ES410009A1 - Process for preparing 7-acylamino-3-substituted-3-cephem-4- carboxylic acid derivatives - Google Patents

Process for preparing 7-acylamino-3-substituted-3-cephem-4- carboxylic acid derivatives

Info

Publication number
ES410009A1
ES410009A1 ES410009A ES410009A ES410009A1 ES 410009 A1 ES410009 A1 ES 410009A1 ES 410009 A ES410009 A ES 410009A ES 410009 A ES410009 A ES 410009A ES 410009 A1 ES410009 A1 ES 410009A1
Authority
ES
Spain
Prior art keywords
react
substituted
resulting compound
formula
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES410009A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of ES410009A1 publication Critical patent/ES410009A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

A process for the preparation of 3-substituted 7-acylamino-3-cephem-4-carboxylic acid derivatives of the following formula ** formula ** where R1 is a hydrogen atom, a substituted or unsubstituted heterocyclo-thio group, or an alkylthio group, R2 is an acyl group and R4 is a hydrogen atom or an ester moiety, and their pharmaceutically acceptable salts, the procedure of which is to react a compound of formula ** formula ** where R1, R2 and R4 are those defined above and R3 is an acyl group, or its salt with a silylating agent, react the resulting compound with an iminohalogenating agent, react the resulting compound with an iminoeterifying agent, react the resulting compound with an acylating agent, and then hydrolyze the resulting compound. (Machine-translation by Google Translate, not legally binding)
ES410009A 1971-12-23 1972-12-23 Process for preparing 7-acylamino-3-substituted-3-cephem-4- carboxylic acid derivatives Expired ES410009A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP25177271 1971-12-23

Publications (1)

Publication Number Publication Date
ES410009A1 true ES410009A1 (en) 1975-12-01

Family

ID=17227685

Family Applications (1)

Application Number Title Priority Date Filing Date
ES410009A Expired ES410009A1 (en) 1971-12-23 1972-12-23 Process for preparing 7-acylamino-3-substituted-3-cephem-4- carboxylic acid derivatives

Country Status (4)

Country Link
DK (1) DK154889C (en)
ES (1) ES410009A1 (en)
GB (1) GB1414324A (en)
SE (1) SE428693B (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1953861C2 (en) * 1969-10-25 1982-12-23 Fujisawa Pharmaceutical Co., Ltd., Osaka 7-tetrazolylacetamido-3-thiomethyl-3-cephem-4-carboxylic acids
BE758587A (en) * 1969-11-17 1971-05-06 Fujisawa Pharmaceutical Co PROCESS FOR THE PREPARATION OF 7-AMINOCEPHALOSPORANIC ACID DERIVATIVES AND NEW PRODUCTS THUS OBTAINED

Also Published As

Publication number Publication date
DK154889B (en) 1989-01-02
DK154889C (en) 1989-06-12
GB1414324A (en) 1975-11-19
SE428693B (en) 1983-07-18

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19950223