FR2388826A1 - PREPARATION OF 1-N- (O) AMINO-A-HYDROXYALKANOY) KANAMYCINS - Google Patents

PREPARATION OF 1-N- (O) AMINO-A-HYDROXYALKANOY) KANAMYCINS

Info

Publication number
FR2388826A1
FR2388826A1 FR7812589A FR7812589A FR2388826A1 FR 2388826 A1 FR2388826 A1 FR 2388826A1 FR 7812589 A FR7812589 A FR 7812589A FR 7812589 A FR7812589 A FR 7812589A FR 2388826 A1 FR2388826 A1 FR 2388826A1
Authority
FR
France
Prior art keywords
preparation
hydroxyalkanoy
kanamycins
amino
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7812589A
Other languages
French (fr)
Other versions
FR2388826B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of FR2388826A1 publication Critical patent/FR2388826A1/en
Application granted granted Critical
Publication of FR2388826B1 publication Critical patent/FR2388826B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne l'industrie pharmaceutique. Elle a pour objet un procédé de préparation de dérivés de kanamycine A ou B par acylation une kanamycine A ou B polysilylée à l'aide d'un dérivé acylant d'un acide de formule :The invention relates to the pharmaceutical industry. It relates to a process for the preparation of kanamycin A or B derivatives by acylation of a polysilylated kanamycin A or B using an acylating derivative of an acid of formula:

FR7812589A 1977-04-28 1978-04-27 PREPARATION OF 1-N- (O) AMINO-A-HYDROXYALKANOY) KANAMYCINS Granted FR2388826A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79180677A 1977-04-28 1977-04-28
US88858578A 1978-03-20 1978-03-20

Publications (2)

Publication Number Publication Date
FR2388826A1 true FR2388826A1 (en) 1978-11-24
FR2388826B1 FR2388826B1 (en) 1982-12-10

Family

ID=27121201

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7812589A Granted FR2388826A1 (en) 1977-04-28 1978-04-27 PREPARATION OF 1-N- (O) AMINO-A-HYDROXYALKANOY) KANAMYCINS
FR7812591A Granted FR2388827A1 (en) 1977-04-28 1978-04-27 PROCESS FOR THE PRODUCTION OF 1-N- (O-AMINO-A-HYDROXYALCANOYL) -AMINOGLYCOSIDIC ANTIBIOTICS

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR7812591A Granted FR2388827A1 (en) 1977-04-28 1978-04-27 PROCESS FOR THE PRODUCTION OF 1-N- (O-AMINO-A-HYDROXYALCANOYL) -AMINOGLYCOSIDIC ANTIBIOTICS

Country Status (27)

Country Link
JP (1) JPS53149951A (en)
AR (1) AR218910A1 (en)
AT (1) AT357675B (en)
CA (2) CA1105454A (en)
CH (1) CH639104A5 (en)
CS (1) CS207607B2 (en)
CY (1) CY1241A (en)
DE (2) DE2818822A1 (en)
DK (2) DK165450C (en)
EG (1) EG13710A (en)
ES (1) ES469303A1 (en)
FI (1) FI781288A (en)
FR (2) FR2388826A1 (en)
GB (1) GB1598294A (en)
HK (1) HK51484A (en)
IE (2) IE46945B1 (en)
IT (2) IT1156718B (en)
KE (1) KE3398A (en)
LU (1) LU79541A1 (en)
MY (1) MY8500528A (en)
NL (1) NL178790C (en)
NO (2) NO149635C (en)
PL (1) PL117307B1 (en)
PT (1) PT67959B (en)
SE (2) SE447259B (en)
SG (1) SG22884G (en)
YU (2) YU41590B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55306A (en) * 1978-04-28 1980-01-05 Bristol Myers Co Manufacture of 11nn*omegaaaminooalphaahydroxy alkanoyl**aminoglycoside antibiotic
CN1646484A (en) * 2002-02-19 2005-07-27 天藤制药株式会社 Lactic acid derivative
KR101296099B1 (en) 2007-11-21 2014-02-26 아카오젠, 인코포레이티드 Antibacterial aminoglycoside analogs
WO2010132759A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of dibekacin
WO2010132757A2 (en) * 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132760A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of tobramycin
WO2010132765A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132768A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of sisomicin

Also Published As

Publication number Publication date
CS207607B2 (en) 1981-08-31
AR218910A1 (en) 1980-07-15
LU79541A1 (en) 1978-11-28
CA1100953A (en) 1981-05-12
NL178790B (en) 1985-12-16
DK182978A (en) 1978-10-29
KE3398A (en) 1984-06-08
DE2818992A1 (en) 1978-11-23
IT7849137A0 (en) 1978-04-28
SE7804973L (en) 1978-10-29
IE780841L (en) 1978-10-28
AT357675B (en) 1980-07-25
NO149635C (en) 1984-05-23
CY1241A (en) 1984-06-29
FR2388827B1 (en) 1982-07-09
DK183078A (en) 1978-10-29
YU102578A (en) 1983-01-21
PT67959A (en) 1978-05-01
JPS53149951A (en) 1978-12-27
DK165450B (en) 1992-11-30
DE2818822C2 (en) 1989-01-26
PL206457A1 (en) 1980-03-24
YU41590B (en) 1987-12-31
NL178790C (en) 1986-05-16
GB1598294A (en) 1981-09-16
NO781437L (en) 1978-10-31
CH639104A5 (en) 1983-10-31
DK165450C (en) 1993-04-13
IE780842L (en) 1978-10-28
ES469303A1 (en) 1979-09-16
JPS5721277B2 (en) 1982-05-06
DE2818992C2 (en) 1988-03-17
EG13710A (en) 1982-09-30
IT7849136A0 (en) 1978-04-28
YU102478A (en) 1982-10-31
DE2818822A1 (en) 1978-11-09
IE46945B1 (en) 1983-11-16
SE447259B (en) 1986-11-03
IE47271B1 (en) 1984-02-08
CA1105454A (en) 1981-07-21
ATA312778A (en) 1979-12-15
NO154697C (en) 1986-12-03
IT1156718B (en) 1987-02-04
MY8500528A (en) 1985-12-31
DK172543B1 (en) 1998-12-07
IT1105500B (en) 1985-11-04
PL117307B1 (en) 1981-07-31
NL7804503A (en) 1978-10-31
SG22884G (en) 1985-01-04
FI781288A (en) 1978-10-29
FR2388826B1 (en) 1982-12-10
SE8305538D0 (en) 1983-10-07
PT67959B (en) 1980-03-05
NO149635B (en) 1984-02-13
NO154697B (en) 1986-08-25
NO831197L (en) 1978-10-31
SE8305538L (en) 1983-10-07
HK51484A (en) 1984-06-22
FR2388827A1 (en) 1978-11-24
SE461148B (en) 1990-01-15

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Legal Events

Date Code Title Description
CC Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990)

Free format text: 92C0104, 920429

CD Change of name or company name
CB Supplementary protection certificate (spc) granted (law of 25 june 1990)

Free format text: 92C0104, 780427

CL Concession to grant licences