GB2017103A - Cephalosporin analogues - Google Patents
Cephalosporin analoguesInfo
- Publication number
- GB2017103A GB2017103A GB7910507A GB7910507A GB2017103A GB 2017103 A GB2017103 A GB 2017103A GB 7910507 A GB7910507 A GB 7910507A GB 7910507 A GB7910507 A GB 7910507A GB 2017103 A GB2017103 A GB 2017103A
- Authority
- GB
- United Kingdom
- Prior art keywords
- cephalosporin analogues
- analogues
- cephalosporin
- novel
- acyloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229930186147 Cephalosporin Natural products 0.000 title abstract 3
- 229940124587 cephalosporin Drugs 0.000 title abstract 3
- 150000001780 cephalosporins Chemical class 0.000 title abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
- C07D463/16—Nitrogen atoms
- C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/568—Four-membered rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel antibiotic cephalosporin analogues are provided being compounds of the formula <IMAGE> where X is acyl, R<1> is H or an esterifying group and R<2> is H, alkyl or acyloxy, and their pharmaceutically acceptable salts. Also disclosed are pharmaceutical compositions containing the novel cephalosporin analogues and methods for preparing them.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3469678A JPS54128591A (en) | 1978-03-25 | 1978-03-25 | Cephalosporin analog |
JP12240278A JPS5549375A (en) | 1978-10-04 | 1978-10-04 | Cephalosporin analog |
JP12702778A JPS5553290A (en) | 1978-10-16 | 1978-10-16 | Cephalosporin analogue |
JP13307178A JPS5559185A (en) | 1978-10-28 | 1978-10-28 | Cephalosporin analog |
JP53162007A JPS5936915B2 (en) | 1978-12-26 | 1978-12-26 | Cephalosporin analogs |
JP16200678A JPS5587789A (en) | 1978-12-26 | 1978-12-26 | Sephalosporin analog |
JP54008409A JPS5936917B2 (en) | 1979-01-27 | 1979-01-27 | Cephalosporin analogs |
Publications (2)
Publication Number | Publication Date |
---|---|
GB2017103A true GB2017103A (en) | 1979-10-03 |
GB2017103B GB2017103B (en) | 1982-09-08 |
Family
ID=27563451
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB7910507A Expired GB2017103B (en) | 1978-03-25 | 1979-03-26 | Cephalosporin analogues |
Country Status (10)
Country | Link |
---|---|
AU (1) | AU527128B2 (en) |
CA (1) | CA1178956A (en) |
CH (1) | CH640855A5 (en) |
DE (1) | DE2911787C2 (en) |
DK (1) | DK120179A (en) |
FR (1) | FR2420538A1 (en) |
GB (1) | GB2017103B (en) |
IT (1) | IT1165187B (en) |
NL (1) | NL7902321A (en) |
NO (1) | NO790956L (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0014476A1 (en) * | 1979-02-10 | 1980-08-20 | Kyowa Hakko Kogyo Co., Ltd | Optically active acylated cephalosporin analogs, processes for their preparation and pharmaceutical compositions comprising them |
US4708956A (en) * | 1985-12-12 | 1987-11-24 | Kyowa Hakko Kogyo Co., Ltd. | 3-position halogenated cephalosporin analogs and pharmaceutical compositions |
US4734494A (en) * | 1979-11-14 | 1988-03-29 | Kyowa Hakko Kogyo Co., Ltd. | Optically active 3-halo carbacephems |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0791291B2 (en) * | 1985-12-30 | 1995-10-04 | イ−ライ・リリ−・アンド・カンパニ− | 1-carbacef allosporin antibiotic |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2714880A1 (en) * | 1977-04-02 | 1978-10-26 | Hoechst Ag | CEPHEMDER DERIVATIVES AND PROCESS FOR THEIR PRODUCTION |
US4140688A (en) * | 1978-04-03 | 1979-02-20 | Smithkline Corporation | Tricyclic (azeto-isoquinoline) β-lactams |
-
1979
- 1979-03-21 NO NO790956A patent/NO790956L/en unknown
- 1979-03-23 CA CA000324074A patent/CA1178956A/en not_active Expired
- 1979-03-23 DK DK120179A patent/DK120179A/en not_active Application Discontinuation
- 1979-03-23 FR FR7907415A patent/FR2420538A1/en active Granted
- 1979-03-23 AU AU45368/79A patent/AU527128B2/en not_active Ceased
- 1979-03-23 NL NL7902321A patent/NL7902321A/en not_active Application Discontinuation
- 1979-03-26 GB GB7910507A patent/GB2017103B/en not_active Expired
- 1979-03-26 CH CH279079A patent/CH640855A5/en not_active IP Right Cessation
- 1979-03-26 DE DE2911787A patent/DE2911787C2/en not_active Expired
- 1979-03-26 IT IT67623/79A patent/IT1165187B/en active
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0014476A1 (en) * | 1979-02-10 | 1980-08-20 | Kyowa Hakko Kogyo Co., Ltd | Optically active acylated cephalosporin analogs, processes for their preparation and pharmaceutical compositions comprising them |
US4734494A (en) * | 1979-11-14 | 1988-03-29 | Kyowa Hakko Kogyo Co., Ltd. | Optically active 3-halo carbacephems |
US4708956A (en) * | 1985-12-12 | 1987-11-24 | Kyowa Hakko Kogyo Co., Ltd. | 3-position halogenated cephalosporin analogs and pharmaceutical compositions |
Also Published As
Publication number | Publication date |
---|---|
DE2911787A1 (en) | 1979-09-27 |
CA1178956A (en) | 1984-12-04 |
NL7902321A (en) | 1979-09-27 |
GB2017103B (en) | 1982-09-08 |
FR2420538A1 (en) | 1979-10-19 |
NO790956L (en) | 1979-09-26 |
AU4536879A (en) | 1979-10-04 |
AU527128B2 (en) | 1983-02-17 |
DE2911787C2 (en) | 1985-06-05 |
IT1165187B (en) | 1987-04-22 |
FR2420538B1 (en) | 1982-10-15 |
DK120179A (en) | 1979-09-26 |
IT7967623A0 (en) | 1979-03-26 |
CH640855A5 (en) | 1984-01-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19930326 |