FR2298335A1 - NEW DERIVATIVES OF PHOSPHONIC AND PHOSPHINIC ACID PEPTIDES - Google Patents

NEW DERIVATIVES OF PHOSPHONIC AND PHOSPHINIC ACID PEPTIDES

Info

Publication number
FR2298335A1
FR2298335A1 FR7601973A FR7601973A FR2298335A1 FR 2298335 A1 FR2298335 A1 FR 2298335A1 FR 7601973 A FR7601973 A FR 7601973A FR 7601973 A FR7601973 A FR 7601973A FR 2298335 A1 FR2298335 A1 FR 2298335A1
Authority
FR
France
Prior art keywords
phosphonic
phosphinic acid
new derivatives
acid peptides
peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7601973A
Other languages
French (fr)
Other versions
FR2298335B1 (en
Inventor
Frank Ratcliffe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB3417/75A external-priority patent/GB1533239A/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of FR2298335A1 publication Critical patent/FR2298335A1/en
Priority to DE19772702422 priority Critical patent/DE2702422A1/en
Application granted granted Critical
Publication of FR2298335B1 publication Critical patent/FR2298335B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Polymers & Plastics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR7601973A 1975-01-27 1976-01-26 NEW DERIVATIVES OF PHOSPHONIC AND PHOSPHINIC ACID PEPTIDES Granted FR2298335A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19772702422 DE2702422A1 (en) 1976-01-26 1977-01-21 Fuel injector lance, esp. for blast furnace blower - has inclined high speed atomising ducts and radial outlets

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB3417/75A GB1533239A (en) 1975-01-27 1975-01-27 Peptide derivatives of phosphonic and phosphinic acids
GB4778775 1975-11-20

Publications (2)

Publication Number Publication Date
FR2298335A1 true FR2298335A1 (en) 1976-08-20
FR2298335B1 FR2298335B1 (en) 1980-06-20

Family

ID=26238285

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7601973A Granted FR2298335A1 (en) 1975-01-27 1976-01-26 NEW DERIVATIVES OF PHOSPHONIC AND PHOSPHINIC ACID PEPTIDES

Country Status (26)

Country Link
US (1) US4016148A (en)
JP (1) JPS598278B2 (en)
AR (1) AR218850A1 (en)
AT (1) AT359217B (en)
AU (1) AU502919B2 (en)
BR (1) BR7600449A (en)
CA (1) CA1065857A (en)
CH (2) CH624965A5 (en)
DD (1) DD123756A5 (en)
DE (1) DE2602193C2 (en)
DK (1) DK143755C (en)
DO (1) DOP1976002544A (en)
ES (1) ES444622A1 (en)
FI (1) FI61032C (en)
FR (1) FR2298335A1 (en)
GR (1) GR58609B (en)
HU (1) HU176800B (en)
IE (1) IE42466B1 (en)
IL (1) IL48835A (en)
LU (1) LU74249A1 (en)
NL (1) NL177021C (en)
NO (1) NO146429C (en)
PH (1) PH16560A (en)
PL (1) PL99096B1 (en)
PT (1) PT64743B (en)
SE (2) SE424328B (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2351125A1 (en) * 1976-05-14 1977-12-09 Hoffmann La Roche Antibacterial phosphonic acid peptide derivs. - prepd. e.g. by removing protecting groups from corresponding protected peptides
FR2351124A1 (en) * 1976-05-14 1977-12-09 Hoffmann La Roche PEPTIDIC DERIVATIVES AND PROCESS FOR THEIR PREPARATION
FR2358414A1 (en) * 1976-07-13 1978-02-10 Hoffmann La Roche Antibacterial (N)-acyl peptide phosphonic acid derivs. - with activity against Gram positive and negative organisms
FR2358415A1 (en) * 1976-07-13 1978-02-10 Hoffmann La Roche PEPTIDIC DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS
FR2359154A1 (en) * 1976-07-21 1978-02-17 Hoffmann La Roche PEPTIDIC DERIVATIVES USEFUL AS MEDICINAL PRODUCTS AND PROCESS FOR THEIR PREPARATION
EP0010067A2 (en) * 1978-10-05 1980-04-16 Ciba-Geigy Ag Process for influencing plant growth
FR2584077A1 (en) * 1985-06-28 1987-01-02 Irceba L-DI OR TRIPEPTIDES HAVING BIOLOGICAL ACTIVITY FOR USE IN HUMAN AND VETERINARY MEDICINE, PROCESS FOR OBTAINING THEM AND MEDICAMENT CONTAINING THE SAME

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179464A (en) * 1977-11-14 1979-12-18 Schultz Robert J Preparation of N-(phosphonoacetyl)-L-aspartic acid
EP0002039A1 (en) * 1977-11-19 1979-05-30 Ciba-Geigy Ag Phosphonous acid derivatives, processes for their preparation and their use in combating microorganisms
CA1108125A (en) * 1977-12-23 1981-09-01 Frank R. Atherton Olgiopeptide derivatives of phosphonic acid
US4178306A (en) * 1978-08-10 1979-12-11 Parsons Jack L Preparation of N-(phosphonoacetyl)-L-aspartic acid
US4154759A (en) * 1978-08-10 1979-05-15 Henryk Dubicki Preparation of N-(phosphonoacetyl)-L-aspartic acid
US4331591A (en) * 1978-10-05 1982-05-25 Ciba-Geigy Corporation Chemical process for the production of α-aminophosphonic acids and peptide derivatives
EP0026867A1 (en) * 1979-09-28 1981-04-15 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Peptidylphosphonic acids, their preparation and use, and pharmaceutical preparations containing them
JPS5831992A (en) * 1981-08-19 1983-02-24 Kyowa Hakko Kogyo Co Ltd Novel physiologically active substance k-4 and its preparation
JPS5885897A (en) * 1981-11-17 1983-05-23 Kyowa Hakko Kogyo Co Ltd Optical active 1-amino-2-(4-hydroxyphenyl)ethylphosphonic acid and its derivative
JPS57156498A (en) * 1981-03-20 1982-09-27 Kyowa Hakko Kogyo Co Ltd Novel physiologically active substance k-26
EP0103867B1 (en) * 1982-09-17 1986-12-17 Kyowa Hakko Kogyo Co., Ltd. Phosphorus-containing peptide derivative
US4463092A (en) * 1982-09-27 1984-07-31 Eli Lilly And Company Process for production antibiotic A53868
US4482488A (en) * 1982-09-27 1984-11-13 Eli Lilly And Company Antibiotic A53868 and process for production thereof
PT77368A (en) * 1982-09-27 1983-10-01 Lilly Co Eli Improved process for preparing immunomodulating agents or rela-ting there to
DE3669512D1 (en) 1985-06-11 1990-04-19 Ciba Geigy Ag MICROBICIDAL AGENTS.
GB8726714D0 (en) * 1987-11-14 1987-12-16 Beecham Group Plc Compounds
WO1989007940A1 (en) * 1988-03-03 1989-09-08 E.R. Squibb & Sons, Inc. 1,2-hydroxy phosphonates and derivatives thereof
AU3964489A (en) * 1988-07-08 1990-02-05 Smithkline Beckman Corporation Retroviral protease binding peptides
US5468732A (en) * 1989-02-16 1995-11-21 Pfizer Inc. Phosphorus containing renin inhibitors
WO1990009172A1 (en) * 1989-02-16 1990-08-23 Pfizer Inc. Phosphorus containing renin inhibitors
US5321153A (en) * 1992-06-15 1994-06-14 Monsanto Company Process for making chiral alpha-amino phosphonates selected novel chiral alpha-amino phosphonates
US5473092A (en) * 1992-11-20 1995-12-05 Monsanto Company Synthesis of optically-active phosphono analogs of succinates
GB0022556D0 (en) * 2000-09-14 2000-11-01 Oxoid Ltd Improvements in or relating to selective agents for biological cultures
EP1325024B1 (en) * 2000-09-18 2011-04-20 The Newcastle upon Tyne Hospitals National Health Service Trust Selective growth media

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3893992A (en) * 1970-11-19 1975-07-08 Rohm & Haas N-acylated peptides of amino aromatic sulfonic acids and their derivatives
GB1445087A (en) * 1972-11-08 1976-08-04 Ici Ltd Preparing n-phosphonomethylglycine and nitrile intermediates therefor
US3954860A (en) * 1973-08-06 1976-05-04 Monsanto Company Phosphorous compounds
US3969398A (en) * 1974-05-01 1976-07-13 Monsanto Company Process for producing N-phosphonomethyl glycine

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2351125A1 (en) * 1976-05-14 1977-12-09 Hoffmann La Roche Antibacterial phosphonic acid peptide derivs. - prepd. e.g. by removing protecting groups from corresponding protected peptides
FR2351124A1 (en) * 1976-05-14 1977-12-09 Hoffmann La Roche PEPTIDIC DERIVATIVES AND PROCESS FOR THEIR PREPARATION
FR2358414A1 (en) * 1976-07-13 1978-02-10 Hoffmann La Roche Antibacterial (N)-acyl peptide phosphonic acid derivs. - with activity against Gram positive and negative organisms
FR2358415A1 (en) * 1976-07-13 1978-02-10 Hoffmann La Roche PEPTIDIC DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS
FR2359154A1 (en) * 1976-07-21 1978-02-17 Hoffmann La Roche PEPTIDIC DERIVATIVES USEFUL AS MEDICINAL PRODUCTS AND PROCESS FOR THEIR PREPARATION
EP0010067A2 (en) * 1978-10-05 1980-04-16 Ciba-Geigy Ag Process for influencing plant growth
EP0010067A3 (en) * 1978-10-05 1980-04-30 Ciba-Geigy Ag Agent and process for influencing plant growth
FR2584077A1 (en) * 1985-06-28 1987-01-02 Irceba L-DI OR TRIPEPTIDES HAVING BIOLOGICAL ACTIVITY FOR USE IN HUMAN AND VETERINARY MEDICINE, PROCESS FOR OBTAINING THEM AND MEDICAMENT CONTAINING THE SAME
EP0209430A2 (en) * 1985-06-28 1987-01-21 INSTITUT DE RECHERCHES CHIMIQUES ET BIOLOGIQUES APPLIQUEES (I.R.C.E.B.A.) Société à responsabilité limitée dite: L-di or tripeptides possessing a biological activity for use in human and veterinary medicines, process for their obtention and medicines containing them
EP0209430A3 (en) * 1985-06-28 1988-10-05 Institut De Recherches Chimiques Et Biologiques Appliquees (I.R.C.E.B.A.) Societe A Responsabilite Limitee Dite: L-di or tripeptides possessing a biological activity for use in human and veterinary medicines, process for their obtention and medicines containing them

Also Published As

Publication number Publication date
CA1065857A (en) 1979-11-06
IL48835A (en) 1979-05-31
DE2602193C2 (en) 1982-07-08
DE2602193A1 (en) 1976-07-29
ATA49276A (en) 1980-03-15
SE424328B (en) 1982-07-12
BR7600449A (en) 1976-08-31
JPS598278B2 (en) 1984-02-23
DOP1976002544A (en) 1982-11-29
FR2298335B1 (en) 1980-06-20
FI61032C (en) 1982-05-10
DD123756A5 (en) 1977-01-12
IL48835A0 (en) 1976-03-31
DK143755B (en) 1981-10-05
NO146429C (en) 1982-09-29
LU74249A1 (en) 1977-08-03
SE7600731L (en) 1976-07-28
NL177021B (en) 1985-02-18
SE7710045L (en) 1977-09-07
PH16560A (en) 1983-11-18
PL99096B1 (en) 1978-06-30
FI61032B (en) 1982-01-29
US4016148A (en) 1977-04-05
ES444622A1 (en) 1977-10-16
FI760084A (en) 1976-07-28
JPS5198223A (en) 1976-08-30
CH624965A5 (en) 1981-08-31
CH623829A5 (en) 1981-06-30
AU502919B2 (en) 1979-08-16
IE42466L (en) 1976-07-27
NO146429B (en) 1982-06-21
HU176800B (en) 1981-05-28
GR58609B (en) 1977-11-10
DK29576A (en) 1976-07-28
IE42466B1 (en) 1980-08-13
NL7600539A (en) 1976-07-29
AR218850A1 (en) 1980-07-15
DK143755C (en) 1982-03-22
AU1035476A (en) 1977-07-21
NL177021C (en) 1985-07-16
PT64743A (en) 1976-02-01
PT64743B (en) 1978-01-04
NO760231L (en) 1976-07-28
AT359217B (en) 1980-10-27

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Legal Events

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ST Notification of lapse