GB1496716A - (3beta-hydroxy-2beta-(substituted-1-alkenyl)-5-oxo-1alpha-cyclopentyl)heptanoic acids - Google Patents

(3beta-hydroxy-2beta-(substituted-1-alkenyl)-5-oxo-1alpha-cyclopentyl)heptanoic acids

Info

Publication number
GB1496716A
GB1496716A GB14093/75A GB1409375A GB1496716A GB 1496716 A GB1496716 A GB 1496716A GB 14093/75 A GB14093/75 A GB 14093/75A GB 1409375 A GB1409375 A GB 1409375A GB 1496716 A GB1496716 A GB 1496716A
Authority
GB
United Kingdom
Prior art keywords
atoms
denotes
alkyl radical
hydroxy
2beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB14093/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of GB1496716A publication Critical patent/GB1496716A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Prostanoic acid derivatives of the following formula <IMAGE> are prepared, in which R' denotes an alkyl radical having 1-7 C atoms and R'' denotes a straight-chain alkyl radical having 6-9 C atoms. These compounds are obtained by reacting an appropriate ketone, which is optionally protected on the hydroxy group, with an organometallic compound of the formula R'M or R''M in which M denotes lithium or magnesium halogen to introduce the substituent R' or R'' and optionally subsequently removing the protective group. The compound of the formula I, which is present as the free acid, can be converted into alkyl esters having 1-7 C atoms in the alkyl radical. On account of their antifertility properties, the prostanoic acid derivatives are utilisable pharmaceutical agents.
GB14093/75A 1974-04-08 1975-04-07 (3beta-hydroxy-2beta-(substituted-1-alkenyl)-5-oxo-1alpha-cyclopentyl)heptanoic acids Expired GB1496716A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45879974A 1974-04-08 1974-04-08

Publications (1)

Publication Number Publication Date
GB1496716A true GB1496716A (en) 1977-12-30

Family

ID=23822127

Family Applications (1)

Application Number Title Priority Date Filing Date
GB14093/75A Expired GB1496716A (en) 1974-04-08 1975-04-07 (3beta-hydroxy-2beta-(substituted-1-alkenyl)-5-oxo-1alpha-cyclopentyl)heptanoic acids

Country Status (14)

Country Link
JP (1) JPS5835183B2 (en)
AT (1) AT348154B (en)
BE (1) BE827694A (en)
CA (1) CA1071625A (en)
CH (1) CH609971A5 (en)
DE (1) DE2515115A1 (en)
DK (1) DK147075A (en)
ES (1) ES436362A1 (en)
FR (1) FR2266500B1 (en)
GB (1) GB1496716A (en)
IE (1) IE41470B1 (en)
NL (1) NL7504104A (en)
SE (1) SE420998B (en)
ZA (1) ZA752183B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60102774U (en) * 1983-12-14 1985-07-13 ソニー株式会社 floppy disc cassette
JPS60106272U (en) * 1983-12-24 1985-07-19 ソニー株式会社 floppy disc cassette
JPS60106271U (en) * 1983-12-24 1985-07-19 ソニー株式会社 floppy disc cassette
JPS60140266U (en) * 1984-02-25 1985-09-17 ソニー株式会社 magnetic disk device
JPS6121075U (en) * 1984-07-07 1986-02-06 ティーディーケイ株式会社 disk cartridge

Also Published As

Publication number Publication date
ATA261475A (en) 1978-06-15
CH609971A5 (en) 1979-03-30
IE41470B1 (en) 1980-01-16
SE7503928L (en) 1975-10-09
JPS5835183B2 (en) 1983-08-01
SE420998B (en) 1981-11-16
FR2266500B1 (en) 1978-07-28
DK147075A (en) 1975-10-09
ZA752183B (en) 1976-06-30
CA1071625A (en) 1980-02-12
AT348154B (en) 1979-02-12
DE2515115A1 (en) 1975-10-16
JPS50137960A (en) 1975-11-01
NL7504104A (en) 1975-10-10
FR2266500A1 (en) 1975-10-31
IE41470L (en) 1975-10-08
BE827694A (en) 1975-10-08
ES436362A1 (en) 1977-01-01
AU7990675A (en) 1976-10-14

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee