ES435690A2 - N-substituted 1,2,4-triazoles - Google Patents

N-substituted 1,2,4-triazoles

Info

Publication number
ES435690A2
ES435690A2 ES435690A ES435690A ES435690A2 ES 435690 A2 ES435690 A2 ES 435690A2 ES 435690 A ES435690 A ES 435690A ES 435690 A ES435690 A ES 435690A ES 435690 A2 ES435690 A2 ES 435690A2
Authority
ES
Spain
Prior art keywords
ether
substituted
formula
see formula
unsaturated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES435690A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Valeant Pharmaceuticals International Inc USA
Original Assignee
ICN Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/452,213 external-priority patent/US3991078A/en
Application filed by ICN Pharmaceuticals Inc filed Critical ICN Pharmaceuticals Inc
Publication of ES435690A2 publication Critical patent/ES435690A2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals

Abstract

Improvements introduced in the object of the main patent no. 424,201 by: "Procedure for obtaining 1,2,4-triazol-3-carboxamide as antiviral agents", characterized in that to form N-substituted 1,2,4-triacoles unstable acids the acid catalyst addition reaction is performed under anhydrous conditions of 1,2,4-triazole of the formula **(See formula)** wherein R1 is a cyano, carboxamido, thiocarboxamido or alkylcarboxylate group with an α-unsaturated non-glyocosidic ether to form compounds of the structures: **(See formula)** wherein G is a moiety of 1- (alpha; -alkoxyalkyl) corresponding to the unsaturated analog of said ether. (Machine-translation by Google Translate, not legally binding)
ES435690A 1974-03-18 1975-03-17 N-substituted 1,2,4-triazoles Expired ES435690A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/452,213 US3991078A (en) 1971-06-01 1974-03-18 N-substituted 1,2,4-triazoles

Publications (1)

Publication Number Publication Date
ES435690A2 true ES435690A2 (en) 1977-02-01

Family

ID=23795554

Family Applications (1)

Application Number Title Priority Date Filing Date
ES435690A Expired ES435690A2 (en) 1974-03-18 1975-03-17 N-substituted 1,2,4-triazoles

Country Status (13)

Country Link
JP (2) JPS50154252A (en)
AR (1) AR207138A1 (en)
BE (2) BE826777R (en)
CA (1) CA1050028A (en)
DE (1) DE2511829A1 (en)
DK (1) DK154343C (en)
ES (1) ES435690A2 (en)
FR (1) FR2264533B2 (en)
GB (1) GB1490272A (en)
NL (1) NL7503209A (en)
SE (1) SE7502994L (en)
YU (1) YU42138B (en)
ZA (1) ZA751663B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02106421U (en) * 1989-02-07 1990-08-23
RU2624018C2 (en) * 2016-09-26 2017-06-30 Федеральное государственное бюджетное учреждение науки Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова РАН (ИБХ РАН) 5-(tetrahydrofuran-2-yl)-1,2,4-triazole-3-carboxylic acid amide with antiviral activity, and method for production

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3798209A (en) * 1971-06-01 1974-03-19 Icn Pharmaceuticals 1,2,4-triazole nucleosides

Also Published As

Publication number Publication date
BE826777R (en) 1975-07-16
YU42138B (en) 1988-06-30
DK154343B (en) 1988-11-07
CA1050028A (en) 1979-03-06
BE904149Q (en) 1986-05-15
ZA751663B (en) 1976-02-25
DK154343C (en) 1989-05-22
DE2511829A1 (en) 1975-09-25
GB1490272A (en) 1977-10-26
DK106475A (en) 1975-09-19
JPS50154252A (en) 1975-12-12
FR2264533A2 (en) 1975-10-17
AU7914475A (en) 1976-09-23
YU65875A (en) 1983-01-21
JPS59144773A (en) 1984-08-18
DE2511829C2 (en) 1989-06-22
FR2264533B2 (en) 1978-09-01
AR207138A1 (en) 1976-09-15
SE7502994L (en) 1975-09-19
NL7503209A (en) 1975-09-22
JPS6133822B2 (en) 1986-08-04

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Legal Events

Date Code Title Description
FD2A Announcement of lapse in spain

Effective date: 20170705