ES436362A1 - (3beta-hydroxy-2beta-(substituted-1-alkenyl)-5-oxo-1alpha-cyclopentyl)heptanoic acids - Google Patents

(3beta-hydroxy-2beta-(substituted-1-alkenyl)-5-oxo-1alpha-cyclopentyl)heptanoic acids

Info

Publication number
ES436362A1
ES436362A1 ES436362A ES436362A ES436362A1 ES 436362 A1 ES436362 A1 ES 436362A1 ES 436362 A ES436362 A ES 436362A ES 436362 A ES436362 A ES 436362A ES 436362 A1 ES436362 A1 ES 436362A1
Authority
ES
Spain
Prior art keywords
atoms
denotes
alkyl radical
hydroxy
2beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES436362A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of ES436362A1 publication Critical patent/ES436362A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

Prostanoic acid derivatives of the following formula < IMAGE > are prepared, in which R' denotes an alkyl radical having 1-7 C atoms and R'' denotes a straight-chain alkyl radical having 6-9 C atoms. These compounds are obtained by reacting an appropriate ketone, which is optionally protected on the hydroxy group, with an organometallic compound of the formula R'M or R''M in which M denotes lithium or magnesium halogen to introduce the substituent R' or R'' and optionally subsequently removing the protective group. The compound of the formula I, which is present as the free acid, can be converted into alkyl esters having 1-7 C atoms in the alkyl radical. On account of their antifertility properties, the prostanoic acid derivatives are utilisable pharmaceutical agents.
ES436362A 1974-04-08 1975-04-07 (3beta-hydroxy-2beta-(substituted-1-alkenyl)-5-oxo-1alpha-cyclopentyl)heptanoic acids Expired ES436362A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45879974A 1974-04-08 1974-04-08

Publications (1)

Publication Number Publication Date
ES436362A1 true ES436362A1 (en) 1977-01-01

Family

ID=23822127

Family Applications (1)

Application Number Title Priority Date Filing Date
ES436362A Expired ES436362A1 (en) 1974-04-08 1975-04-07 (3beta-hydroxy-2beta-(substituted-1-alkenyl)-5-oxo-1alpha-cyclopentyl)heptanoic acids

Country Status (14)

Country Link
JP (1) JPS5835183B2 (en)
AT (1) AT348154B (en)
BE (1) BE827694A (en)
CA (1) CA1071625A (en)
CH (1) CH609971A5 (en)
DE (1) DE2515115A1 (en)
DK (1) DK147075A (en)
ES (1) ES436362A1 (en)
FR (1) FR2266500B1 (en)
GB (1) GB1496716A (en)
IE (1) IE41470B1 (en)
NL (1) NL7504104A (en)
SE (1) SE420998B (en)
ZA (1) ZA752183B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60102774U (en) * 1983-12-14 1985-07-13 ソニー株式会社 floppy disc cassette
JPS60106272U (en) * 1983-12-24 1985-07-19 ソニー株式会社 floppy disc cassette
JPS60106271U (en) * 1983-12-24 1985-07-19 ソニー株式会社 floppy disc cassette
JPS60140266U (en) * 1984-02-25 1985-09-17 ソニー株式会社 magnetic disk device
JPS6121075U (en) * 1984-07-07 1986-02-06 ティーディーケイ株式会社 disk cartridge

Also Published As

Publication number Publication date
NL7504104A (en) 1975-10-10
IE41470L (en) 1975-10-08
CH609971A5 (en) 1979-03-30
DK147075A (en) 1975-10-09
SE7503928L (en) 1975-10-09
FR2266500A1 (en) 1975-10-31
BE827694A (en) 1975-10-08
JPS5835183B2 (en) 1983-08-01
GB1496716A (en) 1977-12-30
IE41470B1 (en) 1980-01-16
FR2266500B1 (en) 1978-07-28
SE420998B (en) 1981-11-16
ATA261475A (en) 1978-06-15
AU7990675A (en) 1976-10-14
ZA752183B (en) 1976-06-30
DE2515115A1 (en) 1975-10-16
AT348154B (en) 1979-02-12
JPS50137960A (en) 1975-11-01
CA1071625A (en) 1980-02-12

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