GB1521073A - Cephalosporin compounds - Google Patents
Cephalosporin compoundsInfo
- Publication number
- GB1521073A GB1521073A GB31598/75A GB3159875A GB1521073A GB 1521073 A GB1521073 A GB 1521073A GB 31598/75 A GB31598/75 A GB 31598/75A GB 3159875 A GB3159875 A GB 3159875A GB 1521073 A GB1521073 A GB 1521073A
- Authority
- GB
- United Kingdom
- Prior art keywords
- image
- formula
- reaction
- hand
- cephalosporin compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel cephalosporins of the general formula <IMAGE> are obtained by reaction of a 3-acetoxymethylcephalosporin of the formula <IMAGE> with a triazinylthio derivative of the formula <IMAGE> The substituents are defined in Claim 1. If necessary, the amino and/or carboxyl groups are intermediately protected and, if it is desired, the compounds obtained according to the invention are acylated by the known processes. The reaction is preferably carried out in polar solvents, e.g. water. These novel cephalosporins are to be used on the one hand as medicines having antibiotic activity or on the other hand as intermediates in the preparation of antibiotics.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49414874A | 1974-08-02 | 1974-08-02 | |
US58392475A | 1975-06-10 | 1975-06-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1521073A true GB1521073A (en) | 1978-08-09 |
Family
ID=27051316
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB31598/75A Expired GB1521073A (en) | 1974-08-02 | 1975-07-29 | Cephalosporin compounds |
Country Status (22)
Country | Link |
---|---|
JP (1) | JPS6123195B2 (en) |
AR (1) | AR210998A1 (en) |
AT (1) | AT347580B (en) |
BG (1) | BG26395A3 (en) |
CA (1) | CA1100129A (en) |
CH (1) | CH616683A5 (en) |
CS (1) | CS189716B2 (en) |
DD (1) | DD121114A5 (en) |
DE (1) | DE2534071A1 (en) |
DK (1) | DK343275A (en) |
FR (1) | FR2280381A1 (en) |
GB (1) | GB1521073A (en) |
HU (1) | HU174130B (en) |
IE (1) | IE41590B1 (en) |
IL (1) | IL47802A (en) |
NL (1) | NL7509053A (en) |
PH (1) | PH16078A (en) |
PL (1) | PL95607B1 (en) |
RO (1) | RO72980A (en) |
SE (1) | SE426830B (en) |
SU (1) | SU755200A3 (en) |
YU (1) | YU197075A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4298605A (en) | 1978-06-22 | 1981-11-03 | Chugai Seiyaku Kabushiki Kaisha | Cephalosporin derivatives |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4348518A (en) | 1974-05-05 | 1982-09-07 | Hoffmann-La Roche Inc. | Cephalosporins |
JPS50141233U (en) * | 1974-05-08 | 1975-11-20 | ||
CY1196A (en) * | 1977-03-07 | 1983-12-31 | Lilly Co Eli | Cephalosporin synthesis |
NL7805715A (en) * | 1977-06-03 | 1978-12-05 | Hoffmann La Roche | METHOD FOR PREPARING ACYL DERIVATIVES. |
US4200745A (en) * | 1977-12-20 | 1980-04-29 | Eli Lilly And Company | 7[2-(2-Aminothiazol-4-yl)-2-alkoxyimino]acetamido 3[4-alkyl-5-oxo-6-hydroxy-3,4 dihydro 1,2,4-triazin 3-yl]thio methyl cephalosporins |
MC1259A1 (en) * | 1978-05-30 | 1980-01-14 | Hoffmann La Roche | ACYL DERIVATIVES |
FI782683A (en) * | 1978-07-19 | 1980-01-20 | Hoffmann La Roche | KEFALOSPORINESTRAR OCH -ESTRAR |
FR2474030A1 (en) * | 1980-01-17 | 1981-07-24 | Rhone Poulenc Ind | 2-Mercapto-1,2,4-triazine, 1,3,4-triazole or tetrazole derivs. - useful as intermediates for antibacterial cephalosporin(s) |
NL8100089A (en) | 1980-01-17 | 1981-08-17 | Rhone Poulenc Ind | NEW THIOLS AND THEIR PREPARATION. |
FR2494278A1 (en) * | 1980-11-20 | 1982-05-21 | Rhone Poulenc Ind | NEW DERIVATIVES OF CEPHALOSPORIN, THEIR PREPARATIONS AND THE MEDICINAL PRODUCTS CONTAINING THEM |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5116436B1 (en) * | 1971-05-31 | 1976-05-24 |
-
1975
- 1975-07-24 CA CA232,136A patent/CA1100129A/en not_active Expired
- 1975-07-25 FR FR7523346A patent/FR2280381A1/en active Granted
- 1975-07-25 RO RO7593489A patent/RO72980A/en unknown
- 1975-07-25 CS CS755262A patent/CS189716B2/en unknown
- 1975-07-25 IL IL47802A patent/IL47802A/en unknown
- 1975-07-28 SE SE7508570A patent/SE426830B/en not_active IP Right Cessation
- 1975-07-29 DK DK343275A patent/DK343275A/en not_active Application Discontinuation
- 1975-07-29 JP JP50092486A patent/JPS6123195B2/ja not_active Expired
- 1975-07-29 IE IE1693/75A patent/IE41590B1/en unknown
- 1975-07-29 SU SU752163060A patent/SU755200A3/en active
- 1975-07-29 GB GB31598/75A patent/GB1521073A/en not_active Expired
- 1975-07-29 NL NL7509053A patent/NL7509053A/en not_active Application Discontinuation
- 1975-07-30 DE DE19752534071 patent/DE2534071A1/en not_active Withdrawn
- 1975-07-31 AR AR259862A patent/AR210998A1/en active
- 1975-07-31 AT AT594075A patent/AT347580B/en active
- 1975-07-31 CH CH1005975A patent/CH616683A5/en not_active IP Right Cessation
- 1975-08-01 PL PL1975182474A patent/PL95607B1/en unknown
- 1975-08-01 DD DD187628A patent/DD121114A5/xx unknown
- 1975-08-01 YU YU01970/75A patent/YU197075A/en unknown
- 1975-08-01 HU HU75EI637A patent/HU174130B/en unknown
- 1975-08-02 BG BG7530722A patent/BG26395A3/xx unknown
-
1977
- 1977-08-26 PH PH20172A patent/PH16078A/en unknown
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4298605A (en) | 1978-06-22 | 1981-11-03 | Chugai Seiyaku Kabushiki Kaisha | Cephalosporin derivatives |
US4301161A (en) | 1978-06-22 | 1981-11-17 | Chugai Seiyaku Kabushiki Kaisha | Cephalosporin derivatives |
US4328224A (en) | 1978-06-22 | 1982-05-04 | Chugai Seiyaku Kabushiki Kaisha | Cephalosporin derivatives |
US4341776A (en) | 1978-06-22 | 1982-07-27 | Chugai Seiyaku Kabushiki Kaisha | Cephalosporin derivatives |
Also Published As
Publication number | Publication date |
---|---|
IE41590B1 (en) | 1980-02-13 |
PH16078A (en) | 1983-06-20 |
YU197075A (en) | 1982-05-31 |
DK343275A (en) | 1976-02-03 |
DE2534071A1 (en) | 1976-02-12 |
CA1100129A (en) | 1981-04-28 |
SE7508570L (en) | 1976-02-03 |
JPS6123195B2 (en) | 1986-06-04 |
FR2280381A1 (en) | 1976-02-27 |
JPS5139693A (en) | 1976-04-02 |
DD121114A5 (en) | 1976-07-12 |
HU174130B (en) | 1979-11-28 |
SU755200A3 (en) | 1980-08-07 |
ATA594075A (en) | 1976-11-15 |
IE41590L (en) | 1976-02-02 |
NL7509053A (en) | 1976-02-04 |
IL47802A0 (en) | 1975-10-15 |
FR2280381B1 (en) | 1979-08-10 |
SE426830B (en) | 1983-02-14 |
CS189716B2 (en) | 1979-04-30 |
AT347580B (en) | 1979-01-10 |
AR210998A1 (en) | 1977-10-14 |
IL47802A (en) | 1980-05-30 |
RO72980A (en) | 1981-08-30 |
BG26395A3 (en) | 1979-03-15 |
PL95607B1 (en) | 1977-10-31 |
CH616683A5 (en) | 1980-04-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |