ES435498A1 - Procedure for the preparation of 1- (3,5-dihydroxypenyl) -1-hydroxy-2- (1-methyl-2- (4-hydroxypenyl) -etil) -aminoethane. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of 1- (3,5-dihydroxypenyl) -1-hydroxy-2- (1-methyl-2- (4-hydroxypenyl) -etil) -aminoethane. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES435498A1
ES435498A1 ES435498A ES435498A ES435498A1 ES 435498 A1 ES435498 A1 ES 435498A1 ES 435498 A ES435498 A ES 435498A ES 435498 A ES435498 A ES 435498A ES 435498 A1 ES435498 A1 ES 435498A1
Authority
ES
Spain
Prior art keywords
aminoethane
hydroxy
methyl
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES435498A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of ES435498A1 publication Critical patent/ES435498A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/56—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
    • C07C215/58—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C07C215/60—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain the chain having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Novel process for the preparation of 1-(3,5-dihydroxyphenyl)-1-hydroxy-2-[1-methyl-2-(4-hydroxyphenyl)-ethy l-aminoethane of the formula I < IMAGE > if appropriate in the form of the diastereomers, and of the corresponding acid addition salts, in which a compound of the formula II < IMAGE > in which R1 denotes an optionally substituted arylmethyl radical and R2 denotes hydrogen or an optionally substituted arylmethyl radical, is reduced with sodium borohydride, and the protective groups are eliminated from the resulting reaction product. Resolution to give the diastereomeric pairs of antipodes can be effected before or after elimination of the protective groups. Compared with the known processes, the novel process is distinguished by the simplicity of the procedure, surprisingly high yields and the purity of the end product.
ES435498A 1974-03-19 1975-03-11 Procedure for the preparation of 1- (3,5-dihydroxypenyl) -1-hydroxy-2- (1-methyl-2- (4-hydroxypenyl) -etil) -aminoethane. (Machine-translation by Google Translate, not legally binding) Expired ES435498A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2413102A DE2413102C3 (en) 1974-03-19 1974-03-19 Process for the production of l- (3,5-dihydroxyphenyl) -t-hydroxy-2-square brackets on 1-methyl-2- (4-hydroxyphenyl) -ethyl] -aminoethane

Publications (1)

Publication Number Publication Date
ES435498A1 true ES435498A1 (en) 1976-12-01

Family

ID=5910493

Family Applications (1)

Application Number Title Priority Date Filing Date
ES435498A Expired ES435498A1 (en) 1974-03-19 1975-03-11 Procedure for the preparation of 1- (3,5-dihydroxypenyl) -1-hydroxy-2- (1-methyl-2- (4-hydroxypenyl) -etil) -aminoethane. (Machine-translation by Google Translate, not legally binding)

Country Status (13)

Country Link
JP (1) JPS50131936A (en)
AT (1) AT339884B (en)
BG (1) BG27075A3 (en)
CH (1) CH607993A5 (en)
CS (1) CS181290B2 (en)
DE (1) DE2413102C3 (en)
DK (1) DK136184C (en)
ES (1) ES435498A1 (en)
FI (1) FI62528C (en)
HU (1) HU169834B (en)
NO (1) NO140378C (en)
SE (1) SE423091B (en)
YU (1) YU37111B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5256217A (en) * 1975-11-01 1977-05-09 Nissan Motor Co Ltd Exhaust purifying system for internal combustion engine
CA1145766A (en) * 1978-07-03 1983-05-03 Jack Mills Optically active phenethanolamines and method for increasing cardiac contractility
CH653322A5 (en) * 1982-12-01 1985-12-31 Siegfried Ag METHOD FOR PRODUCING PHENYLETHANOLAMINES.
WO2014108449A1 (en) 2013-01-08 2014-07-17 Atrogi Ab A screening method, a kit, a method of treatment and a compound for use in a method of treatment
GB201714745D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714734D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714740D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714736D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB202205895D0 (en) 2022-04-22 2022-06-08 Atrogi Ab New medical uses

Also Published As

Publication number Publication date
DK136184C (en) 1978-03-20
FI750725A (en) 1975-09-20
ATA153975A (en) 1977-03-15
SE7503083L (en) 1975-09-22
BG27075A3 (en) 1979-08-15
AT339884B (en) 1977-11-10
DE2413102C3 (en) 1980-09-11
NO750922L (en) 1975-09-22
YU67375A (en) 1983-04-27
JPS50131936A (en) 1975-10-18
SE423091B (en) 1982-04-13
NO140378C (en) 1979-08-22
DK110175A (en) 1975-09-20
DE2413102A1 (en) 1975-10-09
CH607993A5 (en) 1978-12-15
DK136184B (en) 1977-08-29
YU37111B (en) 1984-08-31
NO140378B (en) 1979-05-14
HU169834B (en) 1977-02-28
DE2413102B2 (en) 1980-01-17
CS181290B2 (en) 1978-03-31
FI62528C (en) 1983-01-10
FI62528B (en) 1982-09-30

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