GB1521073A - Cephalosporin compounds - Google Patents

Cephalosporin compounds

Info

Publication number
GB1521073A
GB1521073A GB31598/75A GB3159875A GB1521073A GB 1521073 A GB1521073 A GB 1521073A GB 31598/75 A GB31598/75 A GB 31598/75A GB 3159875 A GB3159875 A GB 3159875A GB 1521073 A GB1521073 A GB 1521073A
Authority
GB
United Kingdom
Prior art keywords
image
formula
reaction
hand
cephalosporin compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB31598/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of GB1521073A publication Critical patent/GB1521073A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel cephalosporins of the general formula <IMAGE> are obtained by reaction of a 3-acetoxymethylcephalosporin of the formula <IMAGE> with a triazinylthio derivative of the formula <IMAGE> The substituents are defined in Claim 1. If necessary, the amino and/or carboxyl groups are intermediately protected and, if it is desired, the compounds obtained according to the invention are acylated by the known processes. The reaction is preferably carried out in polar solvents, e.g. water. These novel cephalosporins are to be used on the one hand as medicines having antibiotic activity or on the other hand as intermediates in the preparation of antibiotics.
GB31598/75A 1974-08-02 1975-07-29 Cephalosporin compounds Expired GB1521073A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49414874A 1974-08-02 1974-08-02
US58392475A 1975-06-10 1975-06-10

Publications (1)

Publication Number Publication Date
GB1521073A true GB1521073A (en) 1978-08-09

Family

ID=27051316

Family Applications (1)

Application Number Title Priority Date Filing Date
GB31598/75A Expired GB1521073A (en) 1974-08-02 1975-07-29 Cephalosporin compounds

Country Status (22)

Country Link
JP (1) JPS6123195B2 (en)
AR (1) AR210998A1 (en)
AT (1) AT347580B (en)
BG (1) BG26395A3 (en)
CA (1) CA1100129A (en)
CH (1) CH616683A5 (en)
CS (1) CS189716B2 (en)
DD (1) DD121114A5 (en)
DE (1) DE2534071A1 (en)
DK (1) DK343275A (en)
FR (1) FR2280381A1 (en)
GB (1) GB1521073A (en)
HU (1) HU174130B (en)
IE (1) IE41590B1 (en)
IL (1) IL47802A (en)
NL (1) NL7509053A (en)
PH (1) PH16078A (en)
PL (1) PL95607B1 (en)
RO (1) RO72980A (en)
SE (1) SE426830B (en)
SU (1) SU755200A3 (en)
YU (1) YU197075A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4298605A (en) 1978-06-22 1981-11-03 Chugai Seiyaku Kabushiki Kaisha Cephalosporin derivatives

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4348518A (en) 1974-05-05 1982-09-07 Hoffmann-La Roche Inc. Cephalosporins
JPS50141233U (en) * 1974-05-08 1975-11-20
CY1196A (en) * 1977-03-07 1983-12-31 Lilly Co Eli Cephalosporin synthesis
NL7805715A (en) * 1977-06-03 1978-12-05 Hoffmann La Roche METHOD FOR PREPARING ACYL DERIVATIVES.
US4200745A (en) * 1977-12-20 1980-04-29 Eli Lilly And Company 7[2-(2-Aminothiazol-4-yl)-2-alkoxyimino]acetamido 3[4-alkyl-5-oxo-6-hydroxy-3,4 dihydro 1,2,4-triazin 3-yl]thio methyl cephalosporins
MC1259A1 (en) * 1978-05-30 1980-01-14 Hoffmann La Roche ACYL DERIVATIVES
FI782683A (en) * 1978-07-19 1980-01-20 Hoffmann La Roche KEFALOSPORINESTRAR OCH -ESTRAR
FR2474030A1 (en) * 1980-01-17 1981-07-24 Rhone Poulenc Ind 2-Mercapto-1,2,4-triazine, 1,3,4-triazole or tetrazole derivs. - useful as intermediates for antibacterial cephalosporin(s)
NL8100089A (en) 1980-01-17 1981-08-17 Rhone Poulenc Ind NEW THIOLS AND THEIR PREPARATION.
FR2494278A1 (en) * 1980-11-20 1982-05-21 Rhone Poulenc Ind NEW DERIVATIVES OF CEPHALOSPORIN, THEIR PREPARATIONS AND THE MEDICINAL PRODUCTS CONTAINING THEM

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5116436B1 (en) * 1971-05-31 1976-05-24

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4298605A (en) 1978-06-22 1981-11-03 Chugai Seiyaku Kabushiki Kaisha Cephalosporin derivatives
US4301161A (en) 1978-06-22 1981-11-17 Chugai Seiyaku Kabushiki Kaisha Cephalosporin derivatives
US4328224A (en) 1978-06-22 1982-05-04 Chugai Seiyaku Kabushiki Kaisha Cephalosporin derivatives
US4341776A (en) 1978-06-22 1982-07-27 Chugai Seiyaku Kabushiki Kaisha Cephalosporin derivatives

Also Published As

Publication number Publication date
IE41590B1 (en) 1980-02-13
PH16078A (en) 1983-06-20
YU197075A (en) 1982-05-31
DK343275A (en) 1976-02-03
DE2534071A1 (en) 1976-02-12
CA1100129A (en) 1981-04-28
SE7508570L (en) 1976-02-03
JPS6123195B2 (en) 1986-06-04
FR2280381A1 (en) 1976-02-27
JPS5139693A (en) 1976-04-02
DD121114A5 (en) 1976-07-12
HU174130B (en) 1979-11-28
SU755200A3 (en) 1980-08-07
ATA594075A (en) 1976-11-15
IE41590L (en) 1976-02-02
NL7509053A (en) 1976-02-04
IL47802A0 (en) 1975-10-15
FR2280381B1 (en) 1979-08-10
SE426830B (en) 1983-02-14
CS189716B2 (en) 1979-04-30
AT347580B (en) 1979-01-10
AR210998A1 (en) 1977-10-14
IL47802A (en) 1980-05-30
RO72980A (en) 1981-08-30
BG26395A3 (en) 1979-03-15
PL95607B1 (en) 1977-10-31
CH616683A5 (en) 1980-04-15

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee