DK3107899T3 - Mitokondriel aldehyddehydrogenase 2 (aldh2)-bindende polycykliske amider og anvendelse deraf til cancerbehandling - Google Patents
Mitokondriel aldehyddehydrogenase 2 (aldh2)-bindende polycykliske amider og anvendelse deraf til cancerbehandling Download PDFInfo
- Publication number
- DK3107899T3 DK3107899T3 DK15711336.6T DK15711336T DK3107899T3 DK 3107899 T3 DK3107899 T3 DK 3107899T3 DK 15711336 T DK15711336 T DK 15711336T DK 3107899 T3 DK3107899 T3 DK 3107899T3
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- DK
- Denmark
- Prior art keywords
- mitocondrial
- aldh2
- cancer treatment
- binding
- amides
- Prior art date
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- 108010020056 Hydrogenase Proteins 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 150000001299 aldehydes Chemical class 0.000 title 1
- 150000001408 amides Chemical class 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
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- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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US201461941909P | 2014-02-19 | 2014-02-19 | |
PCT/US2015/016703 WO2015127137A1 (en) | 2014-02-19 | 2015-02-19 | Mitochondrial aldehyde dehydrogenase 2 (aldh2) binding polycyclic amides and their use for the treatment of cancer |
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DK3107899T3 true DK3107899T3 (da) | 2020-11-16 |
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EP (1) | EP3107899B1 (da) |
JP (1) | JP6615769B2 (da) |
KR (1) | KR102319882B1 (da) |
CN (1) | CN106458910B (da) |
CA (1) | CA2940269C (da) |
DK (1) | DK3107899T3 (da) |
ES (1) | ES2833157T3 (da) |
HU (1) | HUE051255T2 (da) |
PL (1) | PL3107899T3 (da) |
PT (1) | PT3107899T (da) |
WO (1) | WO2015127137A1 (da) |
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JP7165357B2 (ja) * | 2016-07-26 | 2022-11-04 | コーネル ユニヴァーシティー | アルデヒドデヒドロゲナーゼ欠損症の治療のための遺伝子治療 |
WO2018204673A1 (en) * | 2017-05-05 | 2018-11-08 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for treating endometriosis and endometriosis associated symptoms |
CN108929263B (zh) * | 2017-05-26 | 2022-07-22 | 中国医学科学院药物研究所 | 芳酰胺类Kv2.1抑制剂及其制备方法、药物组合物和用途 |
US20190083457A1 (en) * | 2017-09-15 | 2019-03-21 | The Borad Of Trustees Of The Leland Stanford Junior University | Mitochondrial aldehyde dehydrogenase-2 modulators for protecting, expanding and increasing the potency of hematopoietic stem cells |
JP2020536970A (ja) * | 2017-10-16 | 2020-12-17 | アミグダラ ニューロサイエンシス インコーポレイテッド | 嗜癖を予防するための組み合わせ療法 |
CN108376559B (zh) * | 2018-02-28 | 2020-10-16 | 复旦大学附属中山医院 | 乙醛脱氢酶2基因型在麻醉剂量计算中的应用 |
AU2019315444A1 (en) * | 2018-07-31 | 2021-02-11 | The Trustees Of Princeton University | Tetrahydroquinolino derivatives for the treatment of metastatic and chemoresistant cancers |
US20230128402A1 (en) * | 2020-01-24 | 2023-04-27 | The Trustees Of Princeton University | Heterocyclic compounds and uses thereof |
KR102460545B1 (ko) | 2020-02-18 | 2022-10-31 | 주식회사 피코엔텍 | 신규한 돌연변이 효모를 함유하는 천식 억제용 조성물 |
WO2022092310A1 (ja) | 2020-11-02 | 2022-05-05 | 株式会社アークメディスン | 化合物、アルデヒドデヒドロゲナーゼ2活性化剤、医薬組成物、並びに治療及び/又は予防薬 |
TW202345820A (zh) * | 2022-04-22 | 2023-12-01 | 日商亞克醫藥股份有限公司 | 化合物、醛去氫酶2活化劑、醫藥組合物、以及治療及/或預防藥 |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW197439B (da) | 1991-04-04 | 1993-01-01 | Ueno Pharmaceutics Applic Res Co Ltd | |
US5283253A (en) | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
AU3140093A (en) | 1991-11-22 | 1993-06-15 | University Of Mississippi, The | Synthesis and optical resolution of the taxol side chain and related compounds |
US5200534A (en) | 1992-03-13 | 1993-04-06 | University Of Florida | Process for the preparation of taxol and 10-deacetyltaxol |
EP0642586A4 (en) | 1992-05-21 | 1995-11-29 | Penn State Res Found | CULTURAL -i (TAXUS) FABRIC AS A SOURCE OF TAXOL, RELATED TAXANS AND OTHER NEW ANTI-TUMOR / ANTI-VIRAL SUBSTANCES (01/20/94). |
US5274137A (en) | 1992-06-23 | 1993-12-28 | Nicolaou K C | Intermediates for preparation of taxols |
US5294637A (en) | 1992-07-01 | 1994-03-15 | Bristol-Myers Squibb Company | Fluoro taxols |
US5202448A (en) | 1992-08-14 | 1993-04-13 | Napro Biotherapeutics, Inc. | Processes of converting taxanes into baccatin III |
CA2100808A1 (en) | 1992-10-01 | 1994-04-02 | Vittorio Farina | Deoxy paclitaxels |
FR2696458B1 (fr) | 1992-10-05 | 1994-11-10 | Rhone Poulenc Rorer Sa | Procédé de préparation de dérivés du taxane. |
FR2696461B1 (fr) | 1992-10-05 | 1994-11-10 | Rhone Poulenc Rorer Sa | Nouveaux dérivés d'analogues du taxol, leur préparation et les compositions qui les contiennent. |
FR2696464B1 (fr) | 1992-10-05 | 1994-11-10 | Rhone Poulenc Rorer Sa | Nouveau procédé d'estérification de la baccatine III et de la désacétyl-10 baccatine III. |
FR2696462B1 (fr) | 1992-10-05 | 1994-11-25 | Rhone Poulenc Rorer Sa | Procédé d'obtention de la désacétyl-10 baccatine III. |
FR2696463B1 (fr) | 1992-10-05 | 1994-11-25 | Rhone Poulenc Rorer Sa | Procédé d'obtention de la désacétyl-10 baccatine III. |
US5279949A (en) | 1992-12-07 | 1994-01-18 | Board Of Trustees Operating Michigan State University | Process for the isolation and purification of taxol and taxanes from Taxus spp |
US5824701A (en) | 1993-10-20 | 1998-10-20 | Enzon, Inc. | Taxane-based prodrugs |
US5415869A (en) | 1993-11-12 | 1995-05-16 | The Research Foundation Of State University Of New York | Taxol formulation |
WO1998008833A1 (en) | 1996-08-26 | 1998-03-05 | Bristol-Myers Squibb Company | Sulfenamide taxane derivatives |
EP0961619A4 (en) | 1996-09-27 | 2001-09-26 | Bristol Myers Squibb Co | HYDROLYSABLE DRUGS FOR THE RELEASE OF ANTI-CANCER DRUGS IN METASTATIC CELLS |
WO1998022451A1 (fr) | 1996-11-19 | 1998-05-28 | Daiichi Pharmaceutical Co., Ltd. | Derives taxol |
US5977386A (en) | 1996-12-24 | 1999-11-02 | Bristol-Myers Squibb Company | 6-thio-substituted paclitaxels |
ATE219363T1 (de) | 1997-06-20 | 2002-07-15 | Baker Norton Pharma | Lösliche prodrugs von paclitaxel |
US7288665B1 (en) | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
JPH1192468A (ja) | 1997-09-17 | 1999-04-06 | Yakult Honsha Co Ltd | 新規なタキサン誘導体 |
WO1999018113A1 (fr) | 1997-10-08 | 1999-04-15 | Bio Research Corporation Of Yokohama | Derives taxoides et leur procede de production |
FR2847253B1 (fr) | 2002-11-19 | 2007-05-18 | Aventis Pharma Sa | Nouveaux derives de pyridazinones a titre de medicaments et compositions pharmaceutiques les renfermant |
CA2548254A1 (en) | 2003-12-09 | 2005-06-23 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for modulating mitochondrial aldehyde dehydrogenase-2 |
CN101111479A (zh) * | 2004-12-16 | 2008-01-23 | 沃泰克斯药物股份有限公司 | 可用作激酶抑制剂的吡啶酮 |
US8101770B2 (en) | 2004-12-16 | 2012-01-24 | Vertex Pharmaceuticals Incorporated | Pyridones useful as inhibitors of kinases |
WO2008112164A2 (en) * | 2007-03-08 | 2008-09-18 | The Board Of Trustees Of The Leland Stanford Junior University | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof |
KR20110082180A (ko) * | 2008-10-28 | 2011-07-18 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | 알데히드 탈수소효소의 조절자 및 그것의 사용방법 |
CN102614198B (zh) * | 2012-03-05 | 2014-05-14 | 浙江工业大学 | (4-取代苯甲酰)氟苯水杨酰胺类化合物在制备抗肺癌药物中的应用 |
CN102600182B (zh) * | 2012-03-05 | 2013-09-11 | 浙江工业大学 | 苯乙酰氟苯水杨酰胺类化合物在制备抗肺癌药物中的应用 |
JP6410790B2 (ja) * | 2013-03-14 | 2018-10-24 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | ミトコンドリアアルデヒドデヒドロゲナーゼ−2調節因子およびその使用方法 |
CN103880700B (zh) * | 2014-03-14 | 2016-05-18 | 浙江工业大学 | O-肉桂酰-氟苯水杨酰胺类化合物及其在制备抗宫颈癌药物中的应用 |
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- 2015-02-19 JP JP2016553529A patent/JP6615769B2/ja active Active
- 2015-02-19 KR KR1020167025484A patent/KR102319882B1/ko active IP Right Grant
- 2015-02-19 US US15/120,476 patent/US9879036B2/en active Active
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- 2015-02-19 PL PL15711336T patent/PL3107899T3/pl unknown
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PL3107899T3 (pl) | 2021-01-25 |
US20170057982A1 (en) | 2017-03-02 |
ES2833157T3 (es) | 2021-06-14 |
US9879036B2 (en) | 2018-01-30 |
CN106458910B (zh) | 2020-11-06 |
EP3107899A1 (en) | 2016-12-28 |
CA2940269A1 (en) | 2015-08-27 |
WO2015127137A1 (en) | 2015-08-27 |
EP3107899B1 (en) | 2020-08-12 |
JP6615769B2 (ja) | 2019-12-04 |
KR102319882B1 (ko) | 2021-11-03 |
CN106458910A (zh) | 2017-02-22 |
HUE051255T2 (hu) | 2021-03-01 |
JP2017507147A (ja) | 2017-03-16 |
PT3107899T (pt) | 2020-11-16 |
CA2940269C (en) | 2022-08-16 |
KR20180135129A (ko) | 2018-12-20 |
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