 1983-01-12 Societe Bfb Medicines containing an N-acyl-L-aspactyl-taurine

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU178199B (en) * 1976-05-06 1982-03-28 Chinoin Gyogyszer Es Vegyeszet New process for producing amides of omega-amino-carboxylic acids
HU185632B (en) * 1981-03-27 1985-03-28 Chinoin Gyogyszer Es Vegyeszet New process for preparing gamma-glutamyl-taurine
HU208072B (en) * 1990-02-28 1993-08-30 Chinoin Gyogyszer Es Vegyeszet Process for producing pharmaceutical composition suitable for preventing and curing autoimmune diseases and skin affections caused by heat and light radiacion
JPH0680964A (en) * 1991-12-27 1994-03-22 Sogo Yatsukou Kk Active-oxygen scavenger
JPH11180846A (en) * 1997-12-15 1999-07-06 Sogo Pharmaceut Co Ltd Cosmetic
DE10133197A1 (en) * 2001-07-07 2003-01-23 Beiersdorf Ag Use of topical compositions containing beta-amino acids, guanidinoethanesulfonate, homotaurine and their precursors and derivatives e.g. to improve skin condition and to treat or prevent skin disorders
FI3851447T3 (en) 2006-10-12 2023-11-15 Bellus Health Inc Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid
US9662304B1 (en) * 2013-06-13 2017-05-30 Thermolife International, Llc Substituted glutaurine compounds and substituted glutaurine derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU169462B (en) * 1971-08-04 1976-11-28

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2452929A1 (en) * 1979-04-02 1980-10-31 Chinoin Gyogyszer Es Vegyeszet SYNERGISTIC PHARMACEUTICAL COMPOSITIONS PROTECTING AGAINST RADIATION
EP0069674A1 (en) * 1981-07-09 1983-01-12 Societe Bfb Medicines containing an N-acyl-L-aspactyl-taurine

Also Published As

Publication number Publication date
NO149036B (en) 1983-10-24
ATA624777A (en) 1980-03-15
DK442577A (en) 1977-10-06
NO146430B (en) 1982-06-21
DK245783D0 (en) 1983-05-31
DE2518160C2 (en) 1993-05-06
DK442377A (en) 1977-10-06
AT351007B (en) 1979-07-10
BG26517A4 (en) 1979-04-12
ATA624877A (en) 1980-03-15
AU499173B2 (en) 1979-04-05
SU747419A3 (en) 1980-07-23
DK155672B (en) 1989-05-01
DK442977A (en) 1977-10-06
CH624098A5 (en) 1981-07-15
CS209857B2 (en) 1981-12-31
DK155433C (en) 1989-10-16
DK159654B (en) 1990-11-12
DK155732B (en) 1989-05-08
NO751504L (en) 1975-10-30
AT361902B (en) 1981-04-10
ATA323079A (en) 1983-09-15
DD122377A5 (en) 1976-10-05
CH617183A5 (en) 1980-05-14
DK442677A (en) 1977-10-06
GB1504541A (en) 1978-03-22
ATA323179A (en) 1982-09-15
DK442877A (en) 1977-10-06
AT359084B (en) 1980-10-27
AR218222A1 (en) 1980-05-30
ES436986A1 (en) 1977-06-16
SE7812884L (en) 1978-12-14
SE7504828L (en) 1975-10-30
JPS514121A (en) 1976-01-14
DK158676C (en) 1991-01-14
DK443077A (en) 1977-10-06
SE441356B (en) 1985-09-30
AU8056475A (en) 1976-11-04
CS209858B2 (en) 1981-12-31
NL7505075A (en) 1975-10-31
AT359085B (en) 1980-10-27
DK158676B (en) 1990-07-02
DK442477A (en) 1977-10-06
NL183186C (en) 1988-08-16
AT374484B (en) 1984-04-25
PL111746B1 (en) 1980-09-30
IL47149A0 (en) 1975-06-25
CS209855B2 (en) 1981-12-31
SE430164B (en) 1983-10-24
AR217236A1 (en) 1980-03-14
NO149036C (en) 1984-02-01
FI65990B (en) 1984-04-30
ATA624977A (en) 1978-12-15
DK155732C (en) 1989-10-02
CH621333A5 (en) 1981-01-30
CS209856B2 (en) 1981-12-31
EG11847A (en) 1979-06-30
BG26370A4 (en) 1979-03-15
DK182875A (en) 1975-10-30
AT370724B (en) 1983-04-25
DK245783A (en) 1983-05-31
NO146430C (en) 1982-09-29
DK155433B (en) 1989-04-10
AR218221A1 (en) 1980-05-30
DK159267C (en) 1991-02-18
BG26369A4 (en) 1979-03-15
BE828546A (en) 1975-08-18
DK159654C (en) 1991-04-08
FI65990C (en) 1984-08-10
DK155520B (en) 1989-04-17
DK155672C (en) 1989-10-09
DE2559989B1 (en) 1981-02-05
DK442777A (en) 1977-10-06
CH621334A5 (en) 1981-01-30
ATA314075A (en) 1980-09-15
CA1051802A (en) 1979-04-03
JPS6012347B2 (en) 1985-04-01
DK155520C (en) 1989-10-16
ES453305A1 (en) 1977-11-16
PL111745B1 (en) 1980-09-30
IL47149A (en) 1979-05-31
NO810816L (en) 1975-10-30
DE2518160A1 (en) 1975-11-20
ES453306A1 (en) 1977-11-16
DE2559989C3 (en) 1981-11-19
BG26368A3 (en) 1979-03-15
ES453304A1 (en) 1977-11-16
DD125070A5 (en) 1977-03-30
DK159267B (en) 1990-09-24
FI751256A (en) 1975-10-30
FR2279388B1 (en) 1978-07-28

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